2-methyl-3H-phenothiazin-3-one | 33209-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2-methyl-3H-phenothiazin-3-one
• 英文别名: 2-Methyl-phenothiazin-3-one；2-methylphenothiazin-3-one
• CAS: 33209-90-4
• 化学式: C₁₃H₉NOS
• 分子量: 227.287
• InChiKey: WCRLZFOXWGIXGP-UHFFFAOYSA-N

物化性质

• 沸点：
  356.7±42.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丁硫醇 、 2-methyl-3H-phenothiazin-3-one 、 2,3-二氯-5,6-二氰基-1,4-苯醌 在 三乙胺 作用下， 以 1,1-二氯乙烷 为溶剂， 生成 4-(n-Butylthio)-2-methyl-3H-phenothiazin-3-one
  参考文献：
  名称：

  Phenothiazone derivatives and analogs

  摘要：

  苯并噻唑衍生物及其类似物、药物组合物和治疗方法已被披露。这些化合物可用作哺乳动物白三烯生物合成的抑制剂。因此，这些化合物是治疗过敏症、哮喘、心血管疾病和炎症的有用治疗剂。

  公开号：

  US04667032A1
• 作为产物：
  描述：

  zinc 2-aminobenzenethiolate 、 甲基苯醌 以 乙醇 为溶剂， 生成 2-methyl-3H-phenothiazin-3-one
  参考文献：
  名称：

  Terdic,M., Justus Liebigs Annalen der Chemie, 1971, vol. 746, p. 200 - 206

  摘要：

  DOI：

文献信息

• Ecofriendly syntheses of phenothiazones and related structures facilitated by laccase – a comparative study
  作者：Mark D. Cannatelli、Arthur J. Ragauskas

  DOI：10.1016/j.tetlet.2016.07.016

  日期：2016.8

  The biocatalytic synthesis of phenothiazones and related compounds has been achieved in an aqueous system under mild conditions facilitated by laccase oxidation. It was found that by coupling 2-aminothiophenol directly with 1,4-quinones, the product yields could be significantly increased compared to generating the 1,4-quinones in situ from the corresponding hydroquinones via laccase oxidation. However

  在漆酶氧化促进的温和条件下，已在水性体系中实现了吩噻硫酮和相关化合物的生物催化合成。发现通过将2-氨基硫酚直接与1，4-醌偶联，与通过漆酶氧化从相应的氢醌原位生成1，4-醌相比，产物产率可以显着提高。然而，漆酶仍然被证明对于通过催化最后的氧化步骤来获得最高的产品收率至关重要。此外，观察到芳族和脂族胺对1，4-萘醌的反应性不同。这项研究为生物重要的一类化合物的合成提供了一种可持续的方法。
• Electrochemical Synthesis of Phenothiazinone as Fluorophore and Its Application in Bioimaging
  作者：Qian Wang、Yue‐Xi Chen、Su‐Hui Ji、Jian‐Min Zhou、Ren‐Hao Li、Yun‐Rui Cai

  DOI：10.1002/chem.202302124

  日期：2023.11.21

  Electrochemical synthesis of phenothiazinone via oxidative cyclocondensation of quinone and 2-aminothiophenol under mild condition is presented, along with its bio-application as fluorophore for lipid droplets imaging in living cells.

  介绍了在温和条件下通过醌和 2-氨基苯硫酚的氧化环缩合作用电化学合成吩噻嗪酮，及其作为活细胞脂滴成像荧光团的生物应用。
• Use of lipoxygenase inhibitors for the preparations of cytoprotective pharmaceutical compostions and process for the preparation of a cytoprotective pharmaceutical composition
  申请人：Merck & Co., Inc.

  公开号：EP0155623A2

  公开（公告）日：1985-09-25

  Lipoxygenase inhibitors are used as cytoprotective active ingredient in producing cytoprotective pharmaceutical compositions. Corresponding cytoprotective pharmaceutical compositions are prepared by incorporating into a pharmaceutical composition a lipoxygenase inhibitor in a cytoprotective active amount. The prepared cytoprotective therapeutic composition may be used to treat or prevent disease states such as erosive gastritis, erosive esophagitis, inflammatory bowel disease, and induced hemorrhagic gastric erosions such as those caused by indomethacin or ethanol. The lipoxygenase inhibitors induce cytoprotection via an unspecified mechanism.

