6β-(2-methylsulfanyl-acetylamino)-penicillanic acid | 91431-28-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 6β-(2-methylsulfanyl-acetylamino)-penicillanic acid
• 英文别名: 6β-(2-Methylmercapto-acetylamino)-penicillansaeure；(2S,5R,6R)-3,3-dimethyl-6-[(2-methylsulfanylacetyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS: 91431-28-6
• 化学式: C₁₁H₁₆N₂O₄S₂
• 分子量: 304.391
• InChiKey: FAYLZQQSDFHREF-BKPPORCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (甲硫基)乙酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 6β-(2-methylsulfanyl-acetylamino)-penicillanic acid
  参考文献：
  名称：

  Taira et al., Journal of Antibiotics, 1951, vol. 4, p. 347,350

  摘要：

  DOI：

文献信息

• Nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues, and methods of making same using peptide modifying agents
  申请人：——

  公开号：US20030235852A1

  公开（公告）日：2003-12-25

  Libraries of nucleic acid-peptide fusion molecules are provided, wherein the peptide component of the fusion molecules contains one or more unnatural amino acid residues. Methods of making such libraries using one or more peptide modifying agents also are provided, as are methods of screening such libraries to identify peptides having desirable characteristics. Accordingly, isolated nucleic acid-peptide molecules also are provided, wherein the peptide component has a desirable characteristic, and is composed partially or entirely of unnatural amino acid residues.

  提供了核酸-肽融合分子文库，其中融合分子的肽成分含有一个或多个非天然氨基酸残基。还提供了使用一种或多种肽修饰剂制造这种文库的方法，以及筛选这种文库以鉴定具有理想特性的肽的方法。因此，还提供了分离的核酸-肽分子，其中的肽成分具有理想的特性，并且部分或全部由非天然氨基酸残基组成。
• Behrens et al., Journal of Biological Chemistry, 1948, vol. 175, p. 801
  作者：Behrens et al.

  DOI：——

  日期：——
• NUCLEIC ACID-PEPTIDE DISPLAY LIBRARIES CONTAINING PEPTIDES WITH UNNATURAL AMINO ACID RESIDUES, AND METHODS OF MAKING SAME
  申请人：California Institute of Technology

  公开号：EP1504111A2

  公开（公告）日：2005-02-09
• EP1504111A4
  申请人：——

  公开号：EP1504111A4

  公开（公告）日：2005-11-23
• Methods of using sense and/or nonsense suppression to make nucleic acid-peptide display libraries containing peptides with unnatural amino acid residues
  申请人：——

  公开号：US20030235851A1

  公开（公告）日：2003-12-25

  Libraries of nucleic acid-peptide fusion molecules are provided, wherein the peptide component of the fusion molecules contains one or more unnatural amino acid residues. Methods of making such libraries using sense suppression and/or nonsense suppression also are provided, as are methods of screening such libraries to identify peptides having desirable characteristics. Accordingly, isolated nucleic acid-peptide molecules also are provided, wherein the peptide component has a desirable characteristic, and is composed partially or entirely of unnatural amino acid residues.