2-[2-(2-氨基乙胺基)乙氧基]乙醇 | 137020-09-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-[2-(2-氨基乙胺基)乙氧基]乙醇
• 英文名称: 2-(2-(2-aminoethylamino)ethoxy)ethanol
• 英文别名: N-[2-(2-Hydroxyethoxy)ethyl]ethylenediamine；2-[2-(2-Aminoethylamino)ethoxy]ethanol
• CAS: 137020-09-8
• 化学式: C₆H₁₆N₂O₂
• 分子量: 148.205
• InChiKey: WVMWULRIHKUMRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  67.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[2-(2-氨基乙胺基)乙氧基]乙醇 在 水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 5.75h， 生成 tert-butyl N-(2-aminoethyl)-N-[2-(2-hydroxyethoxy)ethyl]carbamate
  参考文献：
  名称：

  [EN] NON-LINEAR SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF
  [FR] LIEURS AUTO-IMMOLABLES NON LINÉAIRES ET CONJUGUÉS DE CEUX-CI

  摘要：

  本发明涉及连接子-药物化合物（LDs）和抗体-药物偶联物（ADCs），包括一个非线性自消除连接子，该连接子在适当条件下可被裂解或转化，并减少了抗体-药物偶联物的疏水性。

  公开号：

  WO2018069375A1
• 作为产物：
  描述：

  2-氯乙氧基乙醇 、 乙二胺 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以63%的产率得到2-[2-(2-氨基乙胺基)乙氧基]乙醇
  参考文献：
  名称：

  [EN] NON-LINEAR SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF
  [FR] LIEURS AUTO-IMMOLABLES NON LINÉAIRES ET CONJUGUÉS DE CEUX-CI

  摘要：

  本发明涉及连接子-药物化合物（LDs）和抗体-药物偶联物（ADCs），包括一个非线性自消除连接子，该连接子在适当条件下可被裂解或转化，并减少了抗体-药物偶联物的疏水性。

  公开号：

  WO2018069375A1

文献信息

• Compositions and method comprising heterocyclic compounds containing two
  申请人：——

  公开号：US05030629A1

  公开（公告）日：1991-07-09

  A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I: ##STR1## wherein R is a saturated or unsaturated, straight or branched, cyclic or acyclic hydrocarbon group with from 1 to 19 carbon atoms, alkoxyalkyl, haloalkyl, specifically trifluoromethyl, alkoxy, amino, alkylamino and acylamino; R' and R" are hydrogen, alkyl, trifluoromethyl, alkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, carboxy, carbalkoxy, hydroxyalkyl or lower alkyl ester thereof; X is O or NR.sub.1 wherein R.sub.1 is hydrogen, alkyl, alkenyl, alkoxyalkyl, carbalkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, hydroxyalkyl or hydroxyalkyloxyalkyl and lower alkyl ester thereof; and n is 2 or 3 are disclosed.

  一种用于增强人类和动物皮肤和黏膜对经皮设备或制剂中局部或全身使用的局部应用生理活性药物的吸收的方法和组合物，包括治疗有效量的药用活性剂和公式I的非毒性、有效量的渗透增强剂：##STR1## 其中R是具有1至19个碳原子的饱和或不饱和、直链或支链、环状或非环状的烃基，烷氧基烷基，卤代烷基，特别是三氟甲基，烷氧基，氨基，烷基氨基和酰氨基；R'和R"是氢，烷基，三氟甲基，烷氧基烷基，氨基烷基，烷基和酰氨基烷基，羧基，羧酸烷氧基，羟基烷基或其较低烷基酯；X是O或NR.sub.1，其中R.sub.1是氢，烷基，烯烃基，烷氧基烷基，羧酸烷氧基烷基，氨基烷基，烷基和酰氨基烷基，羟基烷基或羟基烷氧基烷基及其较低烷基酯；n为2或3。
• Aqueous compositions containing overbased materials
  申请人：The Lubrizol Corporation

