(6,8-Dibromo-5-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol | 217435-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: (6,8-Dibromo-5-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol
• 英文别名: (6,8-Dibromo-5-methylimidazo[1,2-a]pyridin-3-yl)methanol
• CAS: 217435-72-8
• 化学式: C₉H₈Br₂N₂O
• 分子量: 319.983
• InChiKey: GVTIKDITKQTSFZ-UHFFFAOYSA-N

物化性质

• 密度：
  2.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-噻吩甲基硫醇 、 (6,8-Dibromo-5-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol 在 溶剂黄146 作用下， 以69%的产率得到6,8-Dibromo-5-methyl-3-(thiophen-2-ylmethylsulfanylmethyl)-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Mavel; Renou; Galtier, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 4, p. 304 - 309

  摘要：

  DOI：
• 作为产物：
  描述：

  紫藤提取物 在 sodium acetate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 (6,8-Dibromo-5-methyl-imidazo[1,2-a]pyridin-3-yl)-methanol
  参考文献：
  名称：

  Synthesis of Imidazo[1,2-a]pyridines as Antiviral Agents

  摘要：

  The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

  DOI：

  10.1021/jm981051y

文献信息

• Synthesis of Imidazo[1,2-<i>a</i>]pyridines as Antiviral Agents
  作者：Alain Gueiffier、Sylvie Mavel、Mohammed Lhassani、Ahmed Elhakmaoui、Robert Snoeck、Graciela Andrei、Olivier Chavignon、Jean-Claude Teulade、Myriam Witvrouw、Jan Balzarini、Erik De Clercq、Jean-Pierre Chapat

  DOI：10.1021/jm981051y

  日期：1998.12.1

  The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.
• Mavel; Renou; Galtier, Arzneimittel-Forschung/Drug Research, 2001, vol. 51, # 4, p. 304 - 309
  作者：Mavel、Renou、Galtier、Snoeck、Andrei、Balzarini、De Clercq、Gueiffier

  DOI：——

  日期：——