3,3'-dimethoxy-biphenyl-4-ylamine | 146819-55-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-dimethoxy-biphenyl-4-ylamine
• 英文别名: 3,3'-Dimethoxy-biphenyl-4-ylamin；2-Methoxy-4-(3-methoxyphenyl)aniline
• CAS: 146819-55-8
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: GCJCNFYTHYPWQM-UHFFFAOYSA-N

物化性质

• 沸点：
  359.1±27.0 °C(Predicted)
• 密度：
  1.118±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-环戊烯-1,2-二羧酸酐 、 3,3'-dimethoxy-biphenyl-4-ylamine 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 2-((3,3'-dimethoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
  参考文献：
  名称：

  Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

  摘要：

  A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.10.021
• 作为产物：
  描述：

  N-(3,3'-dimethoxy-biphenyl-4-yl)-acetamide 生成 3,3'-dimethoxy-biphenyl-4-ylamine
  参考文献：
  名称：

  Über die Synthese methylsubstituierter P-Oligopenylene. 5. Mitteilung

  摘要：

  AbstractUnsubstituierte p‐Oligophenylene sind sehr schwer löslich. Die Löslichkeit dieser substanzen kann durch Substitution mit Methylgruppen verbessert werden.Für die Synthese methylsubstituierter p‐Oligophenylence wurden verschiedene Verfahren herangezogen.Durch ULIMANN‐Kondensation entsprechender Jodaryle konnten zwei substitutionsisomere Tettamethyl‐p‐quaterphenyle, ein Tetramethoxy‐p‐quaterphenyl und ein Tetramethyl‐p‐sexiphenyl synthetisiert werden.Über die Carbonyladdition aromatischer metallorganischer Verbindungen an cyclische Diketone wurden über hydroaromatische Zwischenstufen ein Dimethyl‐p‐terphenyl, ein Tetramethyl‐p‐ quinquiphenul, zwei substitutionsisomere Dimethyl‐p‐quaterphenyle und ein Tetramethyl‐p‐sexiphenyl erhalten.Mit der N‐Nitroso‐acetylarylamin‐Reaktion gelang die Synthese eines weiteren Dimethyl‐p‐quaterpyenyls.An dem Dimethyl‐p‐terphenyl wurden elektrophile Substitutionsreaktionen studiert. Dabei ergab sich, daß die Substituenten bevorzugt die p‐Stellung aufsuchen.Die Bencnnung dieser Verbindungen wird nach einem neuen Bezifferungs‐Schema vorgenommen.Methylsubstituierte p‐Oligophenylene besitzen gegenüber den unsubstituierten Grundkörpern ausgeprägte LoUslichkeitseigenschaften. Der Löslichkeitsunterschied kann mehrere Zehnerpotenzen ausmachen.

  DOI：

  10.1002/macp.1959.020290115

文献信息

• CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME
  申请人：PI R & D Co. Ltd

  公开号：EP1614704A1

  公开（公告）日：2006-01-11

  A novel polyimide which retains the characteristics of polyimides, that is, excellent heat resistance, electrical insulation and chemical resistance, of which dielectric constant is lower than those of the known polyimides, as well as a composition containing the same and a process for producing the same, is disclosed. The polyimide of the present invention is a cross-linked polyimide having a dielectric constant of not more than 2,7, which was produced by polycondensing (a) tetramine(s), (a) tetracarboxylic dianhydride(s) and (an) aromatic diamine(s) in the presence of a catalyst.

  本发明公开了一种新型聚酰亚胺，它保留了聚酰亚胺的特性，即优异的耐热性、电绝缘性和耐化学性，其介电常数低于已知聚酰亚胺的介电常数，还公开了含有这种聚酰亚胺的组合物和生产这种聚酰亚胺的工艺。本发明的聚酰亚胺是一种介电常数不超过 2.7 的交联聚酰亚胺，它是通过在催化剂存在下将(a)四胺、(a)四羧酸二酐和(an)芳香族二胺缩聚而成。
• Polyimide solution compositions and process for preparing same
  申请人：Itatani, Hiroshi

  公开号：EP0604319B1

  公开（公告）日：1999-04-28
• Crosslinked polyimide, composition comprising the same and method for producing the same
  申请人：Itatani Hiroshi

  公开号：US20070106056A1

  公开（公告）日：2007-05-10

  A novel polyimide which retains the characteristics of polyimides, that is, excellent heat resistance, electrical insulation and chemical resistance, of which dielectric constant is lower than those of the known polyimides, as well as a composition containing the same and a process for producing the same, is disclosed. The polyimide of the present invention is a cross-linked polyimide having a dielectric constant of not more than 2.7, which was produced by polycondensing (a) tetramine(s), (a) tetracarboxylic dianhydride(s) and (an) aromatic diamine(s) in the presence of a catalyst.
• CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND PROCESS FOR PRODUCING THE SAME
  申请人：ITATANI Hiroshi

  公开号：US20110136061A1

  公开（公告）日：2011-06-09

  A novel polyimide which retains the characteristics of polyimides, that is, excellent heat resistance, electrical insulation and chemical resistance, of which dielectric constant is lower than those of the known polyimides, as well as a composition containing the same and a process for producing the same, is disclosed. The polyimide of the present invention is a cross-linked polyimide having a dielectric constant of not more than 2.7, which was produced by polycondensing (a) tetramine(s), (a) tetracarboxylic dianhydride(s) and (an) aromatic diamine(s) in the presence of a catalyst.
• US5502143A
  申请人：——

  公开号：US5502143A

  公开（公告）日：1996-03-26