2-(1-Methyl-2-hydroxy-ethylamino)-1-(2-naphthyl)-ethanol | 16367-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(1-Methyl-2-hydroxy-ethylamino)-1-(2-naphthyl)-ethanol
• 英文别名: 2-[2-(naphthalene-2-yl)-2-hydroxyethylamino]-propan-1-ol；2-[2-(naphthalen-2-yl)-2-hydroxyethylamino]-propan-1-ol；2-[(2-Hydroxy-2-naphthalen-2-ylethyl)amino]propan-1-ol
• CAS: 16367-37-6
• 化学式: C₁₅H₁₉NO₂
• mdl: MFCD13170947
• 分子量: 245.321
• InChiKey: FXGXJYXVRSVSCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴代-2-乙酰基萘 在 sodium tetrahydroborate 、 二甲基亚砜 作用下， 生成 2-(1-Methyl-2-hydroxy-ethylamino)-1-(2-naphthyl)-ethanol
  参考文献：
  名称：

  β-肾上腺素能阻断剂。I. Pronethalol和2-氨基-1-（2-萘基）乙醇的相关N-烷基和N-芳烷基衍生物。

  摘要：

  DOI：

  10.1021/jm00311a020

文献信息

• THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN
  申请人：Sosei R&D Ltd.

  公开号：EP1896393A1

  公开（公告）日：2008-03-12
• Treatment of Inflammatory Disorders and Pain
  申请人：Baxter Andrew Douglas

  公开号：US20080306162A1

  公开（公告）日：2008-12-11

  A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R 1 is aryl or heteroaryl optionally substituted with R 5 ; R 2 is H, alkyl or CH 2 OH and can be part of a ring with R 4 ; R 3 is H, alkyl or CH 2 OH and can be part of a ring with R 4 ; R 4 is H or alkyl or CH 2 (when forming part of a ring with R 2 or R 3 ); and R 5 is alkyl, CF 3 , OH, Oalkyl, OCOalkyl, CONH 2 , CN, F, Cl, Br, I, NH 2 , NHCHO, NHCONH 2 , NHSO 2 alkyl, CONH 2 , SOMe, CH 2 OH or OCONalkyl 2 ; or a salt thereof.
• [EN] THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN<br/>[FR] TRAITEMENT DE TROUBLES ET DE DOULEURS INFLAMMATOIRES
  申请人：SOSEI R & D LTD

  公开号：WO2007003896A1

  公开（公告）日：2007-01-11

  [EN] A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R₁ is aryl or heteroaryl optionally substituted with R₅; R₂ is H, alkyl or CH₂OH and can be part of a ring with R₄; R₃ is H, alkyl or CH₂OH and can be part of a ring with R₄; R₄ is H or alkyl or CH₂ (when forming part of a ring with R₂ or R₃); and R₅ is alkyl, CF₃, OH, Oalkyl, OCOalkyl, CONH₂, CN, F, Cl, Br, I, NH₂, NO₂, NHCHO, NHCONH₂, NHSO₂alkyl, CONH₂, SOMe, CH₂OH or OCONalkyl₂; or a salt thereof.
  [FR] L'invention concerne un composé qui est utile dans le traitement ou la prévention d'une affection telle qu'une douleur, qui est associée à la prolifération de cellules T ou qui est provoquée par des cytokines pro- et/ou anti-inflammatoires, selon la formule (I) dans laquelle R₁ est un aryle ou un hétéroaryle éventuellement substitué par R₅ ; R₂ est H, un alkyle ou CH₂OH et peut faire partie d'un anneau avec R₄ ; R₃ est H, un alkyle ou CH₂OH et peut faire partie d'un anneau avec R₄ ; R₄ est H ou un alkyle ou CH₂ (lorsqu'il constitue un anneau avec R₂ ou R₃) ; et R₅ est un alkyle, CF₃, OH, Oalkyle, OCOalkyle, CONH₂, CN, F, Cl, Br, I, NH₂, NO₂, NHCHO, NHCONH₂, NHSO₂alkyle, CONH₂, SOMe, CH₂OH ou OCONalkyle₂ ; ou un sel de ceux-ci.
• .beta.-Adrenergic blocking agents. I. Pronethalol and related N-alkyl and N-aralkyl derivatives of 2-amino-1-(2-naphthyl)ethanol
  作者：Ralph Howe、A. F. Crowther、J. S. Stephenson、B. S. Rao、L. H. Smith

  DOI：10.1021/jm00311a020

  日期：1968.9