2-Phenyl-propionic acid 1-phenyl-ethyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Phenyl-propionic acid 1-phenyl-ethyl ester
• 英文别名: 1-Phenylethyl 2-phenylpropanoate
• 化学式: C₁₇H₁₈O₂
• 分子量: 254.329
• InChiKey: AGBRCAANXTWKLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯基丙酸 、 苏合香醇 在 O-(-)-menthyl hydrogen phosphorofluoridate 作用下， 反应 6.0h， 以57%的产率得到2-Phenyl-propionic acid 1-phenyl-ethyl ester
  参考文献：
  名称：

  在无溶剂条件下，氟磷酸催化羧酸与 1-芳烷基醇的缩合反应生成酯

  摘要：

  具有 L-薄荷基的氟代磷酸在无溶剂条件下催化羧酸与 1-芳基烷基醇之间的缩合反应，得到中等至高产率的酯...

  DOI：

  10.1246/cl.2009.668

文献信息

• Pyridine-3-carboxylic Anhydride (3-PCA): A Versatile, Practical, and Inexpensive Reagent for Condensation Reaction between Carboxylic Acids and Alcohols
  作者：Teruaki Mukaiyama、Setsuo Funasaka

  DOI：10.1246/cl.2007.326

  日期：2007.2

  A synthesis of carboxylic esters from various carboxylic acids and alcohols is successfully carried out by using a condensation reagent, pyridine-3-carboxylic anhydride (3-PCA). This reaction materialized synthesis of various carboxylic esters to be carried out under mild conditions by simple experimental procedure.

  通过使用缩合试剂吡啶-3-羧酸酐 (3-PCA)，可以成功地从各种羧酸和醇合成羧酸酯。该反应通过简单的实验程序，在温和的条件下实现了各种羧酸酯的合成。
• Oxidative decarboxylation of carboxylic acids by iron porphyrin - iodosylbenzene system
  作者：Masakatsu Komuro、Yoshio Nagatsu、Tsunehiko Higuchi、Masaaki Hirobe

  DOI：10.1016/s0040-4039(00)61242-x

  日期：1992.8

  An iodosylbenzene - iron tetraarylporphyrin catalyst system decarboxylated α-aryl carboxylic acids and α,α,α-trisubstituted acetic acids efficiently to give the corresponding alcohol and carbonyl derivatives.

  碘代苯-四芳基卟啉铁催化剂体系可有效地将α-芳基羧酸和α，α，α-三取代的乙酸脱羧，得到相应的醇和羰基衍生物。
• Phosphorofluoridic Acid-catalyzed Condensation Reaction of Carboxylic Acids with 1-Arylalkyl Alcohols Leading to Esters under Solvent-free Conditions
  作者：Toshiaki Murai、Nagisa Tanaka、Shinji Higashijima、Hidetoshi Miura

  DOI：10.1246/cl.2009.668

  日期：2009.7.5

  Phosphorofluoridic acid with an L-menthyl group catalyzed condensation reaction between carboxylic acids and 1-arylalkyl alcohols under solvent-free conditions to give esters in moderate to high yi...

  具有 L-薄荷基的氟代磷酸在无溶剂条件下催化羧酸与 1-芳基烷基醇之间的缩合反应，得到中等至高产率的酯...
• Parallel kinetic resolution of racemic 1-phenylethanol using quasi-enantiomeric combinations of carboxylic acids mediated by N,N′-dicyclohexylcarbodiimide and 3,5-lutidine
  作者：Najla Al Shaye、Andrew N. Boa、Elliot Coulbeck、Jason Eames

  DOI：10.1016/j.tetlet.2008.05.036

  日期：2008.7

  The parallel kinetic resolution of racemic 1-phenylethanol using an equimolar combination of quasienantiomeric 2-arylpropionic and butanoic acids mediated by a N,N'-dicyclohexylcarbodiimide (DCC)/3,5-lutidine coupling is discussed. The levels of diastereoselectivity were high leading to separable quasi-enantiomeric esters in good yield. (C) 2008 Elsevier Ltd. All rights reserved.
• The reaction of methyl phenyl ketene and 1-phenyl ethanol - observation of a negative ethalpy of activation
  作者：Joachim Jähme、Christoph Rüchardt

  DOI：10.1016/s0040-4039(00)88682-7

  日期：1982.1