2,4,5-trifluoro-1,1'-biphenyl | 67277-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,5-trifluoro-1,1'-biphenyl
• 英文别名: 2,4,5-trifluorobiphenyl；2,4,5-Trifluorbiphenyl；1,2,4-trifluoro-5-phenylbenzene
• CAS: 67277-35-4
• 化学式: C₁₂H₇F₃
• 分子量: 208.183
• InChiKey: PQVCARJFWNYBJA-UHFFFAOYSA-N

物化性质

• 沸点：
  246.5±35.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4,5-三氟溴苯 、 苯硼酸 在 C₃₆H₃₃N₄O₁₁PPdS₃^(2-)*BF₄^(1-)*3Na⁽¹⁺⁾ 、 四丁基溴化铵 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 2.0h， 以95%的产率得到2,4,5-trifluoro-1,1'-biphenyl
  参考文献：
  名称：

  含嘌呤基NHC和水溶性膦的新型烯丙基钯配合物的合成及其在水中Suzuki-Miyaura偶联中的催化活性

  摘要：

  我们已经合成并充分表征了由混合的观众配体稳定的一些新颖的烯丙基钯配合物，即水溶性3,3'，3''-膦三基三苯磺酸钠（TPPTS）和三种衍生自不同烷基化天然黄嘌呤的羧甲基。为了探索其潜在应用，我们测试了它们在对溴苯乙酮与苯基硼酸的铃木-宫浦偶联反应中的催化活性，苯硼酸被选作标准反应。研究中的复合物中只有一种在水和催化活性方面显示出显着的稳定性。因此，我们进行了催化研究。这些结果与钯烯丙基络合物的银前体的固态结构表征一起在本论文中进行了报道。

  DOI：

  10.1002/aoc.4034

文献信息

• Synthesis of novel allyl palladium complexes bearing purine based NHC and a water soluble phosphine and their catalytic activity in the Suzuki‐Miyaura coupling in water
  作者：Thomas Scattolin、Luciano Canovese、Fabiano Visentin、Stefano Paganelli、Patrizia Canton、Nicola Demitri

  DOI：10.1002/aoc.4034

  日期：2018.2

  fully characterized some novel allyl palladium complexes stabilized by mixed spectator ligands, namely the water soluble sodium 3,3′,3″‐phosphinetriyltribenzenesulfonate, (TPPTS) and three carbenes derived from differently alkylated natural xanthines. In order to explore their potential applications we have tested their catalytic activity in the Suzuki‐Miyaura coupling of para‐bromoacetophenone with phenyl

  我们已经合成并充分表征了由混合的观众配体稳定的一些新颖的烯丙基钯配合物，即水溶性3,3'，3''-膦三基三苯磺酸钠（TPPTS）和三种衍生自不同烷基化天然黄嘌呤的羧甲基。为了探索其潜在应用，我们测试了它们在对溴苯乙酮与苯基硼酸的铃木-宫浦偶联反应中的催化活性，苯硼酸被选作标准反应。研究中的复合物中只有一种在水和催化活性方面显示出显着的稳定性。因此，我们进行了催化研究。这些结果与钯烯丙基络合物的银前体的固态结构表征一起在本论文中进行了报道。
• Functionalized Phosphonium Ionic Liquids: Synthesis and Application
  作者：Daria Arkhipova、Vadim Ermolaev、Vasili Miluykov、Lilia Nigmatullina、Oleg Sinyashin

  DOI：10.1080/10426507.2014.993759

  日期：2015.6.3

  A series of phosphonium salts with sterically hindered cation (Bu3P+)-P-t(CH2COOEt)X- (X = Cl, BF4, N(SO2CF3)(2)) (1) was prepared for the first time. Palladium nanoparticles (PdNPs) stabilized by (1) showed moderate activity as catalyst in Suzuki cross-coupling reaction of bromoarenes and phenylboronic acid.
• A new method for the preparation of microcapsule-supported palladium catalyst for Suzuki coupling reaction
  作者：Ying Liu、Xiujuan Feng、Decai Bao、Kaixiao Li、Ming Bao

  DOI：10.1016/j.molcata.2010.02.029

  日期：2010.5.17

  In this paper, a new method for the preparation of microcapsule-supported palladium catalyst for Suzuki coupling reaction was described. The highly monodispersed cross-linked polystyrene microcapsules containing phosphine ligand were synthesized by the self-assembling of phase separated polymer (SaPSeP) method using diphenyl(4-vinylphenyl)phosphine and divinylbenzene as a monomer and cross-linking agent, respectively, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator within the droplets of oil-in-water (O/W) emulsions, which were prepared by using the Shirasu porous glass (SPG) membrane emulsification technique. The microcapsule-supported palladium catalyst was obtained by treating the microcapsules with a solution of Pd-2(dba)(3) in dichloromethane. This supported palladium catalyst exhibited high catalytic activity for the Suzuki coupling reaction of various aryl bromides and can be reused several times without the loss of activity. (C) 2010 Elsevier B.V. All rights reserved.
• Allen, Kim J.; Bolton, Roger; Williams, Gareth H., Journal of the Chemical Society. Perkin transactions II, 1983, p. 691 - 696
  作者：Allen, Kim J.、Bolton, Roger、Williams, Gareth H.

  DOI：——

  日期：——
• ALLEN, K. J.;BOLTON, R.;WILLIAMS, G. H., J. CHEM. SOC. PERKIN TRANS., 1983, N 5, 691-695
  作者：ALLEN, K. J.、BOLTON, R.、WILLIAMS, G. H.

  DOI：——

  日期：——