3-amino-2,4-dicyano-5-(2-thienyl)biphenyl | 77198-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-2,4-dicyano-5-(2-thienyl)biphenyl
• 英文别名: 3-amino-5-(thiophen-2-yl)-[1,1'-biphenyl]-2,4-dicarbonitrile；2-Amino-4-phenyl-6-thiophen-2-ylbenzene-1,3-dicarbonitrile
• CAS: 77198-56-2
• 化学式: C₁₈H₁₁N₃S
• 分子量: 301.371
• InChiKey: NSOVAGFDTXJIAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl (E)-2-cyano-3-(2-thienyl)-2-propenoate 、 2-(1-苯基亚乙基)丙二腈 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 3-amino-2,4-dicyano-5-(2-thienyl)biphenyl
  参考文献：
  名称：

  Elagamey, Abdel Ghani A.; Sofan, Mamdouh A.; Kandeel, Zaghloul E., Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 6, p. 1561 - 1565

  摘要：

  DOI：

文献信息

• CoFe₂O₄@SiO₂‐PA‐CC‐guanidine nanoparticles: A novel, efficient, and recyclable catalyst for the synthesis of 3,5‐disubstituted‐2,6‐dicyanoaniline derivatives
  作者：Hedieh Rostami、Lotfi Shiri

  DOI：10.1002/aoc.5599

  日期：2020.5

  synthesis of 3,5‐disubstituted‐2,6‐dicyanoaniline derivatives by CoFe2O4@SiO2‐PA‐CC‐guanidine magnetic nanoparticles (MNPs) was reported. 3,5‐Disubstituted‐2,6‐dicyanoaniline derivatives were synthesized from malononitrile, aldehydes, and β‐nitrostyrene derivatives in good yields. MNPs used for the synthesis of aniline derivatives were easy to recover and reuse. The CoFe2O4@SiO2‐PA‐CC‐guanidine MNPs were

  报道了一种通过CoFe 2 O 4 @SiO 2 -PA-CC-胍磁性纳米粒子（MNPs）合成3,5-二取代-2,6-二氰基苯胺衍生物的有效新方法。由丙二腈，醛和β-硝基苯乙烯衍生物合成3,5-二取代-2,6-二氰基苯胺衍生物，收率很高。用于合成苯胺衍生物的MNP易于回收和再利用。CoFe 2 O 4 @SiO 2 -PA-CC-胍MNPs的特征在于傅立叶变换红外光谱，扫描电子显微镜，能量色散X射线光谱，X射线衍射，热重分析和振动样品磁力分析技术。
• Nitriles in Organic Synthesis. The Chemical Behavior of [1-(2-Furyl)-ethylidene]- and [1-(2-Thienyl)ethylidene]malononitriles
  作者：Mohamed Abdallah El-Maghraby、Kamal Usef Sadek、Maghraby Ali Selim、Mohamed Hilmy Elnagdi

  DOI：10.1246/bcsj.61.1375

  日期：1988.4

  The chemical behavior of [1-(2-furyl)ethylidene]- and [1-(2-thienyl)ethylidene]malononitriles 1a and b toward electrophilic reagents, active methylene reagents and (arylmethylene)malononitriles is described.

  描述了[1-(2-呋喃基)亚乙基]-和[1-(2-噻吩基)亚乙基]丙二腈1a和b对亲电子试剂、活性亚甲基试剂和(芳基亚甲基)丙二腈的化学行为。
• Sharanin, Yu. A.; Baskakov, Yu. A.; Abramenko, Yu. T., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1870 - 1879
  作者：Sharanin, Yu. A.、Baskakov, Yu. A.、Abramenko, Yu. T.、Putsykin, Yu. G.、Vasil'ev, A. F.、Nazarova, E.B.

  DOI：——

  日期：——
• Synthesis of nicotinonitrile derivatives as a new class of NLO materials
  作者：V Raghukumar、D Thirumalai、V.T Ramakrishnan、V Karunakara、P Ramamurthy

  DOI：10.1016/s0040-4020(03)00507-6

  日期：2003.5

  4,6-Diaryl-2-(pyrrolidin-1-yl)-nicotinonitriles 2a-k and 3-amino-2,4-dicyano-5-aryl-biphenyls 3a-c were synthesized from 1,3-diaryl-prop-2-en-1-ones 1a-k and malononitrile by a convenient one-pot method. Likewise, the reaction of aromatic aldehydes with malononitrile afforded 6-amino-4-aryl-2-(pyrrolidin-1-yl)-pyridine-3,5-dicarbonitriles 6a-f. The reaction of mesityl oxide with malononitrile gave 5-amino-7-(pyrrolidin-1-yl)-2,4,4-trimethyl-1,4-dihydro-1,6-naphthyridine-8-carbonitrile 8. The NLO studies of the pyridinedinitrile derivatives 6a, b, f showed a high value while that of nicotinonitrile 2b was weak. (C) 2003 Elsevier Science Ltd. All rights reserved.
• SHARANIN YU. A.; BASKAKOV YU. A.; ABRAMENKO YU. T.; PUTSYKIN YU. G.; VASI+, ZH. ORGAN. XIMII, 1980, 16, HO 10, 2192-2204
  作者：SHARANIN YU. A.、 BASKAKOV YU. A.、 ABRAMENKO YU. T.、 PUTSYKIN YU. G.、 VASI+

  DOI：——

  日期：——