9H-fluoren-9-ylmethyl 4-(4-bromophenyl)-4-carbonochloridoylpiperidine-1-carboxylate | 913542-82-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl 4-(4-bromophenyl)-4-carbonochloridoylpiperidine-1-carboxylate
• CAS: 913542-82-2
• 化学式: C₂₇H₂₃BrClNO₃
• 分子量: 524.842
• InChiKey: OCJHZCFXCOYTBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9H-fluoren-9-ylmethyl 4-(4-bromophenyl)-4-carbonochloridoylpiperidine-1-carboxylate 、 4-甲氧基苄胺 、 4-咪唑甲醛 、 2-氟-3-甲氧基苯硼酸 生成 4-[4-(2-fluoro-3-methoxyphenyl)phenyl]-1-(1H-imidazol-5-ylmethyl)-N-[(4-methoxyphenyl)methyl]piperidine-4-carboxamide
  参考文献：
  名称：

  Solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides

  摘要：

  A novel solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides has been developed using FDMP resin with a carboxamide as the anchor point. With this approach, three points of diversity were incorporated into a GPCR-directed scaffold. Final products were obtained in good purity and yield. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.06.070
• 作为产物：
  描述：

  4-(4-溴苯基)-4-氰基哌啶-1-羧酸叔丁酯 在 草酰氯 、 硫酸 、 水 、 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 生成 9H-fluoren-9-ylmethyl 4-(4-bromophenyl)-4-carbonochloridoylpiperidine-1-carboxylate
  参考文献：
  名称：

  Solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides

  摘要：

  A novel solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides has been developed using FDMP resin with a carboxamide as the anchor point. With this approach, three points of diversity were incorporated into a GPCR-directed scaffold. Final products were obtained in good purity and yield. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.06.070

文献信息

• Solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides
  作者：Jin Zhu、Richard S. Pottorf、Mark R. Player

  DOI：10.1016/j.tetlet.2006.06.070

  日期：2006.10

  A novel solid-phase synthesis of 4-biaryl-piperidine-4-carboxamides has been developed using FDMP resin with a carboxamide as the anchor point. With this approach, three points of diversity were incorporated into a GPCR-directed scaffold. Final products were obtained in good purity and yield. (c) 2006 Published by Elsevier Ltd.