2-[4-[3-(4,5-二氯-2-甲基苯基)-4,5-二氢吡唑-1-基]苯基]磺酰基乙基乙酸酯 | 35441-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[4-[3-(4,5-二氯-2-甲基苯基)-4,5-二氢吡唑-1-基]苯基]磺酰基乙基乙酸酯
• 英文名称: 2-((4-(3-(4,5-Dichloro-2-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl)phenyl)sulphonyl)ethyl acetate
• 英文别名: 2-[4-[5-(4,5-dichloro-2-methylphenyl)-3,4-dihydropyrazol-2-yl]phenyl]sulfonylethyl acetate
• CAS: 35441-14-6
• 化学式: C₂₀H₂₀Cl₂N₂O₄S
• 分子量: 455.4
• InChiKey: BPENLBNVXIQZEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHODS OF TREATING MILD BRAIN INJURY
  申请人：Oxeia Biopharmaceuticals Inc.

  公开号：EP3182992A1

  公开（公告）日：2017-06-28
• METHODS OF TREATING TRAUMATIC BRAIN INJURY
  申请人：Oxeia Biopharmaceuticals Inc.

  公开号：EP3197482A1

  公开（公告）日：2017-08-02
• METHODS OF TREATING COGNITIVE IMPAIRMENTS OR DYSFUNCTION
  申请人：Oxeia Biopharmaceuticals, Inc.

  公开号：EP3268021A1

  公开（公告）日：2018-01-17
• METHODS OF TREATING NEURODEGENERATIVE CONDITIONS
  申请人：Oxeia Biopharmaceuticals, Inc.

  公开号：US20170121385A1

  公开（公告）日：2017-05-04

  The present disclosure provides methods for treating a neurodegenerative condition or situation in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising ghrelin or a ghrelin variant.
• [EN] METHODS OF TREATING TRAUMATIC BRAIN INJURY<br/>[FR] PROCÉDÉS DE TRAITEMENT DE LÉSION CÉRÉBRALE TRAUMATIQUE
  申请人：OXEIA BIOPHARMACEUTICALS INC

  公开号：WO2016048488A1

  公开（公告）日：2016-03-31

  The present disclosure provides methods for treating traumatic brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant. This invention provides for methods for treating a severe or moderate traumatic brain injury in a patient wherein said method comprises administering to the subject suffering from said severe or moderate traumatic brain injury a therapeutic effective amount of ghrelin or a ghrelin variant or a composition comprising ghrelin or a ghrelin variant so as to treat said severe or moderate traumatic brain injury.