4-[(5,6-Dimethoxy-1-indenon)-2-yl]methyl-1-ethoxycarbonylpiperidine | 120013-43-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 4-[(5,6-Dimethoxy-1-indenon)-2-yl]methyl-1-ethoxycarbonylpiperidine
• 英文别名: Ethyl 4-[(5,6-dimethoxy-1-oxoinden-2-yl)methyl]piperidine-1-carboxylate
• CAS: 120013-43-6
• 化学式: C₂₀H₂₅NO₅
• 分子量: 359.422
• InChiKey: GZZPJGXWQNRCNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-1-ethoxycarbonylpiperidine 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 在 N-溴代丁二酰亚胺(NBS) 、 碳酸氢钠 、 过氧化苯甲酰 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 以56%的产率得到4-[(5,6-Dimethoxy-1-indenon)-2-yl]methyl-1-ethoxycarbonylpiperidine
  参考文献：
  名称：

  Cyclic amine compounds with activity against acetylcholinesterase

  摘要：

  一种环状胺化合物的定义式为：##STR1## 其中J为茚基、茚酰基、茚烯基、茚酰亚基、茚二酮基、四酰基基、苯并戊二酰基、茚醇基或其二价基团，K为苯基、芳基烷基或肉桂基，B为--(CHR22)r--，其中R22为H或甲基，--CO--(CHR22)r--，.dbd.(CH--CH.dbd.CH)b--，.dbd.CH--(CH2)c--或.dbd.(CH--CH)d.dbd.，并且包括T和Q的环为哌啶。该化合物可用于治疗老年性痴呆症。

  公开号：

  US04895841A1

文献信息

• Piperidine and piperazine compounds for use in the treatment of Alzheimer
  申请人：Eisai Co., Ltd.

  公开号：EP1116716A1

  公开（公告）日：2001-07-18

  A cyclic amine compound or a salt thereof is defined by the formula: in which J is (a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl; (b) a monovalent or divalent group, in which the phenyl may have a substituent(s) selected from the group consisting of (1) indanyl, (2) indanonyl, (3) indenyl, (4) indenonyl, (5) indanedionyl, (6) tetralonyl, (7) benzosuberonyl, (8) indanolyl and (9) C6H5-CO-CH(CH3)-; (c) a monovalent group derived from a cyclic amide compound; (d) a lower alkyl; or (e) a group of R21-CH=CH- in which R21 is hydrogen or a lower alkoxycarbonyl; B is a bridging group; T is a nitrogen; Q is nitrogen, carbon or >N→0; q is an integer of 1 to 3; K is hydrogen, an optionally substituted phenyl group, an arylalkyl in which the phenyl may have a substituent, cynnamyl, a lower alkyl, pyridylmethyl, a cycloalkylalkyl, adamantanemethyl, furylmethyl, a cycloalkyl, a lower alkoxycarbonyl or an acyl; and ----¯ shows a single bond or a double bond. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  一个环状胺化合物或其盐的定义公式为：其中J是(a) 选择自(1) 苯基，(2) 吡啶基，(3) 吡唑基，(4) 喹啉基，(5) 环己基，(6) 喹噁啉基和(7) 呋喃基的可选取代基；(b) 一价或二价基团，其中苯基可以具有选自(1) 吲哚基，(2) 吲哚基丙烷基，(3) 茚基，(4) 茚基丙烷基，(5) 吲哚二酮基，(6) 四酮基，(7) 苯并戊二酰基，(8) 吲哚醇基和(9) C6H5-CO-CH(CH3)-的取代基；(c) 源自环状酰胺化合物的一价基团；(d) 较低的烷基；或(e) R21-CH=CH-中R21是氢或较低的烷氧羰基的基团；B是桥接基团；T是氮；Q是氮、碳或>N→0；q是1到3的整数；K是氢、可选取代苯基、芳基烷基，其中苯基可以具有取代基，肉桂酸基，较低的烷基，吡啶甲基，环状烷基烷基，金刚烷基甲基，呋喃基甲基，环状烷基，较低的烷氧羰基或酰基；而----¯表示单键或双键。该化合物用于制备药物组合物和用于治疗老年痴呆症的药物。
• 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease
  申请人：Eisai Co., Ltd.

