4,4'-methylenebis[2,6-bis(hydroxymethyl)phenol] | 13653-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-methylenebis[2,6-bis(hydroxymethyl)phenol]
• 英文别名: 3,5,3',5'-tetrahydroxymethyl-4,4'-dihydroxydiphenylmethane；3,3',5,5'-Tetramethylol-4,4'-dihydroxydiphenylmethane；bis-(4-hydroxy-3,5-bis-hydroxymethyl-phenyl)-methane；Bis-(4-hydroxy-3,5-bis-hydroxymethyl-phenyl)-methan；2,6,2',6'-Tetrakis-hydroxymethyl-4,4'-methandiyl-di-phenol；(Methylenebis(2-hydroxybenzene-5,3,1-triyl))tetramethanol；4-[[4-hydroxy-3,5-bis(hydroxymethyl)phenyl]methyl]-2,6-bis(hydroxymethyl)phenol
• CAS: 13653-12-8
• 化学式: C₁₇H₂₀O₆
• 分子量: 320.342
• InChiKey: MWPXMEJTTYFHGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  121
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4,4'-methylenebis[2,6-bis(hydroxymethyl)phenol] 在 盐酸 、 sodium hydroxide 、 palladium on activated charcoal 作用下， 生成 bis-(4-hydroxy-3,5-disalicyl-phenyl)-methane
  参考文献：
  名称：

  Davis et al., Journal of Applied Chemistry, 1957, vol. 7, p. 521,525

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 、 4,4'-二羟基二苯甲烷 在 sodium hydroxide 作用下， 反应 7.0h， 以78%的产率得到4,4'-methylenebis[2,6-bis(hydroxymethyl)phenol]
  参考文献：
  名称：

  利用甲氧基的空间效应，通过分子内[2 + 2]光环加成立体选择性合成间桥和三桥环烷

  摘要：

  通过[2 + 2]光环加成法以61 – 87％的产率立体选择性地获得了二甲氧基[n.2]甲基环环烷9（n = 2、3、4、5和6）和10。当n ＝ 3-6时，它们的构象不包括顺式，而二甲氧基[2.2]间环phane以顺式和反式异构体的比例为4：3的混合物形式存在。减少桦木含量后，成功地以59 – 94％的收率获得了[n.4]个亚甲基环烷11（n = 2-6）。当n ＝ 2-4为反或n ＝ 5且6为syn时，它们的构象。二羟基[n.4]甲基环已烷16（n = 2-6）和二羟基[n.2]甲基环已烷17（n = 4、5和6）的收率分别为93-100 ％和78-95 ％甲氧基脱甲基后。的构象图16和17与相应的二甲氧基甲基环环烷相同。与单体酚一样，16和17中酚基的酸度较低。在通过三氟甲磺酸酯18进行烯化和乙烯基化后，在25 ℃下，亚环烷19和21分别立体选择性地得到三桥[n.2.2]（1,3,4）环烷20和22立体产率为65

  DOI：

  10.1016/s0040-4020(01)89568-5

文献信息

• Novolac resin-containing resist underlayer film-forming composition using bisphenol aldehyde
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10017664B2

  公开（公告）日：2018-07-10

  Resist underlayer film-forming composition for forming resist underlayer film with high dry etching resistance, wiggling resistance and exerts good flattening property and embedding property for uneven parts, including resin obtained by reacting organic compound A including aromatic ring and aldehyde B having at least two aromatic hydrocarbon ring groups having phenolic hydroxy group and having structure wherein the aromatic hydrocarbon ring groups are bonded through tertiary carbon atom. The aldehyde B may be compound of Formula (1): The obtained resin may have a unit structure of Formula (2): Ar1 and Ar2 each are C6-40 aryl group. The organic compound A including aromatic ring may be aromatic amine or phenolic hydroxy group-containing compound. The composition may contain further solvent, acid and/or acid generator, or crosslinking agent. Forming resist pattern used for semiconductor production, including forming resist underlayer film by applying the resist underlayer film-forming composition onto semiconductor substrate and baking it.