  脂氧合酶抑制剂作为细胞保护活性成分可用于生产细胞保护药物组合物。相应的细胞保护药物组合物是通过在药物组合物中加入具有细胞保护活性量的脂氧合酶抑制剂来制备的。制备的细胞保护治疗组合物可用于治疗或预防疾病状态，如糜烂性胃炎、糜烂性食管炎、炎症性肠病和诱导性出血性胃糜烂，如由吲哚美辛或乙醇引起的胃糜烂。脂氧合酶抑制剂通过不明机制诱导细胞保护。
• Electrochemichromic solutions, processes for preparing and using the same, and devices manufactured with the same
  申请人：DONNELLY CORPORATION

  公开号：EP0531143A2

  公开（公告）日：1993-03-10

  The present invention relates to electrochromic solutions and devices manufactured therefrom. More precisely, the present invention relates to electrochemichromic compounds and processes for preparing the same. The present invention also relates to electrochemichromic solutions of such compounds, and those devices manufactured with the same, that demonstrate superior responsiveness to those solutions known heretofore when an applied potential is introduced thereto. And, these solutions, when contained within electrochemichromic devices, demonstrate ultraviolet stability, thermal stability and cycle stability. The responsiveness observed in terms of solution coloring with respect to the solutions, and devices containing the same, of the present invention is of a greater rapidity, intensity and uniformity than those electrochemichromic solutions of the prior art. Preparation of these solutions involve the novel process of pre-treating at least one of the electrochemichromic compounds with a redox agent prior to placing it in contact with the other electrochemichromic compound. Moreover, the present invention relates to methods of preparing such novel solutions and processes for using these solutions to provide devices that exhibit and benefit from the aforementioned superior characteristics.

  本发明涉及电致变色溶液及其制造的装置。更确切地说，本发明涉及电致变色化合物及其制备工艺。本发明还涉及此类化合物的电致变色溶液，以及用其制造的装置，当引入外加电位时，这些装置的反应能力优于迄今已知的溶液。而且，当这些溶液装入电致变色装置时，会表现出紫外线稳定性、热稳定性和循环稳定性。与现有技术中的电致发光溶液相比，本发明的溶液和含有本发明溶液的装置在溶液着色方面的反应速度更快、强度更大、更均匀。这些溶液的制备涉及一种新工艺，即在将至少一种电致变色化合物与另一种电致变色化合物接触之前，用氧化还原剂对其进行预处理。此外，本发明还涉及制备这种新型溶液的方法，以及使用这些溶液提供显示并受益于上述优异特性的装置的工艺。
• Electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films, and processing for making such solid films and devices
  申请人：DONNELLY CORPORATION

  公开号：EP0612826A1

  公开（公告）日：1994-08-31

  The present invention relates to electrochromic polymeric solid films, manufacturing electrochromic devices using such solid films and processes for making such solid films and devices. The electrochromic polymeric solid films of the present invention exhibit beneficial properties and characteristics, especially when compared to known electrochromic media. The electrochromic polymeric solid films are transformed in situ from a low viscosity electrochromic monomer composition by exposure to electromagnetic radiation, and in so doing minimum shrinkage occurs. The electrochromic polymeric solid films of the present invention also perform well under prolonged coloration, outdoor weathering and all-climate exposure, and provide an inherent safety aspect not known to electrochromic media heretofore.

  本发明涉及电致变色聚合物固体薄膜、使用这种固体薄膜制造电致变色装置以及制造这种固体薄膜和装置的工艺。本发明的电致变色聚合固体薄膜具有良好的性能和特点，特别是与已知的电致变色介质相比。本发明的电致变色聚合固体薄膜是由低粘度电致变色单体组合物通过电磁辐射就地转化而成的，在此过程中会产生最小程度的收缩。本发明的电致变色聚合固体薄膜在长时间着色、户外风化和全天候暴露的情况下也有良好的表现，并具有电致变色介质前所未有的内在安全性。