N,N'-bis-(benzoylamino-methyl)-urea | 61650-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis-(benzoylamino-methyl)-urea
• 英文别名: N,N'-Bis-(benzoylamino-methyl)-harnstoff；N.N'-Bis-(benzaminomethyl)-harnstoff；Dihippenylharnstoff；N,N'-Bis(benzoylaminomethyl)harnstoff；N,N'-[Carbonylbis(azanediylmethylene)]dibenzamide；N-[(benzamidomethylcarbamoylamino)methyl]benzamide
• CAS: 61650-25-7
• 化学式: C₁₇H₁₈N₄O₃
• 分子量: 326.355
• InChiKey: QVQZTWZMNKRWEC-UHFFFAOYSA-N

物化性质

• 熔点：
  246-246.5 °C
• 沸点：
  738.6±45.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  99.3
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [(2-苯甲酰氨基乙酰基)氨基] 2,2-二甲基丙酸酯 以 水 为溶剂， 生成 N,N'-bis-(benzoylamino-methyl)-urea
  参考文献：
  名称：

  测定肽中羧基末端残基的方法的化学方法。

  摘要：

  DOI：

  10.1021/jo00430a018

文献信息

• Curtius, Journal fur praktische Chemie (Leipzig 1954), 1913, vol. <2> 87, p. 527
  作者：Curtius

  DOI：——

  日期：——
• Curtius, Journal fur praktische Chemie (Leipzig 1954), 1895, vol. <2> 52, p. 270
  作者：Curtius

  DOI：——

  日期：——
• Effect of acute elevation of IGF-I on circulating GH, TSH, insulin, IGF-II and IGFBP-3 levels in non-endocrine short stature (NESS)
  作者：Kunihiko Hanew、A. Tanaka

  DOI：10.1007/bf03343801

  日期：2001.1

  It is not clear whether acute and slight elevation of serum IGF-I, which does not affect blood glucose levels, modulates circulating GH levels. To clarify this, small doses of recombinant human IGF-I (rhIGF-I, 5 microg/kg, i.v.) were administered as a bolus to 10 children with non-endocrine short stature (NESS) (5 males and 5 females, 11.2+/-0.7 yr old) after an overnight fast. Physiological saline was administered intravenously to sex- and age-matched NESS controls (5 males and 5 females, 10.9+/-0.7 yr old). The changes of serum GH, TSH, PRL, IGF-I, IGF-II, IGFBP-3, T4, T3 and plasma glucose levels after the administration were compared to those of the control subjects. Serum IGF-I levels increased significantly from 15 to 150 min after injection compared to those in the control group. The peak value was observed at 15 min (delta increment, 74.6+/-11.8 microg/l). At 15 min after the injection, serum insulin was suppressed significantly (p<0.05), although plasma glucose levels were not modified significantly. Serum TSH showed a significant decrease by rhIGF-I at 15 min and 60 min, whereas serum T4 and T3 levels were not modified. Serum GH was also significantly suppressed at 60 min (p<0.02) and showed a rebound increase at 120 min (p<0.05). Serum IGFBP-3 levels after rhIGF-I were higher than controls at 90 min and 150 min. No significant changes of serum PRL, IGF-II, (IGF-I plus IGF-II)/IGFBP-3 ratios were observed after the IGF-I injection compared to controls. These results indicate that circulating IGF-I is a physiological regulator of GH secretion in normal children, since the changes of IGF-I after the small doses of rhlGF-I administration were within physiological ranges and did not affect plasma glucose levels.
• The Rearrangement of Aminoacetohydroxamic Acid
  作者：Charles D. Hurd、Joyce Wang Fan

  DOI：10.1021/ja01145a041

  日期：1951.1
• The chemistry of a method for the determination of carboxyl-terminal residues in peptides
  作者：Marvin J. Miller、F. Eugene DeBons、G. Marc Loudon

  DOI：10.1021/jo00430a018

  日期：1977.5