3-hydroxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy | 170641-96-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-hydroxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy
• 英文别名: 2,2,5,5-tetramethyl-pyrrolidine-1,3-diol；1-Hydroxy-2,2,5,5-tetramethylpyrrolidin-3-ol
• CAS: 170641-96-0
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: SVZMHHSIOBTAHI-UHFFFAOYSA-N

物化性质

• 沸点：
  239.8±29.0 °C(Predicted)
• 密度：
  1.057±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy 在 C₆H₃(CPh₃)C(CH₃)PhCH₂C(CH₃)2NO* 作用下， 以 正己烷 为溶剂， 生成 3-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl
  参考文献：
  名称：

  位阻羟胺-硝酰基体系中氢原子的交换反应

  摘要：

  测定了喹啉、咪唑啉、吡咯烷和哌啶系列的空间位阻硝酰基自由基-羟胺以及二芳基羟胺体系中氢原子的直接和反向交换反应的速率常数。建立了水胺还原能力的量表。低同位素效应值是羟胺-硝酰基自由基体系中氢交换反应的典型特征。

  DOI：

  10.1007/bf02495549
• 作为产物：
  描述：

  3-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl 在 C₆H₃(CPh₃)C(CH₃)PhCH₂C(CH₃)2N(OH) 作用下， 以 正己烷 为溶剂， 生成 3-hydroxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy
  参考文献：
  名称：

  位阻羟胺-硝酰基体系中氢原子的交换反应

  摘要：

  测定了喹啉、咪唑啉、吡咯烷和哌啶系列的空间位阻硝酰基自由基-羟胺以及二芳基羟胺体系中氢原子的直接和反向交换反应的速率常数。建立了水胺还原能力的量表。低同位素效应值是羟胺-硝酰基自由基体系中氢交换反应的典型特征。

  DOI：

  10.1007/bf02495549

文献信息

• BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS
  申请人：International Business Machines Corporation

  公开号：US20160220705A1

  公开（公告）日：2016-08-04

  Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).

  具有顺磁性、两性亲疏性、生物相容性的聚合物已经制备好，其中包含一个带有顺磁性有机自由基的碳酸酯重复单元，更具体地说是一个亚硝基自由基。这种自由基聚合物可以通过将带有活性酯侧链的前体聚合物与带有自由基的亲核试剂处理而一步制备而成。前体聚合物可以通过有机催化的环氧化聚合（ROP）来制备，该环氧化单体带有活性酯侧链。这种自由基聚合物可能是无毒且部分可生物降解的。这种自由基聚合物在医学成像应用中可用作增强对比剂，和/或作为治疗医疗状况的治疗剂。这种自由基聚合物还可以作为治疗剂（例如药物）和/或医学图像增强剂（例如NIRF染料）的载体。
• Drug Resistance Reversal In Neoplastic Disease
  申请人：Patil Ghanshyam

  公开号：US20080200405A1

  公开（公告）日：2008-08-21

  The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.

  本发明涉及用于阻止或逆转肿瘤性疾病化疗耐药效应的化合物、组合物和方法。具体描述了羟胺的使用。
• [EN] SULFONATED NITROPHENOLS AS POLYMERIZATION INHIBITORS<br/>[FR] NITROPHÉNOLS SULFONÉS EN TANT QU'INHIBITEURS DE LA POLYMÉRISATION
  申请人：CHEMTURA CORP

  公开号：WO2006036426A1

  公开（公告）日：2006-04-06

  Disclosed herein is a method for inhibiting and retarding the premature polymerization and the polymer growth of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of at least one inhibitor that is a sulfonated nitrophenol of the formula: (I) wherein: R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkyl, NO2, and S03H, provided that at least one of R,, R2, and R3 is NO2 and at least one of R1, R2, and R3 is SO3H. In a preferred embodiment, at least one additional inhibitor selected from the group consisting of nitroxyl compounds, nitrosoanilines, nitrophenols, amines, and mixtures thereof is also added.

  本文揭示了一种抑制和延缓乙烯基不饱和单体的聚合物的过早聚合和聚合物生长的方法，包括向所述单体中添加至少一种抑制剂，其为公式（I）的磺化硝基苯酚的有效量：其中：R1、R2和R3是独立选择自氢、烷基、NO2和S03H的群组，前提是R1、R2和R3中至少有一个是NO2，且R1、R2和R3中至少有一个是SO3H。在优选实施例中，还添加了至少一种来自亚硝基化合物、亚硝基苯胺、硝基苯酚、胺和它们的混合物的附加抑制剂。
• Blends of quinone alkide and nitroxyl compounds and polymerization inhibitors
  申请人：——

  公开号：US20040010159A1

  公开（公告）日：2004-01-15

  Disclosed herein is a method for inhibiting the premature polymerization of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of: A) at least one nitroxyl compound, and B) at least one quinone alkide compound having an electron-withdrawing group at the 7-position. Additionally, a composition is disclosed that comprises: A) at least one nitroxyl compound, and B) at least one quinone alkide compound having an electron-withdrawing group at the 7-position.

  本公开涉及一种抑制乙烯基不饱和单体的过早聚合的方法，包括向所述单体中添加有效量的：A) 至少一种亚硝基化合物，和B) 在7位具有电子吸引基团的至少一种醌烯化合物。此外，还公开了一种包括：A) 至少一种亚硝基化合物，和B) 在7位具有电子吸引基团的至少一种醌烯化合物的组合物。
• [EN] SULFONATED PHENOLS WITH NITROPHENOLS AS POLYMERIZATION INHIBITORS<br/>[FR] PHENOLS SULFONES AVEC NITROPHENOLS COMME INHIBITEURS DE POLYMERISATION
  申请人：CHEMTURA CORP

  公开号：WO2006036274A1

  公开（公告）日：2006-04-06

  Disclosed herein is a method for inhibiting the premature polymerization and the polymer growth of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a combination of (A) at least one inhibitor that is a sulfonated phenol of the formula (I): wherein (1) R2 is selected from the group consisting of hydrogen and hydrocarbyl; and (2) R1 and R3 are independently selected from the group consisting of hydrogen and SO3H, provided that at least one of R1 and R3 is SO3H; (B) at least one inhibitor that is a nitrophenol; and, optionally, (C) an inhibitor selected from the group consisting of nitroxyl compounds and nitrosoanilines; and (D) an amine.

  本文公开了一种抑制乙烯基不饱和单体的过早聚合和聚合生长的方法，包括向该单体中添加以下组合物的有效量：（A）至少一种为公式（I）的磺化酚抑制剂，其中（1）R2选自氢和烃基组成的群体；（2）R1和R3独立地选自氢和SO3H组成的群体，但其中至少一个为SO3H；（B）至少一种为硝基酚的抑制剂；以及可选地，（C）从硝基氧化物化合物和硝基苯胺组成的群体中选择的抑制剂；和（D）胺。