2-乙氧基-1,3-苯并恶唑 | 81759-34-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 中文名称: 2-乙氧基-1,3-苯并恶唑
• 英文名称: 2-Ethoxy-1,3-benzoxazol
• 英文别名: 2-ethoxybenzoxazole；2-ethoxy-benzooxazole；2-ethoxy-benzoxazole；2-Aethoxy-benzoxazol；2-Ethoxy-1,3-benzoxazole
• CAS: 81759-34-4
• 化学式: C₉H₉NO₂
• 分子量: 163.176
• InChiKey: GYBFWKLMUUAXGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  35.26
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-乙氧基-1,3-苯并恶唑 在 盐酸 作用下， 生成 2-苯并唑啉酮
  参考文献：
  名称：

  Sandmeyer, Chemische Berichte, 1886, vol. 19, p. 2654

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯苯并恶唑 在 sodium hydroxide 作用下， 生成 2-乙氧基-1,3-苯并恶唑
  参考文献：
  名称：

  McCoy, American Chemical Journal, 1899, vol. 21, p. 123

  摘要：

  DOI：

文献信息

• A new method for the preparation of 2-alkoxybenzoxazoles.
  作者：MASATOSHI YAMATO、YASUO TAKEUCHI、KYOKO HATTORI、KUNIKO HASHIGAKI

  DOI：10.1248/cpb.31.3946

  日期：——

  A one-pot synthesis of 2-alkoxybenzoxazole (I) from benzoxazoline-2-thione (II) was achieved. Treatment of benzoxazoline-2-thione with methyl iodide followed by an alcohol at room temperature in the presence of sodium hydride gave I. The reaction involves the intermediate of 2-(methylthio) benzoxazole (IIIa), followed by substitution of the methylthio group by an alkoxide anion. The general applicability of this method is discussed.

  一种从苯并噁唑-2-硫酮（II）合成2-烷氧基苯并噁唑（I）的单锅合成法得以实现。将在室温下用碘甲烷处理苯并噁唑-2-硫酮，然后在氢化钠存在下加入醇，可以得到I。该反应涉及中间体2-(甲硫基)苯并噁唑（IIIa），随后通过烷氧负离子取代甲硫基。讨论了该方法的普遍适用性。
• Cs ₂ CO ₃ ‐Promoted C−O Coupling Protocol Enables Solventless (Hetero)aryl Ether Synthesis under Air Atmosphere
  作者：Bowen Jiang、Cheng Chen、Guang‐Gao Fan、Wei Sang、Hua Cheng、Rui Zhang、Ye Yuan、Qi‐Zhong Li、Francis Verpoort

  DOI：10.1002/asia.202101370

  日期：2022.3.14

  A Cs2CO3-promoted C−O coupling protocol was developed to enable the facile synthesis of (hetero)aryl ethers under transition-metal-free and solvent-free conditions. Moreover, this protocol was scalable to gram scales and applicable to the synthesis of bioactive molecules, which reflected its potential application prospect. Finally, DFT calculations and a few experiments were carried out to propose

  开发了一种 Cs 2 CO 3促进的 C-O 偶联方案，以实现在无过渡金属和无溶剂条件下轻松合成（杂）芳基醚。此外，该协议可扩展到克级，适用于生物活性分子的合成，体现了其潜在的应用前景。最后，进行了 DFT 计算和一些实验，以提出可能的途径。
• AN EFFICIENT METHOD FOR THE SYNTHESIS OF MIXED DIESTERS OF PHOSPHORIC ACID
  作者：Teruaki Mukaiyama、Naoya Morito、Yutaka Watanabe

  DOI：10.1246/cl.1979.895

  日期：1979.8.5

  hydrogen phosphate, and subsequent removal of one of two p-nitrophenoxy groups in the resulting alkyl bis(p-nitrophenyl) phosphate gave alkyl p-nitrophenyl phosphates. These were then converted to mixed dialkyl hydrogen phosphates in good overall yields by repetition of the above two-step procedure. The stepwise removal of two p-nitrophenoxy groups was successfully accomplished by the use of tetrabutylammonium

  2-烷氧基苯并恶唑与双(对硝基苯基)磷酸氢盐反应，随后除去所得双(对硝基苯基)磷酸烷基酯中的两个对硝基苯氧基之一，得到烷基对硝基苯基磷酸酯。然后通过重复上述两步程序将它们以良好的总产率转化为混合的磷酸氢二烷基酯。通过在非常温和的条件下使用四丁基乙酸铵成功地逐步去除两个对硝基苯氧基。
• Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
  申请人：The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada

  公开号：US10945996B2

  公开（公告）日：2021-03-16

  Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本文提供了用于减少、预防和/或抑制C. perfringens孢子萌发的材料和方法，包括抑制C. perfringens萌发以减少动物坏死性肠炎（NE，也称为坏死性肠炎）的方法。本摘要旨在作为特定技术领域的扫描工具，供检索之用，并非对本发明的限制。
• The Reactions of Thiols with Some Alkyl and Aryl Heterocyclic Ethers
  作者：Gabriello. Illuminati、Henry. Gilman

  DOI：10.1021/ja01178a021

  日期：1949.10