2-[[(10S,13S)-13-甲基-3,17-二氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-10-基]甲氧基]乙酸 | 79524-41-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 2-[[(10S,13S)-13-甲基-3,17-二氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-10-基]甲氧基]乙酸
• 英文名称: 19-(Carboxymethoxyl)-4-androstene-3,17-dione
• 英文别名: 3,17-dioxo-4-androsten-19-yl carboxymethyl ether；19-O-Carboxymethoxyandrostenedione；2-[[(8R,9S,10S,13S,14S)-13-methyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-10-yl]methoxy]acetic acid
• CAS: 79524-41-7
• 化学式: C₂₁H₂₈O₅
• 分子量: 360.45
• InChiKey: KYEKTOOAXOBUGS-YRJWVXGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  对羟基苯乙胺 、 2-[[(10S,13S)-13-甲基-3,17-二氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-10-基]甲氧基]乙酸 在 sodium hydroxide 、 氯甲酸乙酯 、 三乙胺 作用下， 生成 19-amidocarboxymethoxyl>-4-androstene-3,17-dione
  参考文献：
  名称：

  A chemical approach to solving bridging phenomena in steroid radioimmunoassays

  摘要：

  Steroid radioimmunoassays (RIA) employ antibodies raised against a carrier protein-steroid conjugate. Individual antibodies may recognize the steroid, the protein or the chemical bridge used to join them together. Use of the same bridge in the tracer results in higher affinity binding of the tracer than the native ligand which in turn results in a loss of sensitivity and precision. We have greatly reduced bridge-binding in a RIA for androstenedione. Conjugates and radioiodinated labels were prepared with either an ester or either chemical bridge. By using an antibody and the corresponding label with the heterologous bridge very sensitive assays were obtained.

  DOI：

  10.1016/0039-128x(81)90030-1
• 作为产物：
  描述：

  19-羟基雄甾-4-烯-3,17-二酮 在 dirhodium tetraacetate 氢氧化钾 作用下， 以 甲醇 、 苯 为溶剂， 反应 0.5h， 生成 2-[[(10S,13S)-13-甲基-3,17-二氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-10-基]甲氧基]乙酸
  参考文献：
  名称：

  A chemical approach to solving bridging phenomena in steroid radioimmunoassays

  摘要：

  Steroid radioimmunoassays (RIA) employ antibodies raised against a carrier protein-steroid conjugate. Individual antibodies may recognize the steroid, the protein or the chemical bridge used to join them together. Use of the same bridge in the tracer results in higher affinity binding of the tracer than the native ligand which in turn results in a loss of sensitivity and precision. We have greatly reduced bridge-binding in a RIA for androstenedione. Conjugates and radioiodinated labels were prepared with either an ester or either chemical bridge. By using an antibody and the corresponding label with the heterologous bridge very sensitive assays were obtained.

  DOI：

  10.1016/0039-128x(81)90030-1

文献信息

• [EN] CHEMILUMINESCENT ANDROSTENEDIONE CONJUGATES<br/>[FR] CONJUGUÉS D'ANDROSTÈNEDIONE CHIMIOLUMINESCENTS
  申请人：SIEMENS HEALTHCARE DIAGNOSTICS INC

  公开号：WO2018156925A1

  公开（公告）日：2018-08-30

  Chemiluminescent androstenedione conjugates are disclosed. These chemiluminescent androstenedione conjugates may be used as chemiluminescent tracers in immunoassays for the quantification and identification of certain analytes.

  发光雄烯二酮共轭物被披露。这些发光雄烯二酮共轭物可用作化学发光示踪剂，用于定量和鉴定特定分析物的免疫分析。
• CHEMILUMINESCENT ANDROSTENEDIONE CONJUGATES
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP3585438B1

  公开（公告）日：2021-11-10