  用于形成具有高干法蚀刻抗性、抗扭曲性并具有良好的平整性和嵌入性能的抗蚀底层膜形成组合物，包括通过使含有芳香环的有机化合物A和至少具有两个含酚羟基的芳香烃环团的醛B反应而获得的树脂，并具有芳香烃环团通过三级碳原子键合的结构。醛B可以是化合物的化学式（1）： 所得的树脂可能具有化学式（2）的单元结构： Ar1和Ar2各自是C6-40芳基团。含有芳香环的有机化合物A可能是芳香胺或含酚羟基的化合物。该组合物可能进一步含有溶剂、酸和/或酸发生剂，或交联剂。用于半导体生产的形成抗蚀图案，包括通过将抗蚀底层膜形成组合物涂覆在半导体衬底上并对其进行烘烤来形成抗蚀底层膜。
• [EN] MULTI-FUNCTIONAL ACRYLATES<br/>[FR] ACRYLATES MULTIFONCTIONNELS
  申请人：EMPIRE TECHNOLOGY DEV LLC

  公开号：WO2014126625A1

  公开（公告）日：2014-08-21

  Disclosed herein are derivatives of phenolic and melamine compounds, methods of making these derivatives, and methods of using them. The compounds include phenolic and melamine compounds with multi-functional acrylate groups, polyethylene glycol and amino groups. The compounds may be cured to form resins that may be used in a variety of applications, such as paints, hydrogels, polyacrylate super absorbent polymers (SAPs), adhesives, composites, sealants, fillers, fire retardants, crosslinking agents, and the like.

  本文披露了酚类和三聚氰胺化合物的衍生物，以及制备这些衍生物的方法和使用它们的方法。这些化合物包括具有多功能丙烯酸酯基团、聚乙二醇和氨基团的酚类和三聚氰胺化合物。这些化合物可以固化形成树脂，可用于各种应用，如涂料、水凝胶、聚丙烯酸酯超吸水聚合物（SAP）、粘合剂、复合材料、密封剂、填料、阻燃剂、交联剂等。
• Pulsed 2-Dimensional Raman Spectroscopy on Microdroplets
  作者：H. Moritz、G. Schweiger

  DOI：10.1002/(sici)1521-4125(200004)23:4<361::aid-ceat361>3.0.co;2-g

  日期：2000.4

  Raman spectroscopy to determine the average concentration in the liquid phase and concentration distribution in the gas phase surrounding desorbing linear arrays of binary microdroplets. For this study, monodisperse microdroplets consisting of acetylene dissolved in acetone were generated by a modified vibrating orifice aerosol generator (VOAG). The 2-dimensional concentration fields of acetylene desorbed

  在这项研究中，我们使用基于脉冲拉曼光谱的技术来确定液相中的平均浓度和气相中围绕解吸线性二元微滴阵列的浓度分布。在这项研究中，由溶解在丙酮中的乙炔组成的单分散微滴是通过改进的振动孔气溶胶发生器 (VOAG) 产生的。从液滴中解吸的乙炔二维浓度场的空间分辨率约为 40 μm，沿液滴链方向和垂直于液滴链的方向。气相和液相浓度的检测限分别约为 100 ppm 和 1 mmol/l。
• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• A13C NMR study of the methylol derivatives of 2,4?- and 4,4?-dihydroxydiphenylmethanes found in resol phenol-formaldehyde resins
  作者：Thomas H. Fisher、Ping Chao、Cindy G. Upton、Anthony J. Day

  DOI：10.1002/mrc.1089

  日期：2002.11

  A total of 13 of the 16 possible methylol derivatives of 2,4′- and 4,4′-dihydroxydiphenylmethane have been synthesized, isolated, and identified. These compounds are found as intermediates in the cure process of resol phenol–formaldehyde (PF) resins. Analysis of the 13C NMR spectra (in acetone-d6) of these compounds provided a way to evaluate the seven methylolphenol ring types (methylol derivatives of 2-hydroxyphenyl and 4-hydroxyphenyl rings) found in typical resol PF resins using the ipso carbon region from 150 to 160 ppm. A simple diagnostic test was developed using the chemical shift values of the methylol methylene carbon atoms to identify the presence of intermediates containing either a 2-hydroxyphenyl or a 4-hydroxyphenyl ring. Using these data it is now possible to analyze the major components in extracted prepreg PF resins. Copyright © 2002 John Wiley & Sons, Ltd.

  在 2,4′- 和 4,4′- 二羟基二苯基甲烷的 16 种可能的甲醇衍生物中，共合成、分离和鉴定了 13 种。这些化合物是 resol酚-甲醛（PF）树脂固化过程中发现的中间体。通过分析这些化合物的 13C NMR 光谱（丙酮-d6 中），可以利用 150 至 160 ppm 的异碳区评估典型的 resol PF 树脂中的七种甲酚环类型（2-羟基苯基和 4-羟基苯基环的甲醇衍生物）。利用甲醇亚甲基碳原子的化学位移值开发了一种简单的诊断测试方法，以确定是否存在含有 2-羟基苯基或 4-羟基苯基环的中间体。利用这些数据，现在可以分析提取的预浸料 PF 树脂中的主要成分。Copyright © 2002 John Wiley & Sons, Ltd. All Rights Reserved.