N-tert-Butyl-3,6-dihydropyridine-1(2H)-carboxamide | 87943-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-tert-Butyl-3,6-dihydropyridine-1(2H)-carboxamide
• 英文别名: N-tert-butyl-3,6-dihydro-2H-pyridine-1-carboxamide
• CAS: 87943-74-6
• 化学式: C₁₀H₁₈N₂O
• 分子量: 182.26
• InChiKey: OEKCIYSZSCNPTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS
  申请人：OSI Pharmaceuticals, Inc.

  公开号：EP1797054A2

  公开（公告）日：2007-06-20
• [EN] ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS<br/>[FR] COMPOSES A BASE DE PYRROLOPYRIMIDINE A SUBSTITUTION ARYLAMINE INHIBITEURS DE KINASES MULTIPLES
  申请人：OSI PHARM INC

  公开号：WO2006017443A2

  公开（公告）日：2006-02-16

  Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.