Ethyl 2-[(2,3-dichlorophenyl)-[(2-methylpropan-2-yl)oxycarbonyloxy]methyl]prop-2-enoate | 1065642-75-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-[(2,3-dichlorophenyl)-[(2-methylpropan-2-yl)oxycarbonyloxy]methyl]prop-2-enoate
• 英文别名: ethyl 2-[(2,3-dichlorophenyl)-[(2-methylpropan-2-yl)oxycarbonyloxy]methyl]prop-2-enoate
• CAS: 1065642-75-2
• 化学式: C₁₇H₂₀Cl₂O₅
• 分子量: 375.249
• InChiKey: VBLVCMRXPGMICL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl 2-[(2,3-dichlorophenyl)-[(2-methylpropan-2-yl)oxycarbonyloxy]methyl]prop-2-enoate 、 N-亚苄基-4-甲基苯磺酰胺 在 三苯基膦 作用下， 以 甲苯 为溶剂， 以63%的产率得到
  参考文献：
  名称：

  A Phosphine-Catalyzed [3 + 2] Annulation Reaction of Modified Allylic Compounds and N-Tosylimines

  摘要：

  A phosphine-catalyzed annulation of modified allylic ylides with various aromatic imines to form 3-pyrrolines was developed. The presence of a substituent in the allylic compound is crucial for this reaction. Without the substituent, (E)-dienylimines will be produced via the dimerization of the allylic compounds.

  DOI：

  10.1021/ol801661y

文献信息

• Enantioselective synthesis of spirocyclic cyclopentenes: asymmetric [3+2] annulation of 2-arylideneindane-1,3-diones with MBH carbonates derivatives catalyzed by multifunctional thiourea–phosphines
  作者：Fangle Hu、Yin Wei、Min Shi

  DOI：10.1016/j.tet.2012.07.013

  日期：2012.9

  The [3+2] annulation reactions of 2-arylideneindane-1,3-diones with Morita–Baylis–Hillman (MBH) carbonates proceeded smoothly in the presence of multifunctional thiourea–phosphines to produce the corresponding quaternary carbon centered spirocyclic cyclopentenes in moderate yields, with high diastereoselectivities and enantioselectivities under mild conditions. The plausible reaction has been also

  在多功能硫脲-膦的存在下，2-芳基亚乙基-1,3-二酮与Morita–Baylis–Hillman（MBH）碳酸盐的[3 + 2]环化反应顺利进行，从而以中等收率产生了相应的季碳中心的螺环式环戊烯在温和条件下具有较高的非对映选择性和对映选择性。在先前的文献基础上，也对合理的反应进行了讨论。
• Phosphine-Catalyzed [4 + 3] Annulation for the Synthesis of Highly Functionalized Bicyclo[3.2.2]nonadienes
  作者：Suqing Zheng、Xiyan Lu

  DOI：10.1021/ol901618h

  日期：2009.9.3

  A phosphine-catalyzed [4 + 3] annulation of modified allylic carbonates with methyl coumalate was developed. This strategy offered a powerful method for the construction of bicyclo[3.2.2]nonadiene skeleton with high stereoselectivity.

  开发了膦用香豆酸甲酯催化的[4 + 3]改性烯丙基碳酸酯的环化反应。该策略为构建具有高立体选择性的双环[3.2.2]壬二烯骨架提供了有力的方法。
• Phosphine-catalyzed [3+3] annulation reaction of modified tert-butyl allylic carbonates and substituted alkylidenemalononitriles
  作者：Suqing Zheng、Xiyan Lu

  DOI：10.1016/j.tetlet.2009.05.085

  日期：2009.8

  A phosphine-catalyzed [3+3] annulation reaction of modified tert-butyl allylic carbonates with various alkylidenemalononitriles to form cyclohexenes was developed. The use of protic solvent is crucial in this reaction. When non-polar solvent, toluene or xylene, was used, only non-cyclized product was obtained. (C) 2009 Elsevier Ltd. All rights reserved.