N,N'-di-n-butylphthalamide | 19532-96-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-di-n-butylphthalamide
• 英文别名: N,N'-dibutylphthalamide；N,N'-Dibutyl-phthalsaeure-diamid；1-N,2-N-dibutylbenzene-1,2-dicarboxamide
• CAS: 19532-96-8
• 化学式: C₁₆H₂₄N₂O₂
• 分子量: 276.379
• InChiKey: CALJQXBUHJNONT-UHFFFAOYSA-N

物化性质

• 熔点：
  103-104 °C
• 沸点：
  494.0±28.0 °C(Predicted)
• 密度：
  1.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-di-n-butylphthalamide 生成 正丁胺
  参考文献：
  名称：

  GANIN, EH. V.;NIKITIN, V. I.;ANIKIN, V. F.;KAMALOV, G. L., YKP. XIM. ZH., 1982, 48, N 9, 988-991

  摘要：

  DOI：
• 作为产物：
  描述：

  1-acetoxy-2-phthalimidoethyl methyl sulphide 在 四氯化锡 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 N,N'-di-n-butylphthalamide
  参考文献：
  名称：

  McCormick, Joan E.; McElbinney, R. Stanley, Journal of Chemical Research, Miniprint, 1981, # 10, p. 3601 - 3641

  摘要：

  DOI：

文献信息

• [EN] MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS<br/>[FR] COMPLEXES À BASE DE MANGANÈSE ET LEURS UTILISATIONS SERVANT À UNE CATALYSE HOMOGÈNE
  申请人：YEDA RES & DEV

  公开号：WO2017137984A1

  公开（公告）日：2017-08-17

  The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

  本发明涉及新型锰配合物及其用途，包括但不限于在以下领域进行均相催化：（1）通过醇和胺的脱氢偶联制备亚胺；（2）使用腈作为迈克尔供体进行迈克尔加成反应中的C-C偶联；（3）将醇脱氢偶联以得到酯和氢气；（4）将酯加氢以形成醇（包括环酯（内酯）或环二酯（二内酯）或聚酯的加氢）；（5）将酰胺（包括环二肽、内酰胺、二酰胺、多肽和聚酰胺）加氢以得到醇和胺（或二胺）；（6）将有机碳酸酯（包括聚碳酸酯）加氢以得到醇或将氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物加氢以得到醇和胺；（7）将二级醇脱氢以得到酮；（8）酯的酰胺化（即从酯和胺合成酰胺）；（9）使用酯对醇进行酰化；（10）将醇与水和碱偶联以形成羧酸；以及（11）通过氨基醇与水和碱的偶联制备氨基酸或其盐。（12）通过醇和胺的脱氢偶联制备酰胺（包括甲酰胺、环二肽、二酰胺、内酰胺、多肽和聚酰胺）；（13）从二醇制备酰亚胺。
• SYNTHÈSES D'ACIDES AMINOBUTYRIQUES. 1. ACIDES ALKYLAMINO-2 AMINO-4 BUTYRIQUES
  作者：Réal Laliberté、Louis Berlinguet

  DOI：10.1139/v60-260

  日期：1960.10.1

  The syntheses of eight 2-alkylamino-4-aminobutyric acids are described. The starting material is 4-butyrolactone, which is opened with potassium phthalimide to give 4-phthalimidobutyric acid. After bromination the 2-bromo-4-phthalimidobutyric acid, obtained in excellent yield, is treated with aliphatic amines in alcoholic medium to give the desired substituted 2,4-diaminobutyric acids, which were characterized as the monohydrochlorides and the di(phenylcarbamates). Three of them cyclized easily to give the corresponding hydantoins. In the course of the reaction, substituted diamides of phthalic acid were isolated and characterized.

  本文介绍了合成八种2-烷基氨基-4-氨基丁酸的方法。起始材料为4-丁酰内酯，它与邻苯二甲酰亚胺钾开环，形成4-邻苯二甲酰亚胺丁酸。溴化后，得到优良产率的2-溴-4-邻苯二甲酰亚胺丁酸，然后在醇介质中与脂肪胺反应，制得所需的取代2,4-二氨基丁酸，其作为单一盐酸盐和二苯基氨基甲酸酯被表征。其中三种很容易环化成相应的咪唑二酮。在反应过程中，分离并表征了邻苯二甲酸的取代二酰胺。
• Ranadive, V. B.; Khadilkar, B. M.; Samant, S. D., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, p. 1175 - 1177
  作者：Ranadive, V. B.、Khadilkar, B. M.、Samant, S. D.

  DOI：——

  日期：——
• Peculiarities of the reaction of N,N?-substituted diphthalimides with amines
  作者：V. F. Anikin、�. V. Ganin、B. V. Rozynov、R. M. Zakharova、G. L. Kamalov

  DOI：10.1007/bf00512968

  日期：1982.2
• Ganin, E. V.; Makarov, V. F.; Rozynov, B. V., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 9, p. 1772 - 1777
  作者：Ganin, E. V.、Makarov, V. F.、Rozynov, B. V.

  DOI：——

  日期：——