N-diazo-4-[[(4-fluoro-3-nitrophenyl)methyl-(2-phenylsulfanylethyl)amino]methyl]benzenesulfonamide | 1182329-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-diazo-4-[[(4-fluoro-3-nitrophenyl)methyl-(2-phenylsulfanylethyl)amino]methyl]benzenesulfonamide
• CAS: 1182329-79-8
• 化学式: C₂₂H₂₀FN₅O₄S₂
• 分子量: 501.562
• InChiKey: PHMSJPAYONCCKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-氟-3-硝基苄醇 在 N,N-二异丙基乙胺 作用下， 反应 3.0h， 生成 N-diazo-4-[[(4-fluoro-3-nitrophenyl)methyl-(2-phenylsulfanylethyl)amino]methyl]benzenesulfonamide
  参考文献：
  名称：

  [EN] ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME
  [FR] ACYLSULFONAMIDES ET PROCÉDÉS POUR PRODUIRE CEUX-CI

  摘要：

  公开号：

  WO2012021486A3

文献信息

• Acylsulfonamides and Processes for Producing the Same
  申请人：Manetsch Roman

  公开号：US20110130568A1

  公开（公告）日：2011-06-02

  The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
• ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME
  申请人：Manetsch Roman

  公开号：US20130203709A1

  公开（公告）日：2013-08-08

  The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
• US8524947B2
  申请人：——

  公开号：US8524947B2

  公开（公告）日：2013-09-03
• [EN] ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME<br/>[FR] ACYLSULFONAMIDES ET PROCÉDÉS DE PRODUCTION DE CES DERNIERS
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2009105751A1

  公开（公告）日：2009-08-27

  The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
• [EN] ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME<br/>[FR] ACYLSULFONAMIDES ET PROCÉDÉS POUR PRODUIRE CEUX-CI
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2012021486A3

  公开（公告）日：2012-05-31