2-(3-tolylamino)-1-butanol | 1060700-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-tolylamino)-1-butanol
• 英文别名: 2-(3-tolylamino)butan-1-ol；2-(3-Methylanilino)butan-1-ol
• CAS: 1060700-62-0
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: NFMNSHYBVOZOFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-1-丁醇 、 间碘甲苯 在 copper(l) chloride 、 potassium hydroxide 作用下， 反应 8.0h， 以64%的产率得到2-(3-tolylamino)-1-butanol
  参考文献：
  名称：

  Solvent-free copper-catalyzed N-arylation of amino alcohols and diamines with aryl halides

  摘要：

  A simple and mild method for the coupling of aryl halides with amino alcohols and diamines is described. The reactions can be performed under ligand-free and solvent-free conditions, and generate the products in good yield. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.130

文献信息

• Solvent-free copper-catalyzed N-arylation of amino alcohols and diamines with aryl halides
  作者：Huiqing Yin、Ming Jin、Wei Chen、Chen Chen、Likang Zheng、Ping Wei、Shiqing Han

  DOI：10.1016/j.tetlet.2011.12.130

  日期：2012.3

  A simple and mild method for the coupling of aryl halides with amino alcohols and diamines is described. The reactions can be performed under ligand-free and solvent-free conditions, and generate the products in good yield. (C) 2012 Elsevier Ltd. All rights reserved.
• Mittel zur Verbesserung des Nachweises Wasserstoffperoxid liefernder Oxidase-Reaktionen und seine Verwendung
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0186134B1

  公开（公告）日：1989-02-15
• Substrate-promoted copper-catalyzed N-arylation of amino alcohols with aryl iodides in water
  作者：Ming Jin、Dan Zhao、Guozhen He、Yao Tong、Shiqing Han

  DOI：10.1016/s1872-2067(12)60623-8

  日期：2013.9

  An efficient method has been developed for the N-arylation of a variety of water-soluble amino alcohols (1.2 mmol) with aryl iodides (1.0 mmol) in water under CuI-catalyzed conditions. The reaction was conducted via substrate-promoted action and did not require an additional ligand or phase-transfer catalyst, and afforded the desired N-aryl amines in acceptable to excellent yields (64%-93%) under mild reaction conditions with a small excess of the amino alcohol. (C) 2013, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.