2-Diphenylmethyl-benzylalkohol | 6624-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-Diphenylmethyl-benzylalkohol
• 英文别名: [2-(Diphenylmethyl)phenyl]methanol；(2-benzhydrylphenyl)methanol
• CAS: 6624-01-7
• 化学式: C₂₀H₁₈O
• 分子量: 274.362
• InChiKey: DPRRPKOYCAUSRR-UHFFFAOYSA-N

物化性质

• 沸点：
  414.5±14.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Diphenylmethyl-benzylalkohol 在 吡啶 、 氯化亚砜 、 magnesium 作用下， 生成 (2-methylphenyl)diphenylmethane
  参考文献：
  名称：

  627.氢转移。第十五部分。2-二苯基甲基苯乙烯的合成与环脱氢

  摘要：

  DOI：

  10.1039/jr9600003144
• 作为产物：
  描述：

  苯酞 在 萘 、 磷酸 、 水 、 lithium 作用下， 以 四氢呋喃 、 乙醚 、 水 为溶剂， 反应 17.0h， 生成 2-Diphenylmethyl-benzylalkohol
  参考文献：
  名称：

  Electron-Transfer-Induced Reductive Cleavage of Phthalans:  Reactivity and Synthetic Applications

  摘要：

  The behavior of phthalan (1a) was investigated under conditions of electron transfer from alkali metals in aprotic solvents. Reaction with lithium in the presence of a catalytic amount of naphthalene in THF led to the reductive cleavage of an arylmethyl carbon-oxygen bond, with formation of a stable dilithium compound. Trapping of this intermediate with several electrophiles (alkyl halides, carbonyl derivatives, CO2) was successful. The extension of this procedure to several substituted phthalans (1b-i) was investigated, and the regiochemistry as well as the synthetic usefulness of these reactions are discussed.

  DOI：

  10.1021/jo9604548

文献信息

• Reactions of 2-Benzhydrylphenylacetic Acid; A New Pyrone Synthesis¹
  作者：R. L. LETSINGER、J. D. JAMISON、A. S. HUSSEY

  DOI：10.1021/jo01060a023

  日期：1961.1
• SCHULTZ; SCHNEKENBURGER, Archiv der Pharmazie, 1960, vol. 293 /65, p. 678 - 682
  作者：SCHULTZ、SCHNEKENBURGER

  DOI：——

  日期：——
• Electron-Transfer-Induced Reductive Cleavage of Phthalans:  Reactivity and Synthetic Applications
  作者：Ugo Azzena、Salvatore Demartis、Giovanni Melloni

  DOI：10.1021/jo9604548

  日期：1996.1.1

  The behavior of phthalan (1a) was investigated under conditions of electron transfer from alkali metals in aprotic solvents. Reaction with lithium in the presence of a catalytic amount of naphthalene in THF led to the reductive cleavage of an arylmethyl carbon-oxygen bond, with formation of a stable dilithium compound. Trapping of this intermediate with several electrophiles (alkyl halides, carbonyl derivatives, CO2) was successful. The extension of this procedure to several substituted phthalans (1b-i) was investigated, and the regiochemistry as well as the synthetic usefulness of these reactions are discussed.
• 627. Hydrogen transfer. Part XV. The synthesis and cyclodehydrogenation of 2-diphenylmethylstyrene
  作者：R. F. Brown、L. M. Jackman

  DOI：10.1039/jr9600003144

  日期：——