1-(3,5-Dimethoxyphenyl)-2-phenyl-2-oxoethylphosphate | 131376-66-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(3,5-Dimethoxyphenyl)-2-phenyl-2-oxoethylphosphate
• 英文别名: 1-(3,5-Dimethoxyphenyl)-2-oxo-2-phenylethyl dihydrogen phosphate；[1-(3,5-Dimethoxyphenyl)-2-oxo-2-phenylethyl] dihydrogen phosphate
• CAS: 131376-66-4
• 化学式: C₁₆H₁₇O₇P
• 分子量: 352.281
• InChiKey: UTGFVAIODGEOTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-(3,5-Dimethoxyphenyl)-2-phenyl-2-oxoethylphosphate 以 水 为溶剂， 生成 2-Phenyl-5,7-dimethoxybenzofuran 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Corrie, John E. T.; Trentham, David R., Journal of the Chemical Society. Perkin transactions I, 1992, # 18, p. 2409 - 2418

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-dimethoxybenzoin 在 四氮唑 、 盐酸 、 sodium hydroxide 、 对甲苯磺酸 、 间氯过氧苯甲酸 作用下， 以 水 、 苯 为溶剂， 反应 20.0h， 生成 1-(3,5-Dimethoxyphenyl)-2-phenyl-2-oxoethylphosphate
  参考文献：
  名称：

  Corrie, John E. T.; Trentham, David R., Journal of the Chemical Society. Perkin transactions I, 1992, # 18, p. 2409 - 2418

  摘要：

  DOI：

文献信息

• New photolabile phosphate protecting group
  作者：Jack E. Baldwin、Adrian W. McConnaughie、Mark G. Moloney、Andrew J. Pratt、Sung Bo Shin

  DOI：10.1016/s0040-4020(01)87875-3

  日期：1990.1

  The synthesis of phosphate, protected with various photolabile protecting groups, is described. Upon laser photolysis at 355 nm, inorganic phosphate is released, in yields of up to 85%.

  描述了用各种光不稳定保护基保护的磷酸酯的合成。在355 nm处进行激光光解后，会释放出无机磷酸盐，产率最高可达85％。
• SYSTEMS AND DEVICES FOR PHOTOABLATION
  申请人：Cardiac Pacemakers, Inc.

  公开号：EP2188014A1

  公开（公告）日：2010-05-26
• Systems and devices for photoablation
  申请人：Stolen Craig

  公开号：US20090054883A1

  公开（公告）日：2009-02-26

  The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and/or one or more selected wavelengths of light.
• US8480662B2
  申请人：——

  公开号：US8480662B2

  公开（公告）日：2013-07-09
• [EN] SYSTEMS AND DEVICES FOR PHOTOABLATION<br/>[FR] SYSTÈMES ET DISPOSITIFS DE PHOTO-ABLATION
  申请人：CARDIAC PACEMAKERS INC

  公开号：WO2009025826A1

  公开（公告）日：2009-02-26

  The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, which in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system including the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and/or one or more selected wavelengths of light.