2-methyl-1-(5,6,7,8-tetrahydronaphthalen-2-yl)propan-1-one | 116707-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-methyl-1-(5,6,7,8-tetrahydronaphthalen-2-yl)propan-1-one
• 英文别名: 2-methyl-1-(5,6,7,8-tetrahydro-[2]naphthyl)-propan-1-one；2-Methyl-1-(5,6,7,8-tetrahydro-[2]naphthyl)-propan-1-on；2-methyl-1-(5,6,7,8-tetrahydro-2-naphthalenyl)-1-propanone
• CAS: 116707-04-1
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: PKYHRNBZZLBTAA-UHFFFAOYSA-N

物化性质

• 沸点：
  334.3±31.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-1-(5,6,7,8-tetrahydronaphthalen-2-yl)propan-1-one 、 3-羟基-2-萘酸肼 以 乙醇 为溶剂， 反应 20.0h， 以76%的产率得到(E)-3-hydroxy-N'-(2-methyl-1-(5,6,7,8-tetrahydronaphthalen-2-yl)propylidene)-2-naphthohydrazide
  参考文献：
  名称：

  Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses

  摘要：

  A library of hydrazide derivatives was synthesized to target non-structural protein 1 of influenza A virus (NS1) as a means to develop anti-influenza drug leads. The lead compound 3-hydroxy-N-[(Z)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylideneamino]naphthalene-2-carboxamide, which we denoted as "HENC", was identified by its ability to increase the melting temperature of the effector domain (ED) of the NS1 protein, as assayed using differential scanning fluorimetry. A library of HENC analogs was tested for inhibitory effect against influenza A virus replication in MDCK cells. A systematic diversification of HENC revealed the identity of the R group attached to the imine carbon atom significantly influenced the antiviral activity. A phenyl or cyclohexyl at this position yielded the most potent antiviral activity. The phenyl containing compound had antiviral activity similar to that of the active form of oseltamivir (Tamiflu), and had no detectable effect on cell viability. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.10.063
• 作为产物：
  描述：

  1,2,3,4-四氢萘 、 异丁酰氯 在 aluminium chloride 作用下， 以 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 、 二氯甲烷 为溶剂， 生成 2-methyl-1-(5,6,7,8-tetrahydronaphthalen-2-yl)propan-1-one
  参考文献：
  名称：

  Process for preparing 1-indanones

  摘要：

  本发明涉及一种制备式I的1-吲哚酮的方法：其中R1、R2、R3、R4、R5和R6独立地代表H或C1-C20烃基或R1和R2或R2和R3或R3和R4和/或R5和R6与它们连接的碳原子一起形成饱和或不饱和的5-或6-成员环，所述烃基和/或所述环可选择地含有一个或多个杂原子，所述环可选择地被C1-C4烃基取代，所述方法包括将式II的化合物与氯化剂反应，然后与弗里德尔-克拉夫茨催化剂反应。该发明还涉及相应吲哚烯的制备。

  公开号：

  US20020077507A1

文献信息

• Process for preparing 1-indanones
  申请人：——

  公开号：US20020077507A1

  公开（公告）日：2002-06-20

  The present invention relates to a process for preparing 1-indanones of formula I: 1 and isomers thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 independently represent H or a C 1 -C 20 hydrocarbon group or R 1 and R 2 or R 2 and R 3 or R 3 and R 4 and/or R 5 and R 6 together with the carbon atoms to which they are attached form a saturated or unsaturated 5- or 6-membered ring, said hydrocarbon group and/or said ring optionally containing one or more hetero atoms, said ring optionally being substituted with a C 1 -C 4 hydrocarbon group, said process comprising reacting a compound of formula II: 2 wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 have the same meaning as defined above, with a chlorinating agent, followed by reaction with a Friedel-Crafts catalyst. The invention further relates to the preparation of the corresponding indenes.

  本发明涉及一种制备式I的1-吲哚酮的方法：其中R1、R2、R3、R4、R5和R6独立地代表H或C1-C20烃基或R1和R2或R2和R3或R3和R4和/或R5和R6与它们连接的碳原子一起形成饱和或不饱和的5-或6-成员环，所述烃基和/或所述环可选择地含有一个或多个杂原子，所述环可选择地被C1-C4烃基取代，所述方法包括将式II的化合物与氯化剂反应，然后与弗里德尔-克拉夫茨催化剂反应。该发明还涉及相应吲哚烯的制备。
• ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS
  申请人：TACHDJIAN Catherine

  公开号：US20130295261A1

  公开（公告）日：2013-11-07

  The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,

  本发明提供以下式子及其特定亚属或种类的异山梨酯衍生物，作为味道或口感调节剂，特别是让食品、饮料和其他食品组合物具有鲜美（鲜味）口感的调节剂、风味剂和风味增强剂。
• Coumaran derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0273647A1

  公开（公告）日：1988-07-06

  A compound of the formula wherein R is a lower alkyl group, R0 is hydrogen or an acyl group, R1 and R2 are lower alkyl groups which may optionally be substituted or wherein R1 and R2 are combined to form a butadienylene group which may optionally be substituted, R3 and R4 are hydrogen or alkyl groups which may 'optionally be substituted or wherein R3 and R4 are combined to form a polymethylene group, and R5 is a lower alkyl, aromatic or heterocyclic group which may optionally be substituted or a pharmaceutically acceptable salt thereof, exerts cardiovascular system improving action and antiallergic action and can be used as pharmaceutics, e.g. antithromotics, antiallergic agents etc.

  式中 R 为低级烷基，R0 为氢或酰基，R1 和 R2 为可选择被取代的低级烷基，或其中 R1 和 R2 结合形成可选择被取代的丁二烯基，R3 和 R4 为氢或可'选择被取代的烷基，或其中 R3 和 R4 结合形成聚亚甲基，R5 为可选择被取代的低级烷基、芳香族或杂环基，或其药学上可接受的盐的化合物，具有改善心血管系统和抗过敏作用，可用作药物，如抗肿瘤药、抗过敏药等。
• Barbot, Bulletin de la Societe Chimique de France, 1930, vol. <4> 47, p. 1314,1318
  作者：Barbot

  DOI：——

  日期：——
• PROCESS FOR PREPARING 1-INDANONES
  申请人：Akzo Nobel N.V.

  公开号：EP1337501A1

  公开（公告）日：2003-08-27