  公开号：EP0084966A2

  公开（公告）日：1983-08-03

  An aqueous composition comprising: (A) water; (B) an overbased material dispersed with component (A), said overbased material being selected from the group consisting of (B)(I) a Newtonian overbased material or (B)(II) a non-Newtonian colloidal disperse system comprising (1) solid metal-containing colloidal particles predispersed in (2) a disperse medium of at least one inert organic liquid and (3) as an essential third component at least one member selected from the class consisting of organic compounds which are substantially soluble in said disperse medium, the molecules of said organic compound being characterized by polar substituents and hydrophobic portions; and an effective amount of at least one additional component to disperse component (B) with component (A), said additional component being selected from the group consisting of (C) at least one nitrogen-containing, phosphorus-free carboxylic solubilizer made by the reaction of (C)(I) at !east one carboxylic acid acylating agent having at least one hydrocarbon-based substituent of about 12 to about 500 carbon atoms with (C)(II) at least one (a) N-(hydroxyl-substituted hydrocarbyl) amine, (b) hydroxyl-substituted poly(hydrocar- byloxy) analog of said amine or (c) mixture of (a) and (b), (D) at least one surfactant, or (E) mixture of (C) and (D). The foregoing aqueous compositions are optionally provided in combination with (F) a functional additive and/or (G) a dispersion enhancer selected from the group consisting of polyhydroxy compounds and partial ethers of polyhydroxy compounds. A method for cutting hard materials such as quartz, silicon and the like utilizing the foregoing compositions, as well as abrasive slurries for said cutting method and for conventional lapping applications and for metal working or polishing applications is provided.

  一种水性组合物，包括(A) 水；(B) 与组分 (A) 一起分散的过基材料，所述过基材料选自以下组别：(B)(I) 牛顿过基材料或 (B)(II) 非牛顿胶体分散系统，包括 (1) 预先分散在 (2) 至少一种惰性有机液体的分散介质中的含金属固体胶体颗粒；(3) 作为重要的第三组分，至少一种选自有机化合物类别的成员，这些有机化合物基本上可溶于所述分散介质、所述有机化合物的分子具有极性取代基和疏水部分；至少一种有效量的附加组分，用于将组分（B）与组分（A）分散，所述附加组分选自由以下组别 (C) 至少一种含氮无磷羧基增溶剂，由(C)(I)与......反应制得！(C)(II)至少一种(a)N-(羟基取代的烃基)胺，(b)所述胺的羟基取代的聚(烃基氧基)类似物，或(c)(a)和(b)的混合物，(D)至少一种表面活性剂，或(E)(C)和(D)的混合物。上述水性组合物可选择与(F)功能添加剂和/或(G)从多羟基化合物和多羟基化合物部分醚组成的组中选出的分散促进剂结合使用。本发明提供了一种利用上述组合物切割石英、硅等硬质材料的方法，以及用于上述切割方法、传统研磨应用和金属加工或抛光应用的研磨浆料。
• Water-in-oil emulsion fertilizer compositions
  申请人：THE LUBRIZOL CORPORATION

  公开号：EP0711740A1

  公开（公告）日：1996-05-15

  A non-explosive water in oil emulsion fertilizer composition comprising: a discontinuous aqueous phase comprising at least one fertilizer component; a continuous oil phase; an emulsifier comprising the reaction product of at least one succinic acylating agent and at least one co-reactant selected from the group consisting of: primary alkanol amines, secondary alkanol amines, tertiary alkanol amines, primary amines, secondary amines, tertiary amines, poly-amines, alcohols, polyols, and phenols is disclosed. The ferilizer compositions provide for delayed release of the fertilizer components.

