3-(3,5-di-t-butyl-4-hydroxyphenylthio)propionic acid | 61151-54-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,5-di-t-butyl-4-hydroxyphenylthio)propionic acid
• 英文别名: 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanoic acid；3-[(3,5-Di-tert-butyl-4-hydroxyphenyl)sulfanyl]propanoic acid；3-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropanoic acid
• CAS: 61151-54-0
• 化学式: C₁₇H₂₆O₃S
• 分子量: 310.458
• InChiKey: RHQSQPMTWAHLAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-thio]propanoate 、 lithium hydroxide monohydrate 以 甲醇 、 水 为溶剂， 生成 3-(3,5-di-t-butyl-4-hydroxyphenylthio)propionic acid
  参考文献：
  名称：

  Phenolic thioethers, sulfoxides, and disulfides as inhibitors of

  摘要：

  本发明的化合物包括取代酚硫醚、亚砜和二硫化物，它们是5-脂氧合酶的特异性抑制剂，因此在治疗局部和全身炎症、过敏和过敏反应以及其他涉及5-脂氧合酶代谢途径中形成的药物的紊乱方面具有用处。

  公开号：

  US05002967A1

文献信息

• Phenolic thioethers, sulfoxides, and disulfides as inhibitors of
  申请人：G. D. Searle & Co.

  公开号：US05002967A1

  公开（公告）日：1991-03-26

  The compounds of the present invention comprise substituted phenolic thioethers, sulfoxides, and disulfides that are specific inhibitors of 5-lipoxygenase and which, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metablic pathway are involved.

  本发明的化合物包括取代酚硫醚、亚砜和二硫化物，它们是5-脂氧合酶的特异性抑制剂，因此在治疗局部和全身炎症、过敏和过敏反应以及其他涉及5-脂氧合酶代谢途径中形成的药物的紊乱方面具有用处。
• SYDNONE IMINE DERIVATIVES
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP0903346A1

  公开（公告）日：1999-03-24

  Compounds represented by the following general formula (1) or pharmaceutically acceptable salts thereof: [wherein Z represents -A-X-R1, a heterocycle or cycloalkyl; A represents a methylene group; X represents a sulfur atom; R1 represents a benzoyl group; R2 represents - N(R3)R4 (wherein R3 represents a methyl group; and R4 represents an optionally substituted alkyl group, etc.); or a group represented by the following general formula (2): wherein R5 and R6 represent each a hydrogen atom; and Y represents a group represented by the following general formula (3): (wherein R4 is as defined above)}]. Because of having vasodilative effect, myocardial protective effect, antiplatelet aggregation effect, etc., the compounds represented by the above general formula (1) or pharmaceutically acceptable salts thereof are useful as drugs such as therapeutic medicines for angina pectoris.

  由以下通式（1）代表的化合物或其药学上可接受的盐类： [其中 Z 代表-A-X-R1、杂环或环烷基；A 代表亚甲基；X 代表硫原子；R1 代表苯甲酰基；R2 代表-N(R3)R4(其中 R3 代表甲基；R4 代表任选取代的烷基等)；或下 列通式(2)所代表的基团： 其中 R5 和 R6 各代表一个氢原子；Y 代表由下式通式 (3) 所代表的基团： (其中 R4 如上定义）}]。 由于具有血管扩张作用、心肌保护作用、抗血小板聚集作用等，上述通式（1）所代表的化合物或其药学上可接受的盐类可用作药物，如心绞痛的治疗药物。
• ORGANIC SEMICONDUCTOR COMPOSITION, ORGANIC THIN FILM TRANSISTOR, ELECTRONIC PAPER, AND DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：EP3203540A1

  公开（公告）日：2017-08-09

  The present invention provides an organic semiconductor composition which makes it possible to prepare an organic thin film transistor having excellent insulation reliability while inhibiting the deterioration of mobility, and to provide an organic thin film transistor prepared using the composition. Furthermore, the present invention provides electronic paper and a display device which contain the organic thin film transistor. The organic semiconductor composition according to the present invention contains an organic semiconductor material and at least one kind of migration inhibitor selected from a compound represented by the following Formula (I), a compound represented by the following Formula (II), and a compound represented by the following Formula (III).

  本发明提供了一种有机半导体组合物，该组合物可制备出绝缘可靠性极佳的有机薄膜晶体管，同时可抑制迁移率劣化，本发明还提供了使用该组合物制备的有机薄膜晶体管。此外，本发明还提供了含有该有机薄膜晶体管的电子纸和显示装置。根据本发明的有机半导体组合物含有一种有机半导体材料和至少一种从下式（I）代表的化合物、下式（II）代表的化合物和下式（III）代表的化合物中选出的迁移抑制剂。
• Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
  申请人：G.D. Searle & Co.

  公开号：EP0293900B1

  公开（公告）日：1994-03-16
• US4690995A
  申请人：——

  公开号：US4690995A

  公开（公告）日：1987-09-01