di(p-tolyl) sulphate | 42448-42-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: di(p-tolyl) sulphate
• 英文别名: di(p-tolyl) sulfate；sulfuric acid di-p-tolyl ester；Schwefelsaeure-di-p-tolylester；Di-p-tolyl-sulfat；ditolyl ether-sulphonic acid；Di-p-tolylsulfat；p-Methylphenylsulfat；bis(4-methylphenyl) sulfate
• CAS: 42448-42-0
• 化学式: C₁₄H₁₄O₄S
• 分子量: 278.329
• InChiKey: MCIFXROHNAOJEG-UHFFFAOYSA-N

物化性质

• 熔点：
  64-65 °C
• 沸点：
  410.5±38.0 °C(Predicted)
• 密度：
  1.271±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  di(p-tolyl) sulphate 、 苯基溴化镁 在 二氯化双(三环己基膦)镍(II) 、 三环己基膦 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以99%的产率得到4-甲基联苯
  参考文献：
  名称：

  Biaryl Construction through Kumada Coupling with Diaryl Sulfates as One-by-One Electrophiles under Mild Conditions

  摘要：

  Diaryl sulfates were successfully applied as one-by-one organo electrophiles in Kumada coupling to construct biaryls with the emission of harmless inorganic salts.

  DOI：

  10.1021/ol9028308
• 作为产物：
  描述：

  sodium 4-methylphenoxide 在 磺酰氯 、 苯 作用下， 生成 di(p-tolyl) sulphate
  参考文献：
  名称：

  Denivelle, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1934, vol. 199, p. 211

  摘要：

  DOI：

文献信息

• Cyclopentanone derivatives, method of synthesis and uses thereof
  申请人：Neuropharma S.A.

  公开号：EP1939192A1

  公开（公告）日：2008-07-02

  The present invention relates to cyclopentanone derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

  本发明涉及公式（I）的环戊酮衍生物，其合成方法及用途。具体来说，所披露的化合物已被证明是糖原合成酶激酶3β（GSK-3β）的抑制剂，GSK-3β已知参与不同疾病和病况，如阿尔茨海默病或非胰岛素依赖型糖尿病。本发明还涉及包含这些化合物的药物组合物。此外，本发明旨在将这些化合物用于制造治疗和/或预防GSK-3介导的疾病或病况的药物。
• Well-Defined Ruthenium(II) Carboxylate as Catalyst for Direct C–H/C–O Bond Arylations with Phenols in Water
  作者：Lutz Ackermann、Jola Pospech、Harish Kumar Potukuchi

  DOI：10.1021/ol300671y

  日期：2012.4.20

  [Ru(O2CMes)2(p-cymene)] enabled efficient direct arylations of unactivated C–H bonds with easily available, inexpensive phenols. Extraordinary chemoselectivity of the well-defined ruthenium catalyst set the stage for challenging C–H/C–O bond functionalizations to occur under solvent-free conditions as well as in water, and allowed first direct C–H bond arylations with user-friendly diaryl sulfates as electrophiles

  钌（II）羧酸盐络合物[Ru（O 2 CMes）2（p- Cymene）]使未活化的C–H键与容易获得的廉价酚有效地直接芳基化。明确定义的钌催化剂的非凡的化学选择性为挑战性的C–H / C–O键功能化在无溶剂条件下以及在水中的条件奠定了基础，并允许使用用户友好的二芳基首次进行直接的C–H键芳基化硫酸盐为亲电试剂。
• Mass and infrared spectra of diaryl and aryl alkyl sulfate diesters
  作者：G. Paulson、J. Bakke、J. Giddings、M. Simpson

  DOI：10.1002/bms.1200050206

  日期：1978.2

  The synthesis and the infrared and mass spectra of diaryl and aryl alkyl sulfate diesters are described. The mass spectra of these two classes of compounds consistently showed an intense molecular ion and two or three additional intense, diagnostic ions. Their infrared spectra also gave information useful for characterizing and differentiating these two classes of compounds.

  描述了二芳基和芳基烷基硫酸二酯的合成以及红外光谱和质谱图。这两类化合物的质谱图始终显示强分子离子和两个或三个其他强诊断离子。它们的红外光谱还提供了有助于表征和区分这两类化合物的信息。
• Synthesis of aryloxysulphoxonium salts
  作者：G. R. Chalkley、D. J. Snodin、G. Stevens、M. C. Whiting

  DOI：10.1039/j39700000682

  日期：——

  Aryloxysulphoxonium salts (tetrafluoroborates and hexafluorophosphates) have been prepared by the decomposition of arenediazonium salts in an excess of various compounds containing the sulphonyl grouping: sulphones and aryl esters, and alkylated amides of alkane- and arene-sulphonic acids and of sulphuric acid.

  芳氧磺鎓盐（四氟硼酸盐和六氟磷酸盐）是通过在过量的各种含磺酰基的化合物（包括砜和芳基酯，以及链烷烃和芳烃磺酸的烷基化酰胺）中分解芳构氮鎓盐而制得的。
• Selected acid generating agents and their use in processes for imaging radiation-sensitive elements
  申请人：——

  公开号：US20030219673A1

  公开（公告）日：2003-11-27

  An acid generating agent useful for imaging photosensitive elements selected from compounds of formulae (I), (II) and (III). 1 wherein R 1 is selected from the group consisting of an unsubstituted and substituted hydrocarbon or aryl group; wherein X is selected from the group consisting of oxygen, sulfur and selenium; wherein Y is selected from the group consisting of sulfur, selenium and tellurium; wherein Ar 1 is selected from the group consisting of an unsubstituted and substituted aryl group; wherein R 2 , R 3 and R 4 are individually selected from the group consisting of an unsubstituted and substituted hydrocarbon or aryl group or any two of them are bonded together to form a ring structure; and wherein R 5 and R 6 are individually selected from the group of an unsubstituted and substituted hydrocarbon or aryl group, or are bonded to each other to form a ring structure.

  一种酸发生剂，用于成像光敏元素，所选化合物的公式为（I），（II）和（III）。 其中，R1选自未取代和取代的烃基或芳基组； 其中，X选自氧、硫和硒组； 其中，Y选自硫、硒和碲组； 其中，Ar1选自未取代和取代的芳基组； 其中，R2、R3和R4分别选自未取代和取代的烃基或芳基组，或其中任意两个结合形成环状结构； 其中，R5和R6分别选自未取代和取代的烃基或芳基组，或结合形成环状结构。