5-carboxymethyl-isophthalic acid | 4435-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-carboxymethyl-isophthalic acid
• 英文别名: 5-Carboxymethyl-isophthalsaeure；3.5-Dicarboxy-phenylessigsaeure；5-(Carboxymethyl)benzene-1,3-dicarboxylic acid
• CAS: 4435-98-7
• 化学式: C₁₀H₈O₆
• 分子量: 224.17
• InChiKey: MMJJGOLCUOXTHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,3,5-三乙基苯 在 铬酸 作用下， 生成 5-carboxymethyl-isophthalic acid
  参考文献：
  名称：

  Friedel; Balsohn, Bulletin de la Societe Chimique de France, 1880, vol. <2> 34, p. 635

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2020252396A1

  公开（公告）日：2020-12-17

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral RSV F protein (e.g., Presatovir, MDT 637, JNJ 179, or an analog thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., RSV infections).

  用于治疗病毒感染的组合物和方法包括含有病毒RSV F蛋白抑制剂（例如Presatovir、MDT 637、JNJ 179或其类似物）的共轭物，连接到一个Fc单体、一个Fc结构域和Fc结合肽、一种白蛋白蛋白质或白蛋白结合肽。特别是，这些共轭物可以用于治疗病毒感染（例如RSV感染）。
• DITHIOAMINE REDUCING AGENTS
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20130211055A1

  公开（公告）日：2013-08-15

  Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins.

  本发明提供了可用于还原二硫键的二硫胺还原剂。本发明的还原剂可用于还原蛋白质中的二硫键，或者预防蛋白质和其他生物分子中的二硫键形成。该发明的还原剂适用于多种生物应用，特别是作为研究和合成试剂。本发明提供了可通过酶或化学方法选择性激活的S-酰化二硫胺还原剂。本发明还提供了硫代氨基还原剂的二硫环前体。本发明提供了固定在表面上的二硫胺还原剂、S-酰化二硫胺和二硫环，包括但不限于玻璃、石英、微粒、纳米粒子和树脂等。
• SUBSTITUTED PYRAZINE DITHIOL REDUCING AGENTS
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20150376591A1

  公开（公告）日：2015-12-31

  Substituted dithiol pyrazine compounds useful as reducing agents in biologically relevant media having formula: where variables are defined herein and corresponding oxidized pyrazine dithianes. Reducing agents useful to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins, and other biological molecules. Reducing agents useful to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. S-acylated dithiol pyrazine compounds, where R 3 is an acyl group, are selectively activated as reducing agents by removal of the S-acyl groups enzymatically or chemically. Dithiol pyrazine reducing agents and corresponding S-acylated dithiol pyrazines, immobilized on surfaces or conjugated to other chemical species, are provided.

  具有以下公式的可用作生物相关介质中还原剂的取代二硫代吡嗪化合物： 其中变量在此定义，对应的氧化的吡嗪二硫代环。 还原剂可用于还原二硫键，特别是在蛋白质中，或者防止二硫键的形成，特别是在蛋白质和其他生物分子中。还原剂可用于调节与生物活性相关的巯基团的蛋白质功能。还原剂可用于各种生物应用，特别是作为研究和合成试剂。S-酰化的二硫代吡嗪化合物，其中R3是酰基，通过酶或化学方法去除S-酰基团而被选择性激活为还原剂。提供了固定在表面上或与其他化学物种结合的二硫代吡嗪还原剂和相应的S-酰化的二硫代吡嗪。
• Dithioamine Reducing Agents
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20190153025A1

  公开（公告）日：2019-05-23

  Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins.
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：Cidara Therapeutics, Inc.

  公开号：US20210220478A1

  公开（公告）日：2021-07-22

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).