1-(2-thioxothiazolidin-3-yl)butan-1-one | 75594-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(2-thioxothiazolidin-3-yl)butan-1-one
• 英文别名: 3-butyryl thiazolidine-2-thione；N-butanoylthiazolidine-2-thione；1-(2-Sulfanylidene-1,3-thiazolidin-3-yl)butan-1-one
• CAS: 75594-82-0
• 化学式: C₇H₁₁NOS₂
• 分子量: 189.302
• InChiKey: UMVOTQRGCXSFIH-UHFFFAOYSA-N

物化性质

• 沸点：
  279.2±23.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-thioxothiazolidin-3-yl)butan-1-one 、 dibutyl(oxolan-2-yloxy)borane 生成 3-[(E)-1-dibutylboranyloxybut-1-enyl]-1,3-thiazolidine-2-thione
  参考文献：
  名称：

  HSIAO, CHI-NUNG;ASHBURN, S. P.;MILLER, M. J., TETRAHEDRON LETT., 1985, 26, N 40, 4855-4858

  摘要：

  DOI：
• 作为产物：
  描述：

  2-巯基噻唑啉 、 丁酰氯 在 吡啶 、 二氯甲烷 作用下， 生成 1-(2-thioxothiazolidin-3-yl)butan-1-one
  参考文献：
  名称：

  手性酰基噻唑烷硫酮衍生的烯醇硼酸酯的对映选择性羟醛反应

  摘要：

  酰基噻唑烷硫酮在烯醇硼化学中作为手性助剂的相容性已通过对映选择性的醛醇缩合得到证实。醛醇缩合产物可直接获得手性β-内酰胺。

  DOI：

  10.1016/s0040-4039(00)94969-4

文献信息

• NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES
  申请人：Hu Lihong

  公开号：US20100113498A1

  公开（公告）日：2010-05-06

  The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.

  该发明提供了以下式1所表示的长春碱衍生物或其生理上可接受的盐，它们的制备、用途以及包含所述衍生物的药物组合物。所述长春碱衍生物对肿瘤细胞系表现出抑制活性，可用作治疗恶性肿瘤的药物。
• The application of highly stereoselective aldol condensations to the synthesis of β-lactam antibiotics.
  作者：Mankil Jung、Marvin J. Miller

  DOI：10.1016/s0040-4039(00)98490-9

  日期：1985.1

  Stereoselective aldol condensations of fully protected glycine and 3-butyryl thiazolidine-2-thiones with achiral aldehydes afforded β-hydroxyesters suitable for elaboration to key intermediates for the synthesis of β-lactam antibiotics.

  完全保护的甘氨酸和3-丁酰基噻唑烷-2-硫酮与非手性醛的立体选择性醛醇缩合得到适合于合成β-内酰胺抗生素关键中间体的β-羟基酯。
• Ni(II) Tol-BINAP-Catalyzed Enantioselective Orthoester Alkylations of <i>N</i>-Acylthiazolidinethiones
  作者：David A. Evans、Regan J. Thomson

  DOI：10.1021/ja053386s

  日期：2005.8.1

  The development of a Ni(II) (S)-Tol-BINAP-catalyzed enantioselective alkylation of N-acylthiazolidinethiones with trimethyl orthoformate is described. The reaction is general with respect to the thiazolidinethione, providing the desired adducts in good to excellent yield and with high levels of enantioselectivity (11 examples, 51-92% yield, 90-99% ee). The products are readily converted into a variety of synthetically useful derivatives in a straightforward manner.
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.
• US8168647B2
  申请人：——

  公开号：US8168647B2

  公开（公告）日：2012-05-01