7-chloro-2-(chloromethyl)imidazo[1,2-a]pyridine | 124168-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 7-chloro-2-(chloromethyl)imidazo[1,2-a]pyridine
• CAS: 124168-59-8
• 化学式: C₈H₆Cl₂N₂
• 分子量: 201.055
• InChiKey: UCEJKAASHOWNTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Heterocyclic oxophtalazinyl acetic acids
  申请人：PFIZER INC.

  公开号：EP0322153A2

  公开（公告）日：1989-06-28

  A heterocyclic oxophthalazinyl acetic acid having aldose reductase inhibitory activity of the formula wherein X is oxygen or sulfur, Z is a covalent bond, O, S, NH or CH₂ or CHR₅Z is vinylene; R₁ is hydroxy, or a prodrug group; R₂ is a heterocyclic group, R₃ and R₄ are hydrogen or the same or a different substituent, and R₅ is hydrogen, methyl or trifluoromethyl. The pharmaceutically acceptable acid addition salts of the above compounds wherein R₁ is di(C₁-C₄)alkylamino or (C₁-C₄)alkoxy substituted by N-morpholino or di(C₁-C₄)alkylamino and the pharmaceutically active base addition salts of the above compounds wherein R₁ is hydroxy are also aldose reductase inhibitors.

  一种具有醛糖还原酶抑制活性的杂环噁酞嗪基乙酸，其式为 其中 X 是氧或硫，Z 是共价键、O、S、NH 或 CH₂ 或 CHR₅Z 是乙烯基；R₁ 是羟基或原药基团；R₂ 是杂环基团，R₃ 和 R₄ 是氢或相同或不同的取代基，R₅ 是氢、甲基或三氟甲基。R₁ 是二(C₁-C₄)烷基氨基或被 N-吗啉基或二(C₁-C₄)烷基氨基取代的(C₁-C₄)烷氧基的上述化合物的药学上可接受的酸加成盐，以及 R₁ 是羟基的上述化合物的药学上有活性的碱加成盐也是醛糖还原酶抑制剂。
• DIBENZOOXEPIN DERIVATIVE
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2740730B1

  公开（公告）日：2016-11-16
• ANALOGUES OF CILOSTAZOL
  申请人：CONCERT PHARMACEUTICALS INC.

  公开号：US20130131021A1

  公开（公告）日：2013-05-23

  This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
• US8969345B2
  申请人：——

  公开号：US8969345B2

  公开（公告）日：2015-03-03