4-N,6-N-bis(6-chloropyrimidin-4-yl)-4-N,6-N-bis(prop-2-enyl)pyrimidine-4,6-diamine | 1206706-13-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-N,6-N-bis(6-chloropyrimidin-4-yl)-4-N,6-N-bis(prop-2-enyl)pyrimidine-4,6-diamine
• CAS: 1206706-13-9
• 化学式: C₁₈H₁₆Cl₂N₈
• 分子量: 415.285
• InChiKey: JTZMTNUWGRBVIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  83.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-N,6-N-bis(6-chloropyrimidin-4-yl)-4-N,6-N-bis(prop-2-enyl)pyrimidine-4,6-diamine 、 N4,N6-二甲基嘧啶-4,6-二胺 在 sodium hydride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 8.0h， 以56%的产率得到2,8-Dimethyl-14,20-bis(prop-2-enyl)-2,4,6,8,10,12,14,16,18,20,22,24-dodecazapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaene
  参考文献：
  名称：

  Synthesis and Highly Selective Bromination of Azacalix[4]pyrimidine Macrocycles

  摘要：

  A number of N-substituted azacalix[4]pyrimidines were synthesized by two methods. While straightforward condensation reaction between 4,6-dichloropyrimidine and 4,6-bis(alkylamino)-pyrimidines gave identically N-substituted azacalix[4]pyrimidines in low yields, a general and moderate-to-high yielding 1 + 3 macrocyclic fragment coupling reaction afforded azacalix[4]pyrimidines that contained either the same or different N-substituents. Upon treatment with N-bromosuccinimide (NBS) Under controlled conditions, methylazacalix[4]pyrimidine was selectively brominated at lower rim to produce mono-, di-, and tribrominated azacalix[4]pyrimidines in good yields. While azacalix[4]pyrimidine derivatives adopted 1,3-alternate conformation in the solid state, the synthesized macrocycles were fluxional In solution, and the interconversion of various conformational structures was rapid relative to the NMR time scale.

  DOI：

  10.1021/jo902245q
• 作为产物：
  描述：

  N⁴,N⁶-diallyl-pyrimidine-4,6-diyldiamine 、 4,6-二氯嘧啶 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以75%的产率得到4-N,6-N-bis(6-chloropyrimidin-4-yl)-4-N,6-N-bis(prop-2-enyl)pyrimidine-4,6-diamine
  参考文献：
  名称：

  Synthesis and Highly Selective Bromination of Azacalix[4]pyrimidine Macrocycles

  摘要：

  A number of N-substituted azacalix[4]pyrimidines were synthesized by two methods. While straightforward condensation reaction between 4,6-dichloropyrimidine and 4,6-bis(alkylamino)-pyrimidines gave identically N-substituted azacalix[4]pyrimidines in low yields, a general and moderate-to-high yielding 1 + 3 macrocyclic fragment coupling reaction afforded azacalix[4]pyrimidines that contained either the same or different N-substituents. Upon treatment with N-bromosuccinimide (NBS) Under controlled conditions, methylazacalix[4]pyrimidine was selectively brominated at lower rim to produce mono-, di-, and tribrominated azacalix[4]pyrimidines in good yields. While azacalix[4]pyrimidine derivatives adopted 1,3-alternate conformation in the solid state, the synthesized macrocycles were fluxional In solution, and the interconversion of various conformational structures was rapid relative to the NMR time scale.

  DOI：

  10.1021/jo902245q

文献信息

• Synthesis and Highly Selective Bromination of Azacalix[4]pyrimidine Macrocycles
  作者：Li-Xia Wang、De-Xian Wang、Zhi-Tang Huang、Mei-Xiang Wang

  DOI：10.1021/jo902245q

  日期：2010.2.5

  A number of N-substituted azacalix[4]pyrimidines were synthesized by two methods. While straightforward condensation reaction between 4,6-dichloropyrimidine and 4,6-bis(alkylamino)-pyrimidines gave identically N-substituted azacalix[4]pyrimidines in low yields, a general and moderate-to-high yielding 1 + 3 macrocyclic fragment coupling reaction afforded azacalix[4]pyrimidines that contained either the same or different N-substituents. Upon treatment with N-bromosuccinimide (NBS) Under controlled conditions, methylazacalix[4]pyrimidine was selectively brominated at lower rim to produce mono-, di-, and tribrominated azacalix[4]pyrimidines in good yields. While azacalix[4]pyrimidine derivatives adopted 1,3-alternate conformation in the solid state, the synthesized macrocycles were fluxional In solution, and the interconversion of various conformational structures was rapid relative to the NMR time scale.