Methyl 3,5-tetradecyloxybenzene-1,3-dicarboxylate | 62443-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3,5-tetradecyloxybenzene-1,3-dicarboxylate
• 英文别名: dimethyl 5-tetradecyloxyisophthalate；Dimethyl-5-tetradecyloxyisophthalate；dimethyl 5-tetradecoxybenzene-1,3-dicarboxylate
• CAS: 62443-19-0
• 化学式: C₂₄H₃₈O₅
• 分子量: 406.563
• InChiKey: WQVTVALILPRSMI-UHFFFAOYSA-N

物化性质

• 熔点：
  58-62 °C(Solv: methanol (67-56-1))
• 沸点：
  498.8±25.0 °C(Predicted)
• 密度：
  1.006±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  29
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 3,5-tetradecyloxybenzene-1,3-dicarboxylate 在 lithium aluminium tetrahydride 作用下， 生成 1-tetradecyloxy-3,5-bis(hydroxymethyl)benzene
  参考文献：
  名称：

  Molecular design of thermotropic liquid crystalline polyhydroxy amphiphiles exhibiting columnar and cubic mesophases of the normal type

  摘要：

  相序Colh1-CubV1-SA-Colh2-CubI2是洗涤剂溶剂系统理论相图中的重要部分，首次在不含任何溶剂的两种热致性两亲液晶的二元混合物中实现。

  DOI：

  10.1039/a808271e
• 作为产物：
  描述：

  溴代十四烷 、 5-羟基间苯二甲酸二甲酯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以60.2%的产率得到Methyl 3,5-tetradecyloxybenzene-1,3-dicarboxylate
  参考文献：
  名称：

  [EN] ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE
  [FR] AMPHIPHILES ANTIMICROBIENS ET PROCÉDÉS POUR LEUR UTILISATION

  摘要：

  公开号：

  WO2012054695A8

文献信息

• 5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids
  作者：Roger A. Parker、Takashi Kariya、J. Martin Grisar、Vladimir Petrow

  DOI：10.1021/jm00216a009

  日期：1977.6

  5-(Tetradecyloxy)-2-furancarboxylic acid (91, RMI 14514) was found to lower blood lipids and to inhibit fatty acid synthesis with minimal effects on liver weight and liver fat content. This fatty acid-like compound represents a new class of hypolipidemic agent; it is effective in rats and monkeys. The compound resulted from discovery of hypolipidemic activity in certain beta-keto esters, postulation

  发现5-（四氢癸氧基）-2-呋喃羧酸（91，RMI 14514）可以降低血脂并抑制脂肪酸合成，对肝脏重量和肝脏脂肪含量的影响最小。这种类似脂肪酸的化合物代表了一类新的降血脂药。对大鼠和猴子有效。该化合物的产生是由于发现了某些β-酮酸酯的降血脂活性，假定和确认了相应的苯甲酸作为活性代谢物以及系统地研究了结构-活性关系。
• ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE
  申请人：Minbiole Kevin P.

  公开号：US20140148487A1

  公开（公告）日：2014-05-29

  The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.

  本发明涉及用于抗微生物应用的组合物。这些组合物包括两性化合物。
• Antimicrobial amphiphiles and methods for their use
  申请人：Minbiole Kevin P.

  公开号：US08980925B2

  公开（公告）日：2015-03-17

  The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.

  本发明涉及用于抗微生物应用的组合物。这些组合物包括两性化合物。
• Bicephalic amphiphile architecture affects antibacterial activity
  作者：Jade E. LaDow、David C. Warnock、Kristina M. Hamill、Kaitlin L. Simmons、Robert W. Davis、Christian R. Schwantes、Devon C. Flaherty、Jon A.L. Willcox、Kelsey Wilson-Henjum、Kevin L. Caran、Kevin P.C. Minbiole、Kyle Seifert

  DOI：10.1016/j.ejmech.2011.06.026

  日期：2011.9

  A series of cationic amphiphiles, each with an aromatic core, was prepared and investigated for antimicrobial properties. The synthesized amphiphiles in this study are bicephalic (double-headed) in that they each possess two trimethylammonium head groups and a single linear alkoxy tail. Minimum inhibitory and minimum bactericidal concentrations of these amphiphiles were in the low micromolar range. Antimicrobial activities are highly sensitive to the chain length of the hydrophobic region, and modestly reliant on the relative positioning of the head groups on the aromatic core. These trends were more pronounced in time kill assays, wherein longer chain compounds required significantly shorter times to completely kill bacteria. Microscopy suggested that the mode of cell death was lysis. Strong inhibition was observed with both biscationic compounds and monocationic comparisons against Gram-positive bacteria: only biscationic amphiphiles maintained good activity versus the Gram-negative bacteria tested. These observations provide direction for future antimicrobial structural investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.
• US8980925B2
  申请人：——

  公开号：US8980925B2

  公开（公告）日：2015-03-17