3,4-dihydro-2,4,6-trimethyl-2H-1,4-oxazine | 128595-25-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,4-dihydro-2,4,6-trimethyl-2H-1,4-oxazine
• 英文别名: 2,4,6-trimethyl-2,3-dihydro-1,4-oxazine
• CAS: 128595-25-5
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: GMKJECGIARQABX-UHFFFAOYSA-N

物化性质

• 沸点：
  160.2±20.0 °C(Predicted)
• 密度：
  0.909±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,1’-(甲基亚氨基)二(2-丙醇) 在 ruthenium trichloride 、 三苯基膦 苄叉丙酮 作用下， 以 various solvent(s) 为溶剂， 以65%的产率得到3,4-dihydro-2,4,6-trimethyl-2H-1,4-oxazine
  参考文献：
  名称：

  Ruthenium-catalyzed synthesis of substituted 2-hydroxymorpholines and substituted morpholines

  摘要：

  The reaction of primary amines with peroxides afforded substituted hydroxymorpholines which were then converted to substituted morpholines via dihydrooxazines as intermediates. The reaction appears to proceed through a ruthenium-catalyzed dehydrogenation-cyclization process.

  DOI：

  10.1016/s0040-4039(00)91563-6

文献信息

• Process for preparing oxazine derivatives
  申请人：Texaco Chemical Company

  公开号：US04910303A1

  公开（公告）日：1990-03-20

  This invention relates to the reaction of N-alkyl-bis-(2-hydroxyalkyl)amines to form oxazine derivatives by a process comprising reacting said amines in the presence of a ruthenium-containing compound and hydrogen acceptor.

  本发明涉及使用含钌化合物和氢受体的方法，通过反应N-烷基双（2-羟基烷基）胺来形成噁唑啉衍生物。
• US4910303A
  申请人：——

  公开号：US4910303A

  公开（公告）日：1990-03-20
• Ruthenium-catalyzed synthesis of substituted 2-hydroxymorpholines and substituted morpholines
  作者：Wei-Yang Su、C.L. LeBas、Albert C. Kopecky、John F. Knifton

  DOI：10.1016/s0040-4039(00)91563-6

  日期：1992.2

  The reaction of primary amines with peroxides afforded substituted hydroxymorpholines which were then converted to substituted morpholines via dihydrooxazines as intermediates. The reaction appears to proceed through a ruthenium-catalyzed dehydrogenation-cyclization process.