(2-Carboxy-6-bromophenyl)propanedioic Acid Dimethyl Ester | 129689-09-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Carboxy-6-bromophenyl)propanedioic Acid Dimethyl Ester
• 英文别名: 3-Bromo-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoic acid
• CAS: 129689-09-4
• 化学式: C₁₂H₁₁BrO₆
• 分子量: 331.12
• InChiKey: RHKJRNRCIDDWRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0365324A1

  公开（公告）日：1990-04-25

  This invention relates to spiro-isoquinoline-­pyrrolidine tetrones and pharmaceutically acceptable salts thereof having formula I: and analogues thereof wherein the fused benzene ring is replaced by a fused thiophene, pyridine or furan ring, wherein R¹ , R² and R³ are independently hydrogen or defined substituents and M, W, X, Y and Z have defined meanings. Processes for preparing the compounds and pharmaceutical compositions are also provided. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.

  本发明涉及具有式 I 的螺-异喹啉-吡咯烷四元化合物及其药学上可接受的盐类： 及其类似物，其中融合的苯环被融合的噻吩环、吡啶环或呋喃环取代，其中R¹、R²和R³独立地为氢或定义的取代基，M、W、X、Y和Z具有定义的含义。此外，还提供了制备这些化合物和药物组合物的工艺。 这些化合物具有药物特性，使其有利于预防或治疗糖尿病相关并发症。
• ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0555327B1

  公开（公告）日：1999-01-13
• 1'-AMINOSPIRO ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0553263A1

  公开（公告）日：1993-08-04
• 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0553263B1

  公开（公告）日：1998-08-05
• ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0555327A1

  公开（公告）日：1993-08-18