1-tetradecyl-1-azonia-4-azabicyclo<2.2.2>octane bromide | 475661-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-tetradecyl-1-azonia-4-azabicyclo<2.2.2>octane bromide
• 英文别名: 1-Tetradecyl-4-aza-1-azoniabicyclo[2.2.2]octane
• CAS: 475661-84-8
• 化学式: C₂₀H₄₁N₂
• 分子量: 309.559
• InChiKey: PKCAKVSESSBYAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-tetradecyl-1-azonia-4-azabicyclo<2.2.2>octane bromide 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 30.0h， 生成 1-tetradecyl-4-γ-propyl-1,4-diazoniabicyclo<2.2.2>octane dibromide
  参考文献：
  名称：

  Artificial ribonucleases: synthesis and RNA cleaving properties of cationic conjugates bearing imidazole residues

  摘要：

  Small mimics of the ribonuclease active centre were synthesized by conjugating imidazole residues to a dicationic compound. These compounds were shown to cleave tRNA under physiological conditions. The compounds provide new probes for the investigation of RNA structure in solution and potential catalytic RNA cleaving groups for antisense oligonucleotide derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)01048-5
• 作为产物：
  描述：

  三乙烯二胺 、 溴代十四烷 以 乙醚 、 丙酮 为溶剂， 反应 6.0h， 以89%的产率得到1-tetradecyl-1-azonia-4-azabicyclo<2.2.2>octane bromide
  参考文献：
  名称：

  Artificial ribonucleases: synthesis and RNA cleaving properties of cationic conjugates bearing imidazole residues

  摘要：

  Small mimics of the ribonuclease active centre were synthesized by conjugating imidazole residues to a dicationic compound. These compounds were shown to cleave tRNA under physiological conditions. The compounds provide new probes for the investigation of RNA structure in solution and potential catalytic RNA cleaving groups for antisense oligonucleotide derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)01048-5

文献信息

• US7241453B2
  申请人：——

  公开号：US7241453B2

  公开（公告）日：2007-07-10
• US7285286B2
  申请人：——

  公开号：US7285286B2

  公开（公告）日：2007-10-23
• Artificial ribonucleases: synthesis and RNA cleaving properties of cationic conjugates bearing imidazole residues
  作者：Dmitrii A. Konevetz、Irene E. Beck、Natalia G. Beloglazova、Ilya V. Sulimenkov、Vladimir N. Sil'nikov、Marina A. Zenkova、Gennadiy V. Shishkin、Valentin V. Vlassov

  DOI：10.1016/s0040-4020(98)01048-5

  日期：1999.1

  Small mimics of the ribonuclease active centre were synthesized by conjugating imidazole residues to a dicationic compound. These compounds were shown to cleave tRNA under physiological conditions. The compounds provide new probes for the investigation of RNA structure in solution and potential catalytic RNA cleaving groups for antisense oligonucleotide derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.