N-(2-hydroxyethyl)pyrrolidine N-oxide | 39650-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(2-hydroxyethyl)pyrrolidine N-oxide
• 英文别名: 2-(1-oxy-pyrrolidin-1-yl)-ethanol；2-(1-Oxidopyrrolidin-1-ium-1-yl)ethanol
• CAS: 39650-59-4
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: ZKMAYNUQMDMNTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxyethyl)pyrrolidine N-oxide 以 乙醇 为溶剂， 生成 phenylboronic acid phenyl ester 2-pyrrolidin-1-yl-ethyl ester
  参考文献：
  名称：

  Kliegel,W., Justus Liebigs Annalen der Chemie, 1972, vol. 763, p. 61 - 65

  摘要：

  DOI：

文献信息

• Synthese und thermisch induzierte umlagerung der diarylborchelate von N-(2-hydroxyalkyl)-N,N-dialkylamin-N-oxiden
  作者：Wolfgang Kliegel、Eckart Ahlenstiel

  DOI：10.1016/0022-328x(84)80698-1

  日期：1984.12

  Various diarylboron chelates of the cyclic B,N-betaine type (2, 7, 11) are synthesized from N-(2-hydroxyalkyl)-N,N-dialkylamine-N-oxides (1) and diarylboron reagents. They are rearranged in a thermally induced intramolecular redox reaction, during which the N-oxide is deoxygenated and the borinic acid moiety is oxidized to the state of boronic acid. The rearrangement products 3, 8 and 12 are converted

  环状的各种二芳基硼酸螯合物B，N -betaine型（2,7，11）从合成ñ - （2-羟烷基） - N，N- -dialkylamine- Ñ -oxides（1）和二芳基硼酸试剂。它们在热诱导的分子内氧化还原反应中重排，在此期间，N-氧化物被脱氧，而硼酸部分则被氧化成硼酸状态。通过与N-氧化物（1）再螯合，将重排产物3、8和12转化为新的B，N-甜菜碱型螯合物5和9。
• 1,4-dihydropyridine compounds as bradykinin antagonists
  申请人：——

  公开号：US20020161006A1

  公开（公告）日：2002-10-31

  The present invention relates to compounds of the formula 1 wherein each A is independently halo; Y is —(CH 2 ) m —, —C(O)— or —S(O)—; R 1 and R 2 are independently C 1-4 alkyl; R 3 is substituted azacycloalkyl etc.; R 4 is phenyl substituted at the 2-position with a substituent selected from substituted C 1-7 alkyl, substituted C 1-7 alkoxy, amine, etc; R 5 is hydrogen or C 1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.

  本发明涉及公式1的化合物，其中每个A独立地是卤素；Y是—（CH2）m—，—C（O）—或—S（O）—；R1和R2独立地是C1-4烷基；R3是取代的氮杂环烷基等；R4是苯基，在2位被取代，取代基为取代的C1-7烷基，取代的C1-7烷氧基，胺等；R5是氢或C1-4烷基；m为0、1或2；n为0、1、2、3、4或5。本发明还涉及包含这些化合物的制药组合物以及在治疗和预防炎症、哮喘、过敏性鼻炎、疼痛和其他疾病中使用这些化合物的用途。
• TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME
  申请人：Kai Hiroyuki

  公开号：US20130172317A1

  公开（公告）日：2013-07-04

  The present invention provides novel compounds having a P2X 3 and/or P2X 2/3 receptor antagonistic effect. A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein R h and R j are taken together to form a bond; R a and R b and/or R d and R e are taken together to form oxo or the like; R c is hydrogen, substituted or unsubstituted alkyl or the like; R f is —(CR 4a R 4b ) n —R 2 ; R 4a and R 4b are hydrogen, substituted or unsubstituted alkyl or the like; R 2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —R g is —X—R 3 ; —X— is —O—, —S— or the like; R 3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了具有P2X3和/或P2X2/3受体拮抗作用的新型化合物。一种具有镇痛作用或改善排尿障碍作用的药物组合物，包括式（I）的化合物：其中Rh和Rj结合形成键；Ra和Rb和/或Rd和Re结合形成氧化物或类似物；Rc是氢、取代或未取代的烷基或类似物；Rf是-(CR4aR4b)n-R2；R4a和R4b是氢、取代或未取代的烷基或类似物；R2是取代或未取代的环烷基或类似物；n是1到4的整数；-R是-X-R3；-X-是-O-、-S-或类似物；R3是取代或未取代的环烷基或类似物，或其药学上可接受的盐或其溶剂化物。
• Method of orienting polymer molecules
  申请人：MISSISSIPPI POLYMER TECHNOLOGIES, INC.

  公开号：EP1352731A2

  公开（公告）日：2003-10-15

  The present invention relates to a process for orienting the polymer molecules of an article comprising specific rigid-rod polymers by heating and stretching the article.

  本发明涉及一种工艺，通过加热和拉伸由特定硬棒聚合物组成的物品，使该物品的聚合物分子定向。
• METHOD OF PURIFYING N-(2-HYDROXYETHYL)-2-PYRROLIDONE
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP1375481A1

  公开（公告）日：2004-01-02

  A method for obtaining high purity N-(2-hydroxyethyl)-2-pyrrolidone satisfactory for use as an intermediate material for N-vinyl-2-pyrrolidone from a reaction liquid formed of a reaction between γ-butyrolactone and 2-aminoethanol, i.e., a liquid containing N-(2-hydroxyethyl) -2-pyrrolidone, compounds having boiling points lower than that of N-(2-hydroxyethyl)-2-pyrrolidone and compounds having boiling points higher than that of N-(2-hydroxyethyl)-2-pyrrolidone. The method is characterized by distilling said reaction liquid using a distillation column, whereby obtaining a liquid containing the compounds having the lower boiling points than that of N-(2-hydroxyethyl)-2-pyrrolidone and N-(2-hydroxyethyl)-2 -pyrrolidone as a distillate liquid from the column top and a liquid containing compounds having boiling points higher than that of N-(2-hydroxyethyl)-2-pyrrolidone as a bottom liquid.

  一种从γ-丁内酯和 2-氨基乙醇反应形成的反应液中获得满意的高纯度 N-(2-羟乙基)-2-吡咯烷酮以用作 N-乙烯基-2-吡咯烷酮中间体材料的方法，即、含有 N-(2-羟乙基)-2-吡咯烷酮、沸点低于 N-(2-羟乙基)-2-吡咯烷酮的化合物和沸点高于 N-(2-羟乙基)-2-吡咯烷酮的化合物的液体。该方法的特点是使用蒸馏塔蒸馏所述反应液，从而从塔顶获得含有沸点低于 N-(2-羟乙基)-2-吡咯烷酮和 N-(2-羟乙基)-2-吡咯烷酮的化合物的液体作为蒸馏液，以及含有沸点高于 N-(2-羟乙基)-2-吡咯烷酮的化合物的液体作为底液。