  一种非爆炸性油包水乳剂肥料组合物，包括：不连续的水相，其中包含至少一种肥料成分；连续的油相；乳化剂，其中包含至少一种琥珀酰化剂和至少一种共反应物的反应产物，共反应物选自以下组别：伯烷醇胺、仲烷醇胺、叔烷醇胺、伯胺、仲胺、叔胺、多胺、醇、多元醇和酚：本发明公开了一种乳化剂，该乳化剂由至少一种琥珀酰化剂和至少一种选自以下组别的共反应剂的反应产物组成：伯烷醇胺、仲烷醇胺、叔烷醇胺、伯胺、仲胺、叔胺、多胺、醇、多元醇和酚。铁肥组合物可延迟释放肥料成分。
• Polyethoxylated alcohol-based phosphonates for metal working lubricants
  申请人：The Lubrizol Corporation

  公开号：EP0922753A2

  公开（公告）日：1999-06-16

  Disclosed is a metal working composition comprising a major amount of water and a minor amount of an additive comprising (A) at least one carboxylic ester characterized by the formula wherein R0 is a hydrogen, methyl, ethyl, -CH2COOR2 or -CH2CO(OCHR5CH2)nOR6, R1 is hydrogen, methyl or ethyl, R2 is an alkyl group containing from 1 to 12 carbon atoms; R3 is hydrogen or -CO(OCHR5CH2)nOR6, R5 is hydrogen or a methyl group, R6 is a aliphatic group containing from 4 to 30 carbon atoms or a phenyl or aliphatic substituted phenyl group wherein the aliphatic substituent contains from 1 to 8 carbon atoms, R4 is -COOR2, or -CO(OCHR5CH2)nOR6 and n is a integer of from 1 to 30; with the proviso that when R0 does not equal hydrogen, methyl or ethyl that R1 and R3 are hydrogen and (B) at least one rust inhibitor comprising (1) an amine acid salt or amide; (2) a nitrogen-containing, phosphorus-free carboxylic composition; (3) an amine; or (4) an alkoxylated amine.

  公开了一种金属加工组合物，它由大量的水和少量的添加剂组成，添加剂包括 (A) 至少一种羧酸酯，其特征为式 其中 R0 是氢、甲基、乙基、-CH2COOR2 或-CH2CO(OCHR5CH2)nOR6，R1 是氢、甲基或乙基，R2 是含有 1 至 12 个碳原子的烷基；R3 是氢或-CO(OCHR5CH2)nOR6，R5 是氢或甲基，R6 是含有 4 至 30 个碳原子的脂肪族基团或苯基或脂肪族取代的苯基，其中脂肪族取代基含有 1 至 8 个碳原子，R4 是-COOR2，或-CO(OCHR5CH2)nOR6，n 是 1 至 30 的整数；但当 R0 不等于氢、甲基或乙基时，R1 和 R3 是氢，R4 是-COOR2，或-CO(OCHR5CH2)nOR6，n 是 1 至 30 的整数。 (B) 至少一种防锈剂，包括 (1) 氨基酸盐或酰胺； (2) 含氮无磷羧基组合物 (3) 一种胺；或 (4) 烷氧基化胺。
• Lubricating compositions
  申请人：The Lubrizol Corporation

  公开号：EP0972819A1

  公开（公告）日：2000-01-19

  Disclosed is a lubricating composition having a major amount of an oil of lubrication viscosity and a minor amount of (A) a nitrogen containing dispersant with a total base number of from 20 to 160 on an oil-free basis wherein the improvement comprises adding to said dispersant; the dispersant comprising a Mannich reaction product and/or a reaction product of a hydrocarbyl-substituted succinic acylating agent with ammonia or an amine; (B) a sludge preventing/seal protecting additive of at least one aldehyde or epoxide or mixtures thereof.

  本发明公开了一种润滑组合物，其主要成分是润滑粘度油，次要成分是 (A) 含氮分散剂，其总碱基数在无油基础上为 20 至 160，其中的改进包括向所述分散剂中添加；该分散剂包括曼尼希反应产物和/或烃基取代的琥珀酰化剂与氨或胺的反应产物； (B) 由至少一种醛或环氧化物或其混合物组成的污泥防止/密封保护添加剂。