5-bromo-1,3-dihydrobenzo[c]thiophene | 150527-38-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 5-bromo-1,3-dihydrobenzo[c]thiophene
• 英文别名: 5-bromo-1,3-dihydro-2-benzothiophene
• CAS: 150527-38-1
• 化学式: C₈H₇BrS
• 分子量: 215.114
• InChiKey: RVXDMJNCFCLOLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-bromo-1,3-dihydrobenzo[c]thiophene 在 oxone 、 sodium hydrogen sulfate 、 碳酸氢钠 作用下， 以 甲醇 、 水 为溶剂， 反应 2.17h， 以65%的产率得到5-溴-1,3-二氢-苯并(c)噻吩2,2-二氧化物
  参考文献：
  名称：

  [EN] SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP
  [FR] MODULATEURS SELECTIFS DES RECEPTEURS OESTROGENIQUES CONTENANT UN GROUPE PHENYLSULFONYLE

  摘要：

  本发明涉及式I的选择性雌激素受体调节剂或其药用酸盐加合物；例如，用于治疗子宫内膜异位症和/或子宫平滑肌瘤。

  公开号：

  WO2004009086A1
• 作为产物：
  描述：

  4-溴-1,2-双(溴甲基)苯 在 Na₂S*9H₂O 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以95.63%的产率得到5-bromo-1,3-dihydrobenzo[c]thiophene
  参考文献：
  名称：

  [EN] P300 INHIBITORS AND USE THEREOF IN MEDICINE
  [FR] INHIBITEURS DE P300 ET LEUR UTILISATION EN MÉDECINE
  [ZH] P300抑制剂及其在医药上的应用

  摘要：

  涉及一种化合物，其具有癌症治疗活性,还涉及这些化合物的制备方法以及包含其的药物组合物。

  公开号：

  WO2022095989A1

文献信息

• 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
  申请人：BAO JIANMING

  公开号：US20170183342A1

  公开（公告）日：2017-06-29

  The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

  本发明涉及6,7-二氢-5H-吡咯[3,4-b]吡啶-5-酮化合物，这些化合物是M4毒蕈碱乙酰胆碱受体的变构调节剂。本发明还涉及在本申请中描述的化合物在潜在治疗或预防神经和精神障碍和疾病中的应用，其中涉及M4毒蕈碱乙酰胆碱受体。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在预防或治疗涉及M4毒蕈碱乙酰胆碱受体的疾病的应用。
• PYRROLO-, PYRAZOLO-, IMIDAZO-PYRIMIDINE AND PYRIDINE COMPOUNDS THAT INHIBIT MNK1 AND MNK2
  申请人：EFFECTOR THERAPEUTICS, INC.

  公开号：US20170121339A1

  公开（公告）日：2017-05-04

  The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , W 1 , R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 6 , R 7 , R 7a , R 7b , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b and R 10 and subscripts “m” and “n” are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

  本发明提供了根据式I合成的化合物、药用可接受的配方以及用途，或者其立体异构体、互变异构体或药用可接受的盐。对于式I化合物A1、A2、A3、A4、A5、A6、A7、W1、R1、R2、R3、R4、R5a、R5b、R6、R7、R7a、R7b、R8、R8a、R8b、R9、R9a、R9b和R10以及下标“m”和“n”的定义如规范中所述。这些创新的式I化合物是Mnk的抑制剂，并在许多治疗应用中发挥作用，包括但不限于治疗炎症和各种癌症。
• Selective estrogen receptor modulators containing a phenylsulfonyl group
  申请人：Dally Dean Robert

  公开号：US20060183736A1

  公开（公告）日：2006-08-17

  The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.

  本发明涉及式I的选择性雌激素受体调节剂或其药物酸盐加合物；例如，用于治疗子宫内膜异位症和/或子宫平滑肌瘤/平滑肌瘤。
• SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP
  申请人：Dally Robert Dean

  公开号：US20080214612A1

  公开（公告）日：2008-09-04

  The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.

  本发明涉及公式I的选择性雌激素受体调节剂或其药物酸盐，例如，用于治疗子宫内膜异位症和/或子宫平滑肌瘤/肌瘤。
• DENDRITIC MOLECULAR INTRACELLULAR TRANSPORTERS AND METHODS OF MAKING AND USING SAME
  申请人：Harth Eva M.

  公开号：US20080221043A1

  公开（公告）日：2008-09-11

  In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  根据本发明的目的，本发明在一个方面涉及包含以下结构的化合物，以及至少一个鸟氨酸残基，其中m为零或正整数。还公开了制备所述化合物的方法。还公开了包括将所述化合物和组合物给予受试者的细胞内递送方法。还公开了包括本发明的一个或多个化合物或组合物的治疗有效量和药学可接受载体的制药组合物。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。