1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid | 856859-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid
• 英文别名: 4-(3-Aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid
• CAS: 856859-29-5
• 化学式: C₁₅H₁₆N₂O₄
• 分子量: 288.303
• InChiKey: BXKJGRAEVKIDAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dimethyl ester,10b 、 1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid 、 氯甲酸甲酯 生成 1,4-Dihydro-4-[3-[(methoxycarbonyl)amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Dihydropyridine NPY antagonists: piperidine derivatives
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0747357A2

  公开（公告）日：1996-12-11

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

  一系列 NPY 非肽能拮抗剂已经合成，它们由式 I 的 4-苯基-1,4-二氢吡啶的哌啶和四氢吡啶衍生物组成。 作为 NPY 诱导的摄食行为的拮抗剂，这些化合物有望成为促进减肥和治疗饮食失调的有效厌食剂。
• Dihydropyridine NPY antagonists
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0747378A1

  公开（公告）日：1996-12-11

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and trating eating disorders.

  一系列非肽能性 NPY 拮抗剂已经合成，它们由式（I）的 4-苯基-1,4-二氢吡啶的氮杂环衍生物组成。 作为 NPY 诱导的摄食行为的拮抗剂，这些化合物有望成为促进减肥和治疗饮食失调的有效厌食剂。
• Dihydropyridine NPY antagonists: piperazine derivatives
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0747356A1

  公开（公告）日：1996-12-11

  A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

  一系列 NPY 非肽能拮抗剂已经合成，它们由式（I）的 4-苯基-1,4-二氢吡啶的哌嗪和均哌嗪衍生物组成。 作为 NPY 诱导的摄食行为的拮抗剂，这些化合物有望成为促进减肥和治疗饮食失调的有效镇静剂。
• US5554621A
  申请人：——

  公开号：US5554621A

  公开（公告）日：1996-09-10
• US5635503A
  申请人：——

  公开号：US5635503A

  公开（公告）日：1997-06-03