3-(3-Chlorophenyl)-1-methyl-1H-pyrrole-2,5-dione | 89733-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-Chlorophenyl)-1-methyl-1H-pyrrole-2,5-dione
• 英文别名: 3-(3-chlorophenyl)-1-methylpyrrole-2,5-dione
• CAS: 89733-44-8
• 化学式: C₁₁H₈ClNO₂
• 分子量: 221.64
• InChiKey: COEGKDWPTUBURI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes
  申请人：Skolnick Phil

  公开号：US20060223875A1

  公开（公告）日：2006-10-05

  The invention provides novel 1-aryl-3-azabicyclo[3.1.0]hexanes that are active for modulating biogenic amine transport, along with compositions and methods for using these compounds to treat central nervous system disorders. Certain 1-aryl-3-azabicyclo[3.1.0]hexanes are provided that have at least one substituent on the aryl ring. In other embodiments 1-aryl-3-azabicyclo[3.1.0]hexanes are provided that have a substitution on the nitrogen at the ‘3’ position. In additional embodiments 1-aryl-3-azabicyclo[3.1.0]hexanes are provided which have one substitution on the aryl ring, as well as a substitution on the nitrogen at the ‘3’ position. The invention also provides novel methods of making aryl- and aza-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, including synthetic methods that form novel intermediate compounds of the invention for producing aryl- and aza-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes.

  本发明提供了新型的1-芳基-3-氮杂双环[3.1.0]己烷，它们对生物胺转运的调节具有活性，以及使用这些化合物治疗中枢神经系统疾病的组合物和方法。提供了某些1-芳基-3-氮杂双环[3.1.0]己烷，其在芳基环上至少有一个取代基。在其他实施例中，提供了在“3”位的氮上有取代基的1-芳基-3-氮杂双环[3.1.0]己烷。在其他实施例中，提供了在芳基环上有一个取代基以及在“3”位的氮上有一个取代基的1-芳基-3-氮杂双环[3.1.0]己烷。本发明还提供了制备芳基和氮取代的1-芳基-3-氮杂双环[3.1.0]己烷的新方法，包括形成本发明的新中间化合物的合成方法，用于生产芳基和氮取代的1-芳基-3-氮杂双环[3.1.0]己烷。
• 3a-(substituted-phenyl)-hexaloctahydro-4,7-alkanoisoindoles
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0100426A1

  公开（公告）日：1984-02-15

  This disclosure describes 3a-(substituted-phenyl)-2,3,3a,4,7,7a-hexahydro[or 3a-(substituted-phenyl)-octahydro]-4,7-alkano-1H-isoindoles which possess activity as anti-depressants and as antistress agents in mammals.

  本公开介绍了 3a-(取代苯基)-2,3,3a,4,7,7a-六氢[或 3a-(取代苯基)-八氢]-4,7-烷基-1H-异吲哚，它们在哺乳动物体内具有抗抑郁剂和抗惊厥剂的活性。
• Heat resistant copolymer composition
  申请人：Sumitomo Dow Limited

  公开号：EP0267574A2

  公开（公告）日：1988-05-18

  A heat resistant copolymer composition is provided by blending two kinds of copolymers one of which is obtaina­ble by polymerizing a maleimide monomer (A), an aromatic vinyl monomer (B), and unsaturated nitrile monomer (C) and optionally at least one other comonomer copolymerizable therewith (D) in a specific monomer ratio in the presence or absence of an elastomeric polymer and which has an intrinsic viscosity of 0.3 to 1.2 dl/g, and another of which is obtainable by copolymerizing the aromatic vinyl monomer (B), the unsaturated nitrile (C) and optionally at least one other comonomer copolymerizable therewith (D) in a specific monomer ratio in the presence or absence of the elastomeric polymer and which has an intrinsic viscosity of 0.3 to 1.5 dl/g.

  通过混合两种共聚物提供了一种耐热共聚物组合物，其中一种共聚物可通过在有或没有弹性聚合物的情况下，以特定的单体比例聚合马来酰亚胺单体（A）、芳香乙烯基单体（B）和不饱和腈单体（C）以及可与之共聚的至少一种其他共聚单体（D）而获得，其固有粘度为 0.3至1.2分升/克，另一种是在有或没有弹性聚合物的情况下，将芳香乙烯基单体(B)、不饱和腈(C)和至少一种可与之共聚的共聚单体(D)按特定的单体比例共聚而得，其固有粘度为0.3至1.5分升/克。
• US4529736A
  申请人：——

  公开号：US4529736A

  公开（公告）日：1985-07-16