2-Methoxycyclohexanone oxime | 110808-77-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Methoxycyclohexanone oxime
• 英文别名: 1-(hydroxyimino)-2-methoxycyclohexane；Gqvinghnswasnt-sofgywhqsa-；(NE)-N-(2-methoxycyclohexylidene)hydroxylamine
• CAS: 110808-77-0
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: GQVINGHNSWASNT-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Methoxycyclohexanone oxime 在 L-Selectride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 Petroleum ether 为溶剂， 反应 4.0h， 生成 cis-N-(Diphenylphosphinyl)-2-methoxycyclohexylamine
  参考文献：
  名称：

  Stereoselective Hydride Reductions of Cyclic N-Diphenylphosphinyl Imines. Highly Diastereoselective Syntheses of Protected Primary Amines

  摘要：

  Reduction of N-diphenylphosphinyl imines of variously substituted cyclohexanones, cyclopentanones, and bicyclic ketones with lithium tri-sec-butylborohydride provides highly diastereoselective procedures for the syntheses of N-diphenylphosphinyl amines which represent protected primary amines that can be unmasked by mild acidic cleavage. Attack of cyclohexyl derivatives occurs almost exclusively via equatorial approach to yield axial amine derivatives while cyclopentyl and bicyclic imines are attacked from the less sterically encumbered faces.

  DOI：

  10.1021/jo00128a009
• 作为产物：
  描述：

  2-甲氧基环己酮 在 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 生成 2-Methoxycyclohexanone oxime
  参考文献：
  名称：

  Novel guanidinobenzamides

  摘要：

  公式IA和IB的化合物是新的，其中变量R1到R10具有以下数值。这些化合物在治疗肥胖和2型糖尿病等疾病方面具有用途，并可作为与药学上可接受的载体结合的药物制剂提供。

  公开号：

  US20020137939A1

文献信息

• Efficient functional group transformations on a cyclic nitroalkene system
  作者：Jih Ru Hwu、Naelong Wang

  DOI：10.1039/c39870000427

  日期：——

  Single-pot nitroalkene → cyanoaldehyde transformation, α-methoxy oxime formation, α- and β-alkylations of β-sulphenylated nitro compound, generation of β-sulphenylated silyl nitronate, and sequential Michael addition and Nef reaction have been accomplished in good to excellent yields.

  单锅硝基烯烃→氰醛的转化，α-甲氧基肟的形成，β-硫代苯基化的硝基化合物的α-和β-烷基化，β-硫代苯基化的甲硅烷基亚硝酸盐的生成以及依次的迈克尔加成和Nef反应均以优异的收率完成。
• [EN] NANOMATERIALS COMPRISING ESTER-LINKED ACETALS<br/>[FR] NANOMATÉRIAUX COMPRENANT DES ACÉTALS À LIAISON ESTER
  申请人：BEAM THERAPEUTICS INC

  公开号：WO2022140252A1

  公开（公告）日：2022-06-30

  The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

  本公开说明书描述了组合物、制剂、纳米颗粒（如脂质纳米颗粒）和/或纳米材料及其使用方法。
• Axial/equatorial populations in ?-hetero-substituted cyclohexanone Oximes andO-methyl oximes
  作者：Douglas S. Ribeiro、Paulo R. Olivato、Roberto Rittner

  DOI：10.1002/1097-458x(200008)38:8<627::aid-mrc680>3.0.co;2-m

  日期：2000.8

  Axial equatorial populations were determined for (E)-2-X-cyclohexanone oximes and O-methyl oxime ethers in chloroform by the Eliel method [X = F, Cl, Br, OCH3, N(CH3)(2), SCH3]. A novel approach is presented, which uses H-1 NMR data from the protons bonded to C-6. The conformational proportions were also obtained from the C-4 chemical shifts, the Z-isomer spectral parameters being taken as reference for calculation. For both series, all substituents adopt preferentially the axial conformation (86-96%), but the O-methyl oxime ethers present an enhanced axial population compared with the corresponding oximes, owing to the accepted occurrence of a pi(C=NOH)/sigma(CX)* stabilizing interaction. Copyright (C) 2000 John Wiley & Sons, Ltd.
• FUJIOKA, HIROMICHI;MIYAZAKI, MAKOTO;YAMANAKA, TAKESHI;YAMAMOTO, HIROFUMI;+, TETRAHEDRON LETT., 31,(1990) N1, C. 5951-5954
  作者：FUJIOKA, HIROMICHI、MIYAZAKI, MAKOTO、YAMANAKA, TAKESHI、YAMAMOTO, HIROFUMI、+

  DOI：——

  日期：——
• HWU JIH RU; WANG NAELONG, J. CHEM. SOC. CHEM. COMMUN.,(1987) N 6, 427-428
  作者：HWU JIH RU、 WANG NAELONG

  DOI：——

  日期：——

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