N-(4-methoxylphenyl)-4,6-dimethyl-2-pyrimidinamine | 23951-85-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-methoxylphenyl)-4,6-dimethyl-2-pyrimidinamine
• 英文别名: 2-(4-methoxyanilino)-4,6-dimethylpyrimidine；(4,6-dimethyl-pyrimidin-2-yl)-(4-methoxy-phenyl)-amine；(4,6-Dimethyl-pyrimidin-2-yl)-(4-methoxy-phenyl)-amin；2-(4-Methoxy-anilino)-4,6-dimethyl-pyrimidin；N-(4-methoxyphenyl)-4,6-dimethylpyrimidin-2-amine
• CAS: 23951-85-1
• 化学式: C₁₃H₁₅N₃O
• 分子量: 229.282
• InChiKey: QWXCCRCTIXSUFC-UHFFFAOYSA-N

物化性质

• 熔点：
  88-89 °C
• 沸点：
  399.7±44.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-methoxyphenyl)-4,6-dimethylpyrimidine-2-thione 在 氨 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以35%的产率得到N-(4-methoxylphenyl)-4,6-dimethyl-2-pyrimidinamine
  参考文献：
  名称：

  Kashima, Choji; Katoh, Akira; Yokota, Yuko, Chemical and pharmaceutical bulletin, 1982, vol. 30, # 6, p. 1942 - 1946

  摘要：

  DOI：

文献信息

• One-Pot Two-Step Solvent-Free Rapid and Clean Synthesis of 2-(Substituted Amino)pyrimidines by Microwave Irradiation
  作者：Shyamaprosad Goswami、Anita Hazra、Subrata Jana

  DOI：10.1246/bcsj.82.1175

  日期：2009.9.15

  A series of diversely 2-(substituted amino)pyrimidines (along with ring substitution) has been synthesized under solvent- and catalyst-free microwave conditions from substituted guanidines and β-di...

  在无溶剂和无催化剂微波条件下，由取代胍和 β-二...
• Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
  作者：Cristina Campestre、György Keglevich、János Kóti、Luca Scotti、Carla Gasbarri、Guido Angelini

  DOI：10.1039/d0ra00833h

  日期：——

  2-anilinopyrimidines including novel derivatives has been obtained from 2-chloro-4,6-dimethylpyrimidine by aromatic nucleophilic substitution with differently substituted anilines under microwave conditions. The substituents had a significant impact on the course and efficiency of the reaction. The results reported herein demonstrate the efficacy of microwaves in the synthesis of the title heterocyclic compounds

  以2-氯-4,6-二甲基嘧啶为原料，在微波条件下用不同取代的苯胺进行芳香亲核取代，得到一系列2-苯胺嘧啶，包括新的衍生物。取代基对反应过程和效率有显着影响。与通过常规加热获得的结果相比，本文报道的结果证明了微波在标题杂环化合物的合成中的功效。所描述的 2-苯胺嘧啶具有潜在的生物活性。
• A novel hydride-mediated reductive rearrangement of amide: a facile synthesis of pyrimidyl and triazinyl amines
  作者：Xiang Chen、Jun Wu、Zhicai Shang、Meifeng Chen、Yanping Sun、Jing Lv、Meikang Lei、Peizhi Zhang

  DOI：10.1016/j.tetlet.2007.11.096

  日期：2008.1

  LiAlH4 and NaBH4 were found to mediate the conversion of 2-(pyrimidyl-2-ylsulfanyl)-N-arylbenzamides and 2-(triazinyl-2-ylsulfanyl)-N-arylbenzamides into pyrimidyl and triazinyl amines under notably mild conditions via a novel reductive rearrangement mechanism. These reactions invent a new route to prepare amines, which are a kind of important biologically active compounds and provide the first insight

  发现LiAlH 4和NaBH 4介导在温和的条件下，通过苯甲酰胺将2-（嘧啶基-2-基硫烷基）-N-芳基苯甲酰胺和2-（三嗪基-2-基硫烷基）-N-芳基苯甲酰胺转化为嘧啶基和三嗪基胺。新颖的还原性重排机制。这些反应发明了一种新的制备胺的途径，该胺是一种重要的生物活性化合物，为氢化物促进的酰胺还原性重排提供了首次见识。
• 71. Synthetic antimalarials. Part IV. 2-Phenylguanidino-4-aminoalkylamino-6-methylpyrimidines
  作者：F. H. S. Curd、F. L. Rose

  DOI：10.1039/jr9460000362

  日期：——
• FRANKE, F.;KLEPEL, M.;KRAUSE, G.;LEHMANN, H.;BRAEMER, B.
  作者：FRANKE, F.、KLEPEL, M.、KRAUSE, G.、LEHMANN, H.、BRAEMER, B.

  DOI：——

  日期：——