  公开号：EP0296560A2

  公开（公告）日：1988-12-28

  A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, = (CH-CH = CH)b-, = CH-(CH2)c- or = (CH-CH)d = and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  环胺化合物的定义如式所示： 其中 J 是茚基、茚壬基、茚基、茚烯基、茚二壬基、四壬基、苯并琥珀酰基、 茚醇基或其二价基团，K 是苯基、B是-(CHR22)r-，R22是H或甲基、-CO-(CHR22)r-、＝(CH-CH＝CH)b-、＝CH-(CH2)c-或＝(CH-CH)d＝，包括T和Q的环是哌啶。该化合物可用于制备药物组合物和对老年痴呆症有效的药物。
• 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease
  申请人：Eisai Co., Ltd.

  公开号：EP0579263A1

  公开（公告）日：1994-01-19

  Cyclic amines are provided of the formula: wherein J is: (a) a group, substituted or unsubstituted, selected from the group consisting of (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl; (b) a monovalent group derived from a cyclic amide compound; (c) a lower alkyl or (d) a group of R²¹-CH=CH- in which R²¹ is hydrogen or a lower alkoxycarbonyl;    K is phenyl, an arylalkyl or cynnamyl;    B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-(CH2)c- or =(CH-CH)d=; and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  环胺的化学式为 其中 J 为 (a) 一个取代或未取代的基团，选自由(1)苯基、(2)吡啶基、(3)苄基、 (4)喹啉基、(5)环己基、(6)喹喔啉基和(7)呋喃基组成的组； (b) 由环酰胺化合物衍生的一价基团； (c) 低级烷基或 (d) R²¹-CH=CH- 的基团，其中 R²¹ 是氢或低级烷氧羰基； K 是苯基、芳烷基或炔酰胺基； B是-(CHR22)r-，R22是氢或甲基，-CO-(CHR22)r-，=(CH-CH=CH)b-，=CH-(CH2)c-或=(CH-CH)d=；包括T和Q的环是哌啶。 该化合物可用于制备药物组合物和对老年痴呆症有效的药物。
• 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents
  申请人：Eisai Co., Ltd.

  公开号：EP0673927A1

  公开（公告）日：1995-09-27

  A cyclic amine compound is defined by the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-(CH2)c- or =(CH-CH)d= and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  环胺化合物的定义如下式所示 其中 J 是茚基、茚壬基、茚基、茚烯基、茚二壬基、四壬基、苯并琥珀酰基、 茚醇基或其二价基团，K 是苯基、B是-(CHR22)r-，R22是H或甲基、-CO-(CHR22)r-、=(CH-CH=CH)b-、=CH-(CH2)c-或=(CH-CH)d=，包括T和Q的环是哌啶。该化合物可用于制备药物组合物和对老年痴呆症有效的药物。
• 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation
  申请人：Eisai Co., Ltd.

  公开号：EP0742207A1

  公开（公告）日：1996-11-13

  Processes are provided for preparing cyclic amine compounds defined within the formula: in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is -(CHR22)r-, R22 being H or methyl, -CO-(CHR22)r-, =(CH-CH=CH)b-, =CH-(CH2)c- or =(CH-CH)d= and the ring including T and Q is piperidine. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.

  提供了制备式中定义的环胺化合物的工艺： 其中 J 是茚基、茚壬基、茚满基、茚二壬基、四壬基、苯并琥珀酰基、茚醇基或其二价基团，K 是苯基、B是-(CHR22)r-，R22是H或甲基、-CO-(CHR22)r-、=(CH-CH=CH)b-、=CH-(CH2)c-或=(CH-CH)d=，包括T和Q的环是哌啶。该化合物可用于制备药物组合物和对老年痴呆症有效的药物。