9-phenyl-xanthene-9-carboxylic acid | 204981-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 9-phenyl-xanthene-9-carboxylic acid
• 英文别名: 9-Phenyl-xanthen-9-carbonsaeure；9-Phenylxanthene-9-carboxylic acid
• CAS: 204981-66-8
• 化学式: C₂₀H₁₄O₃
• 分子量: 302.329
• InChiKey: NZGIDDYYPHOMPI-UHFFFAOYSA-N

物化性质

• 沸点：
  473.3±45.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9-phenyl-xanthene-9-carboxylic acid 、 N,N-二乙基氯乙胺 在 异丙醇 作用下， 生成 9-phenyl-xanthene-9-carboxylic acid-(2-diethylamino-ethyl ester); hydrochloride
  参考文献：
  名称：

  Iwashige; Takagi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 614,616

  摘要：

  DOI：
• 作为产物：
  描述：

  苯基溴化镁 在 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 2.25h， 生成 9-phenyl-xanthene-9-carboxylic acid
  参考文献：
  名称：

  Triarylmethanes and 9-arylxanthenes as prototypes amphihydric compounds for relating the stabilities of cations, anions and radicals by C-H bond cleavage and electron transfer

  摘要：

  Thermodynamic stability properties of II p-substituted trityl and seven 9-phenylxanthyl carbocations are reported in sulfolane and of their conjugate carbanions in DMSO. The cations are compared by calorimetric heats of hydride transfer from cyanoborohydride ion, their first and second reduction potentials, their PK(R)(+)s in aqueous sulfuric acid, C-13 chemical shifts and free energies of methoxy exchange. Carbanlons are compared by their heats and free energies (pK(HA)) of deprotonation and their first and second oxidation potentials. Radicals are compared by their oxidation and reduction potentials. Their bond dissociation energies are derived by alternative routes: from the carbocation and its reduction potential and from the carbanion and its oxidation potential. The various properties are correlated against each other and against appropriate Hammett-type substituent parameters. Correlations between the different measured properties reported here range from fair to excellent, Despite their importance as historic prototypes for the three trivalent oxidation states of carbon, trityl and xanthyl systems are atypical models for comparing transmission of electron demand In other series of carbocations, radicals or carbanions with significantly different structures. The 9-arylxanthyl series is especially poor because of its insensitivity to substituent effects. The effects of substituents on various properties which represent the stabilities of R(+)s correlate surprisingly well against those for corresponding R(-)s. Accordingly, compensating effects on the oxidation and reduction of a series of related RS may lead to a nearly constant electron transfer energy and absolute hardness for the series. In contrast, the free energies for interconversion of the carbocations and carbanions which determine the gap between pK(R+) and pK(HA) are very sensitive to structural change. (C) 1997 by John Wiley & Sons, Ltd.

  DOI：

  10.1002/(sici)1099-1395(199707)10:7<499::aid-poc896>3.0.co;2-2

文献信息

• Fluorescence screening for blood typing
  申请人：SYVA COMPANY

  公开号：EP0106685A2

  公开（公告）日：1984-04-25

  A sensitive method for identifying red blood cell antigens or antibodies thereto is provided. A fluorescent bead is conjugated to a receptor specific for a red blood cell antigen (ligand) or alternatively with an antigen for determination of antibodies. The conjugate is mixed with a red blood cell containing composition. A change in fluorescence compared with a control reveals the presence or absence of the antigen or antibody.

  提供了一种鉴定红细胞抗原或其抗体的灵敏方法。荧光珠与红细胞抗原（配体）的特异性受体共轭，或与用于测定抗体的抗原共轭。缀合物与含有红细胞的组合物混合。与对照组相比，荧光的变化可显示抗原或抗体的存在与否。
• Method and apparatus for enhanced detection of electromagnetic signals
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0155813A2

  公开（公告）日：1985-09-25

  A beam of incident electromagnetic radiation is generated having a spatial distribution of intensity periodically varying in time. A receiver suspected of containing an analyte is irradiated with the beam, and the electromagnetic signal emitted is detected and the correlation, if any, is determined between the periodicity of the applied beam and fluctuations in the detected signal. The method and apparatus have particular applicability in the field of particle detection, e.g. fluorescent particle detection.

  产生一束入射电磁辐射，其强度的空间分布随时间周期性变化。用该光束照射疑似含有分析物的接收器，检测发射的电磁信号，并确定施加光束的周期性与检测信号波动之间的相关性（如有）。该方法和装置特别适用于粒子检测领域，例如荧光粒子检测。
• Fluid handling apparatus and method
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0190019A2

  公开（公告）日：1986-08-06

  A fluid handling system is described wherein a small fluid volume (16) is placed on a reversibly-deformable support (12), which can be deformed to form a cavity. As the fluid clings to the surface of the support, it is physically agitated and mixed as the support is deformed. The deformable support can be utilized to provide fluid containers of varying sizes, to accommodate different fluid volumes and as a transport mechanism to move fluid from one location to another.

  描述了一种流体处理系统，在该系统中，小体积流体（16）被放置在可逆变形支架（12）上，支架可变形以形成空腔。当流体附着在支架表面时，会随着支架的变形而受到物理搅拌和混合。可变形支架可用于提供不同大小的流体容器，以容纳不同体积的流体，也可用作将流体从一个位置移动到另一个位置的运输装置。
• Apparatus and method for detection of fluorescence or light scatter
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0335725A2

  公开（公告）日：1989-10-04

  An apparatus and method are described for defining a small interrogation volume in a liquid sample suspected of containing an analyte. The apparatus and method utilize a dual optical fibre probe (10) constructed with the ends of the optical fibres (12,14) at the liquid/fibre interface spatially oriented such that the intersection of their longitudinal axes forms an included angle ranging from about 40° to 140°. By appropriate choice of the numerical aperture and core diameter of the optical fibres and the separation distance between the longitudinal axes of the optical fibres at the liquid/fibre interface, a finite interrogation volume of predetermined size and independent of the total liquid sample volume can be defined. The apparatus and method substantially reduce background interference with corresponding increase in assay sensitivity.

  该仪器和方法用于在疑似含有分析物的液体样品中确定一个小的探测体积。该仪器和方法利用双光纤探头（10），其位于液体/光纤界面的光纤（12,14）两端在空间上定向，使其纵轴的交点形成一个约 40° 至 140° 的包含角。通过适当选择光导纤维的数值孔径和纤芯直径以及液体/纤维界面处光导纤维纵轴之间的分离距离，可以确定一个预定大小且与液体样品总体积无关的有限探测体积。该仪器和方法大大减少了背景干扰，并相应提高了检测灵敏度。
• Akagi; Iwashige, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 610,613
  作者：Akagi、Iwashige

  DOI：——

  日期：——