2-[[[4-[[(4,6-二甲基-2-嘧啶基)氨基]磺酰基]苯基]氨基]羰基]苯甲酸 | 94134-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[[[4-[[(4,6-二甲基-2-嘧啶基)氨基]磺酰基]苯基]氨基]羰基]苯甲酸
• 中文别名: {1-[叔-丁基(二甲基)甲硅烷基]-1H-吲哚-4-基}硼酸
• 英文名称: N-[4-(4,6-dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-phthalamic acid
• 英文别名: N-[4-(4,6-Dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-phthalamidsaeure；2-{[(4-{[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)amino]carbonyl}benzoic acid；2-(((4-(((4,6-Dimethyl-2-pyrimidinyl)amino)sulphonyl)phenyl)amino)carbonyl)benzoic acid；2-[[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]carbamoyl]benzoic acid
• CAS: 94134-30-2
• 化学式: C₂₀H₁₈N₄O₅S
• 分子量: 426.453
• InChiKey: ASNQBPSYZGXIDK-UHFFFAOYSA-N

物化性质

• 密度：
  1.475±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  147
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  苯酐 、 磺胺二甲嘧啶 生成 2-[[[4-[[(4,6-二甲基-2-嘧啶基)氨基]磺酰基]苯基]氨基]羰基]苯甲酸
  参考文献：
  名称：

  Deliwala; Rajagopalan, Proceedings - Indian Academy of Sciences, Section A, 1950, vol. 31, p. 117,119

  摘要：

  DOI：

文献信息

• Methods of Inhibiting Bacterial Virulence and Compounds Relating Thereto
  申请人：Sperandio Vanessa

  公开号：US20100048573A1

  公开（公告）日：2010-02-25

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.

  本发明涉及化合物和方法，用于治疗细菌感染。由于它们的作用机制不涉及杀死细菌或抑制它们的生长，这些化合物诱导细菌耐药性的潜力被最小化。通过抑制细菌的毒力，本发明提供了治疗细菌感染的新方法。
• CH242247
  申请人：——

  公开号：——

  公开（公告）日：——
• US8252841B2
  申请人：——

  公开号：US8252841B2

  公开（公告）日：2012-08-28
• [EN] METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO<br/>[FR] PROCÉDÉS D'INHIBITION DE LA VIRULENCE BACTÉRIENNE ET COMPOSÉS S'Y RAPPORTANT
  申请人：UNIV TEXAS

  公开号：WO2009088549A2

  公开（公告）日：2009-07-16

  The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.
• Deliwala; Rajagopalan, Proceedings - Indian Academy of Sciences, Section A, 1950, vol. 31, p. 117,119
  作者：Deliwala、Rajagopalan

  DOI：——

  日期：——