(3-methyloxazolidin-2-ylidene)-(phenyl)-amine | 2933-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-methyloxazolidin-2-ylidene)-(phenyl)-amine
• 英文别名: 2-phenylimino-N-methyl-oxazolidine；(3-methyl-oxazolidin-2-ylidene)-phenyl-amine；3-Methyl-2-phenylimino-2,3,4,5-tetrahydro-oxazol；2-Phenylimino-3-methyl-1,3-oxazolidin；3-Methyl-2-phenylimino-2-oxazolin；3-Methyl-2-phenylimino-oxazolidin；N-(3-methyl-1,3-oxazolidin-2-ylidene)aniline；3-methyl-N-phenyl-1,3-oxazolidin-2-imine
• CAS: 2933-49-5
• 化学式: C₁₀H₁₂N₂O
• 分子量: 176.218
• InChiKey: BVOCRNXSHAYCCX-UHFFFAOYSA-N

物化性质

• 熔点：
  74 °C
• 沸点：
  132-135 °C(Press: 0.2 Torr)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  24.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-2-Hydroxyaethyl-N-methyl-N',N''-diphenylguanidin 以 xylene 为溶剂， 生成 (3-methyloxazolidin-2-ylidene)-(phenyl)-amine
  参考文献：
  名称：

  1014. 2-氨基-2-咪唑啉和2-氨基-2-恶唑啉

  摘要：

  DOI：

  10.1039/jr9610005120

文献信息

• A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH
  作者：Uwe Heinelt、Daniela Schultheis、Siegfried Jäger、Marion Lindenmaier、Annett Pollex、Henning S.g. Beckmann

  DOI：10.1016/j.tet.2004.08.031

  日期：2004.10

  p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis. (C) 2004 Elsevier Ltd. All rights reserved.
• Dousse, G.; Lavayssiere, H.; Satge, J., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1989, vol. 19, p. 49 - 74
  作者：Dousse, G.、Lavayssiere, H.、Satge, J.

  DOI：——

  日期：——
• 1014. 2-Amino-2-imidazolines and 2-amino-2-oxazolines
  作者：B. Adcock、Alexander Lawson、D. H. Miles

  DOI：10.1039/jr9610005120

  日期：——