benzo[g]quinazoline | 260-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: benzo[g]quinazoline
• 英文别名: Benzo[g]chinazolin；Benzo[g]quinazoline
• CAS: 260-38-8
• 化学式: C₁₂H₈N₂
• 分子量: 180.209
• InChiKey: VFFLLOJLQMPSQE-UHFFFAOYSA-N

物化性质

• 沸点：
  358.7±11.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)
• 熔点：
  160 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  马来酰亚胺 、 benzo[g]quinazoline 在 xylene 作用下， 生成 optically inactive 5,10,11,12-tetrahydro-5,10-pyrrolo[3,4]etheno-benzo[g]quinazoline-13,15-dione
  参考文献：
  名称：

  Etienne; Legrand, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1951, vol. 232, p. 1223

  摘要：

  DOI：
• 作为产物：
  描述：

  1H-苯并[g]喹唑啉-4-酮 在 Lindlar's catalyst 、 lead(II) oxide 、 氯苯 、 三氯氧磷 作用下， 生成 benzo[g]quinazoline
  参考文献：
  名称：

  Etienne; Legrand, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1949, vol. 229, p. 220

  摘要：

  DOI：

文献信息

• NOVEL ORGANIC HETEROCYCLIC COMPOUND AND LIGHT-EMITTING DEVICE COMPRISING SAME
  申请人：SFC CO., LTD.

  公开号：US20180072753A1

  公开（公告）日：2018-03-15

  The present invention relates to an organic light-emitting compound represented by [Chemical Formula A] and an organic light-emitting device. In Chemical Formula, A, X, Y, Z, and the substituents R 1 to R 8 , and R 11 to R 20 are as defined in the specification.

  本发明涉及一种由[化学公式A]表示的有机发光化合物以及一种有机发光器件。在化学公式中，A、X、Y、Z以及取代基R1至R8和R11至R20如说明书中所定义。
• POLYMERIZABLE COMPOUND AND OPTICAL ISOMER
  申请人：DIC Corporation

  公开号：US20180022716A1

  公开（公告）日：2018-01-25

  The present invention provides a polymerizable compound having high storage stability without causing crystal precipitation when added to a polymerizable composition. The present invention also provides a polymerizable composition containing the compound. When the filmy polymer produced through polymerization of the polymerizable composition is irradiated with UV light, it hardly discolors or peels from substrate. Further, the present invention provides a polymer produced through polymerization of the polymerizable composition and an optically anisotropic body using the polymer.

  本发明提供了一种聚合物化合物，具有高储存稳定性，添加到聚合物化合物时不会导致结晶沉淀。本发明还提供了含有该化合物的聚合物化合物。当通过聚合物化合物的聚合产生薄膜状聚合物时，若用紫外光照射，它几乎不会变色或脱落。此外，本发明提供了通过聚合物化合物的聚合产生的聚合物，以及使用该聚合物的光学各向异性体。
• POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
  申请人：DIC Corporation

  公开号：US20180002276A1

  公开（公告）日：2018-01-04

  In light of requests to reduce or reverse the wavelength dispersion of the birefringence of a phase-retardation film in order to increase the viewing angle of a liquid crystal display, the present invention provides a polymerizable compound that reduces, for example, the likelihood of crystals precipitating in a polymerizable composition including the polymerizable compound and enables the polymerizable composition to have high preservation stability and a polymerizable composition including the polymerizable compound which reduces the likelihood of inconsistencies being formed in a film-like polymer produced by polymerizing the polymerizable composition. Another object of the present invention is to provide a polymer produced by polymerizing the polymerizable composition and an optically anisotropic body including the polymer.

  鉴于要求减少或逆转相位延迟膜的双折射波长色散，以增加液晶显示器的视角，本发明提供了一种可聚合化合物，例如减少聚合物化合物中晶体沉淀的可能性，并使聚合物化合物具有高保存稳定性以及包括减少聚合物化合物聚合产生的膜状聚合物中不一致性的可能性的聚合物化合物。本发明的另一个目的是提供通过聚合聚合物化合物产生的聚合物以及包括该聚合物的光学各向异性体。
• Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines
  申请人：American Home Products Corporation

  公开号：US20020091273A1

  公开（公告）日：2002-07-11

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  该发明涉及一种用于选择性合成4,6,7,8-取代苯并[g]喹啉-3-碳腈和4,6,7,8-取代苯并[g]喹唑啉以及它们的中间体的方法。该发明衍生的化合物可用于治疗由这些PTK的失调导致的各种疾病，更具体地说，它们是抗癌剂，可用于治疗哺乳动物的癌症。此外，该发明衍生的化合物可用于治疗哺乳动物的多囊肾病。
• Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
  申请人：Berger Maarten Dan

  公开号：US20060041127A1

  公开（公告）日：2006-02-23

  This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

  本发明涉及一种4,6,7,8-取代苯并[g]喹啉-3-羧腈和4,6,7,8-取代苯并[g]喹唑啉的区域选择性合成方法及其中间体。本发明所得化合物可用于治疗多种疾病，这些疾病是由这些PTK的失调所致，更具体地说，它们是抗癌剂，可用于治疗哺乳动物的癌症。此外，本发明所得化合物还可用于治疗哺乳动物的多囊肾病。