N'-(4-nitro-benzoyl)-formohydrazonic acid ethyl ester | 103272-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(4-nitro-benzoyl)-formohydrazonic acid ethyl ester
• 英文别名: N'-(4-Nitro-benzoyl)-formohydrazonsaeure-aethylester；ethyl N-(4-nitrobenzoyl)methanehydrazonate
• CAS: 103272-74-8
• 化学式: C₁₀H₁₁N₃O₄
• 分子量: 237.215
• InChiKey: PCMJJALKHURVFD-UHFFFAOYSA-N

物化性质

• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  93.83
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N'-(4-nitro-benzoyl)-formohydrazonic acid ethyl ester 、 邻苯二胺 以 异丙醇 为溶剂， 反应 8.0h， 以75%的产率得到苯并咪唑
  参考文献：
  名称：

  N-Acylethoxymethylene Hydrazones as the Source of a C₁Fragment

  摘要：

  所述化合物被发现是合适的肼或邻苯二胺环闭合的有效试剂。它们与1,3-二甲基巴比妥酸反应时形成了一个新的C=C键。

  DOI：

  10.1055/s-1993-25937
• 作为产物：
  描述：

  4-硝基苯酰肼 、 原甲酸三乙酯 生成 N'-(4-nitro-benzoyl)-formohydrazonic acid ethyl ester
  参考文献：
  名称：

  Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats

  摘要：

  We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A(2) (PLA(2)) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA(2) activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA(2) activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.

  DOI：

  10.1007/bf02883744

文献信息

• Inhibitory effect of metalloporphyrins in conjunction with cholesterol on hepatic phospholipase A2 activityin vivo in rats
  作者：Ramesh Chandra、Manisha Tiwari、Ritu Aneja、Sujata K. Dass、Archana Sharma

  DOI：10.1007/bf02883744

  日期：2000.7

  We investigated the effect of cholesterol and the metalloporphyrins cobalt mesoporphyrin (CoMP) and chromium protoporphyrin (CrPP) on phospholipase A(2) (PLA(2)) activity and the consequent hepatic mitochondrial stability as well as on lipid concentrations. Our studies revealed that on administration of cholesterol, CrPP, CoMP as well as simultaneous adminstration of cholesterol and CrPP, there was an inhibition of PLA(2) activity. These moieties may therefore, be agents for preventing destabilisation of the mitochondrial membrane and the consequent pathological conditions which may arise due to membrane lysis. Our results revealed that cholesterol administration increased phospholipid concentration, albeit by modest amounts. Although the independent administration of metalloporphyrins led only to minor elevations in phospholipid concentration, the simultaneous administration of cholesterol and CrPP generated a steep elevation in the concentration of total phospholipid. Since cholesterol inhibits PLA(2) activity it has the potential of being therapeutic agent for preventing the pathological conditions which may arise due to membrane lysis.
• <i>N</i>-Acylethoxymethylene Hydrazones as the Source of a C₁Fragment
  作者：Marijan Kočevar、Polona Sušin、Slovenko Polanc

  DOI：10.1055/s-1993-25937

  日期：——

  The title compounds were found to be efficient reagents for the ring closure of the appropriate hydrazines or o-phenylenediamine. A new C=C bond was formed on their reaction with 1,3-dimethylbarbituric acid.

  所述化合物被发现是合适的肼或邻苯二胺环闭合的有效试剂。它们与1,3-二甲基巴比妥酸反应时形成了一个新的C=C键。