2-(benzoylamino-methyl)-benzo[d][1,3]oxazin-4-one | 58155-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2-(benzoylamino-methyl)-benzo[d][1,3]oxazin-4-one
• 英文别名: N-(4-oxo-4H-benz[d][1,3]oxazin-2-ylmethyl)-benzamide；N-(4-Oxo-4H-benz[d][1,3]oxazin-2-ylmethyl)-benzamid；N-[(4-oxo-3,1-benzoxazin-2-yl)methyl]benzamide
• CAS: 58155-81-0
• 化学式: C₁₆H₁₂N₂O₃
• 分子量: 280.283
• InChiKey: ZNUFXKOPEZOKAT-UHFFFAOYSA-N

物化性质

• 熔点：
  205-207 °C
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(benzoylamino-methyl)-benzo[d][1,3]oxazin-4-one 在 吡啶 、 一水合肼 作用下， 反应 6.0h， 生成
  参考文献：
  名称：

  Synthesis and biological properties of 4-(3H)-quinazolone derivatives

  摘要：

  A new quinazolone series has been designed, and synthesized by the anthranilic acid and different acid derivatives. Their structures have been elucidated on the basis of elemental analyses and spectral studies (IR, H-1 NMR, FT-IR and FAB-MS). A preliminary radiolabelling study with technetium has shown a very good future prospect for further evaluation in vivo. The biological activities (antifungal, antibacterial as well as anticancerous) of the evaluated compounds are discussed in this article. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.01.002
• 作为产物：
  描述：

  hippuryl chloride 、 邻氨基苯甲酸 在 吡啶 作用下， 生成 2-(benzoylamino-methyl)-benzo[d][1,3]oxazin-4-one
  参考文献：
  名称：

  Tiwari; Pandey, Journal of the Indian Chemical Society, 1975, vol. 52, # 8, p. 736 - 737

  摘要：

  DOI：

文献信息

• Ghosh, Journal of the Indian Chemical Society, 1937, vol. 14, p. 113
  作者：Ghosh

  DOI：——

  日期：——
• Tiwari; Pandey, Journal of the Indian Chemical Society, 1975, vol. 52, # 8, p. 736 - 737
  作者：Tiwari、Pandey

  DOI：——

  日期：——
• TIWARI S. S.; PANDEY V. K., J. INDIAN CHEM. SOC. <JICS-AH>, 1975, 52, NO 8, 736-737
  作者：TIWARI S. S.、 PANDEY V. K.

  DOI：——

  日期：——
• Ghosh, Journal of the Indian Chemical Society, 1937, vol. 14, p. 411
  作者：Ghosh

  DOI：——

  日期：——
• Synthesis and biological properties of 4-(3H)-quinazolone derivatives
  作者：Anjani K. Tiwari、Vinay Kumar Singh、Aruna Bajpai、Gauri Shukla、Sweta Singh、Anil K. Mishra

  DOI：10.1016/j.ejmech.2007.01.002

  日期：2007.9

  A new quinazolone series has been designed, and synthesized by the anthranilic acid and different acid derivatives. Their structures have been elucidated on the basis of elemental analyses and spectral studies (IR, H-1 NMR, FT-IR and FAB-MS). A preliminary radiolabelling study with technetium has shown a very good future prospect for further evaluation in vivo. The biological activities (antifungal, antibacterial as well as anticancerous) of the evaluated compounds are discussed in this article. (c) 2007 Elsevier Masson SAS. All rights reserved.