3'-amino-2,5',10'-trioxo-5',10'-dihydro-2H-spiro[acenaphthylene-1,1'-pyrazolo[1,2-b]phthalazine]-2'-carbonitrile | 1395095-06-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3'-amino-2,5',10'-trioxo-5',10'-dihydro-2H-spiro[acenaphthylene-1,1'-pyrazolo[1,2-b]phthalazine]-2'-carbonitrile
• 英文别名: 1'-Amino-2,5',10'-trioxospiro[acenaphthylene-1,3'-pyrazolo[1,2-b]phthalazine]-2'-carbonitrile；1'-amino-2,5',10'-trioxospiro[acenaphthylene-1,3'-pyrazolo[1,2-b]phthalazine]-2'-carbonitrile
• CAS: 1395095-06-3
• 化学式: C₂₃H₁₂N₄O₃
• 分子量: 392.373
• InChiKey: PVBXOGAUXRGDBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  邻苯二甲酰肼 、 丙二腈 、 苊醌 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以96%的产率得到3'-amino-2,5',10'-trioxo-5',10'-dihydro-2H-spiro[acenaphthylene-1,1'-pyrazolo[1,2-b]phthalazine]-2'-carbonitrile
  参考文献：
  名称：

  An efficient ultrasound-promoted one pot synthesis of spiroacenaphthylene pyrazolotriazole and pyrazolophthalazine derivatives

  摘要：

  A facile and efficient one pot three-component ultrasound-promoted synthesis of spiro pyrazolo compounds has been developed. Employing ethanol as a solvent, assumed to be relatively environmentally benign, and use of an inexpensive and readily available catalyst combined with the advantages of sono-chemistry, such as mild reaction conditions, excellent yield, and short reaction times highlight this synthetic route. The reactions were carried out under both conventional heating and ultrasound-assisted conditions and several reaction parameters are investigated and compared. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.049

文献信息

• An efficient ultrasound-promoted one pot synthesis of spiroacenaphthylene pyrazolotriazole and pyrazolophthalazine derivatives
  作者：Seyed Jamal Tabatabaei Rezaei、Yasamin Bide、Mohammad Reza Nabid

  DOI：10.1016/j.tetlet.2012.07.049

  日期：2012.9

  A facile and efficient one pot three-component ultrasound-promoted synthesis of spiro pyrazolo compounds has been developed. Employing ethanol as a solvent, assumed to be relatively environmentally benign, and use of an inexpensive and readily available catalyst combined with the advantages of sono-chemistry, such as mild reaction conditions, excellent yield, and short reaction times highlight this synthetic route. The reactions were carried out under both conventional heating and ultrasound-assisted conditions and several reaction parameters are investigated and compared. (C) 2012 Elsevier Ltd. All rights reserved.