[Ag₂(9-aca)₂]

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: [Ag₂(9-aca)₂]
• 英文别名: [Ag2(9-aca)2]n；[Ag2(9-anthracenecarboxylate)2]n；[(silver(I))2(9-anthracenecaroxylate)2]；Silver;anthracene-9-carboxylate
• 化学式: 2Ag*2C₁₅H₉O₂
• 分子量: 658.207
• InChiKey: ZBQBIUBKFILKSU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-丁基咪唑 、 [Ag₂(9-aca)₂] 以 乙腈 为溶剂， 以51%的产率得到[((silver(I)(1-butylimidazole)2)2((silver(I))4(9-antracenecarboxylate)6)]
  参考文献：
  名称：

  Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity

  摘要：

  [Ag2(9-aca)2] (1) (9-acaH = 9-蒽甲酸) 与一系列咪唑化合物反应生成 [Ag(imidH)2.3(CH3CN)0.7](9-aca) (3)，[Ag6(imidH)4(9-aca)6(MeOH)2] (4)，{[Ag(1-Me-imid)2]2[Ag4(9-aca)6]} (5)，{[Ag(1-Bu-imid)2]2[Ag4(9-aca)6]} (6) 和 [Ag(apim)](9-aca)·H2O (7) (imidH = 咪唑；1-Me-imid = 1-甲基咪唑；1-Bu-imid = 1-丁基咪唑；apim = 1-(3-氨基丙基)咪唑)。单核复合物 3、六核复合物 4–6 和聚合物 7 均通过 X 射线晶体学进行表征。虽然许多复合物具有良好的体外抗真菌和抗菌活性，但它们一致地对真菌细胞更有效。昆虫大蠊 (Galleria mellonella) 能够承受高剂量的 Ag(I) 复合物的体内给药，且多种复合物对感染致死性病原性白色念珠菌细胞的幼虫提供显著保护。

  DOI：

  10.1039/c2dt12166b
• 作为产物：
  描述：

  9-蒽甲酸 、 silver(l) oxide 以 乙醇 为溶剂， 以21%的产率得到[Ag₂(9-aca)₂]
  参考文献：
  名称：

  [Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH=9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities

  摘要：

  [Ag-2(9-aca)(2)](n) and [Ag-4(9-aca)(4)(NH3)(2)] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag-2(9-aca)(2)](n), consists of polymeric ribbons of linked disilver(I) syn-syn bridged dicarboxylate units. [Ag-4(9-aca)(4)(NH3)(2)] is tetrameric and centrosymmetric, with two syn-syn bridging carboxylates linked to the bimetallic Ag-Ag core and a further two syn-anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2007.06.021

文献信息

• Wolcan; Torchia; Tocho, Journal of the Chemical Society. Dalton Transactions (2001), 2002, # 10, p. 2194 - 2202
  作者：Wolcan、Torchia、Tocho、Piro、Juliarena、Ruiz、Feliz

  DOI：——

  日期：——
• Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles
  作者：Malachy McCann、Robert Curran、Marcia Ben-Shoshan、Vickie McKee、Michael Devereux、Kevin Kavanagh、Andrew Kellett

  DOI：10.1016/j.poly.2013.03.057

  日期：2013.6

  [Ag-2(9-aca)(2)] (9-acaH = 9-anthracenecarboxylic acid) interacts with DMSO and a selection of substituted imidazoles giving [Ag-4(DMSO)(4)(9-aca)(4)] (1), [Ag(2-Me-imH)(2)(9-aca)] (2), [Ag(4-Ph-imH)(2)(9-aca)] (3), [Ag(2-Mebenz-imH)2(()9-aca)] (4), [Ag(2-Mebenz-im)] (6), [Ag(Benz-im)] (7), [Ag(2-Ph-im)] (8) and [Ag(4,5-CN-im)] (9) (2-Me-imH = 2-methylimidazole; 4-Ph-imH = 4-phenylimidazole; 2-Mebenz-imH = 2-methylbenzimidazole; Benz-imH = benzimidazole; 2-Ph-imH = 2-phenylbenzimidazole; 4,5-CN-imH = 4,5-dicyanoimidazole). In the carboxylate/imidazole complexes 2-4, the imidazole ligand is in the neutral form, whilst in complexes 6-9 the imidazolate ligand is deprotonated and no carboxylate ligand is present. Attempted recrystallization of 4 from EtOH gives the metal-free, imidazolium salt, 2-Mebenz-imH(2))(9-aca)center dot H2O (5). The X-ray crystal structures of complexes 1 and 2 and the salt 5 were determined. Antimicrobial screening showed that the Ag(l) complexes were substantially more active against the fungus Candida albicans than the bacterial species, methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Some of the complexes offer a good prognosis for Galleria mellonella (larvae of the greater wax moth) infected with a lethal dose of C. albicans cells. (C) 2013 Elsevier Ltd. All rights reserved.
• NEUGEBAUER, W.;CLARK, T.;SCHLEYER, P. R., CHEM. BER., 1983, 116, N 10, 3283-3292
  作者：NEUGEBAUER, W.、CLARK, T.、SCHLEYER, P. R.

  DOI：——

  日期：——
• US4174447A
  申请人：——

  公开号：US4174447A

  公开（公告）日：1979-11-13
• US4188274A
  申请人：——

  公开号：US4188274A

  公开（公告）日：1980-02-12