1,4:3,6‐dianhydro‐alpha‐d‐glucopyranose | 4451-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: 1,4:3,6‐dianhydro‐alpha‐d‐glucopyranose
• 英文别名: 1,4; 3,6-dianhydro-α-D-glucopyranose；1,4:3,6-dianhydro-α-D-glucopyranose；1,4:3,6-dianhydro-α-D-glycopyranose；1,4:3,6-dianhydro-β-D-glucopyranose；1,4:3,6-dianhydro-alpha-D-glucopyranose；1,4,3,6-dianhydroglucopyranose；Xotjghcmzolipx-qzabapfnsa-；(1R,3R,6R,7R,9R)-2,5,8-trioxatricyclo[4.2.1.03,7]nonan-9-ol
• CAS: 4451-31-4；4451-30-3
• 化学式: C₆H₈O₄
• 分子量: 144.127
• InChiKey: XOTJGHCMZOLIPX-QZABAPFNSA-N

物化性质

• 熔点：
  122-123℃
• 沸点：
  317.3±37.0 °C(Predicted)
• 密度：
  1.569±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

制备方法与用途

生物活性化合物1,4:3,6-Dianhydro-α-D-glucopyranose 可从B. noctiflora 的叶子中提取。

反应信息

• 作为产物：
  描述：

  isosorbide-2,5-dinitrate 400.0~450.0 ℃ 、6.67 Pa 条件下， 生成 1,4:3,6‐dianhydro‐alpha‐d‐glucopyranose 、 1,4,3,6-dianhydrofructose 、 1,4,3,6-dianhydromannopyranose
  参考文献：
  名称：

  制备型闪蒸真空热解。异甘露糖和硝酸异山梨酯的均相裂解为1,4,3,6-二脱水己糖

  摘要：

  1,4,3,6-dianhydromannopyranose（3）可以通过快速真空热解硝酸异甘露酯（1）来制备，而其差向异构体异山梨醇二硝酸酯（2）则可以得到（3）和1,4,3,6的混合物。-双脱水果糖（5），反映了在顺式-融合的呋喃呋喃自由基中间基团中可能发生的重排数量受限，在一种情况下具有构型反转的情况。

  DOI：

  10.1039/c39870001397

文献信息

• Furneaux, Richard H.; Mason, Jennifer M.; Miller, Ian J., Journal of the Chemical Society. Perkin transactions I, 1988, p. 49 - 52
  作者：Furneaux, Richard H.、Mason, Jennifer M.、Miller, Ian J.

  DOI：——

  日期：——
• MICROWAVE TORREFACTION OF BIOMASS
  申请人：University of York

  公开号：EP2318487B1

  公开（公告）日：2019-05-01
• FERMENTED BEVERAGES FROM CANNABIS AND METHODS FOR PRODUCTION THEREOF
  申请人：Honest Inc.

  公开号：US20210147770A1

  公开（公告）日：2021-05-20

  A fermented beverage is described together with a method for its production from one or more component of a Cannabis plant. The beverage comprises carbohydrates derived from hydrolysis of cellulose and/or hemicellulose from Cannabis , as a fermentation substrate. The beverage may contain alcohol or may be non-alcoholic. Active phytocannabinoid compounds may be present, preferably in the non-alcoholic beverages. The method includes the steps of (a) obtaining a cellulose-rich pulp from the one or more components of the Cannabis plant, from which lignin and/or hemicellulose has been released (through any number of multiple prehydrolysis steps); (b) degrading the cellulose-rich pulp into carbohydrates (saccharification step) with enzymatic hydrolysis by one or more cellulose-degrading and/or hemicellulose-degrading enzymes, and/or with acid hydrolysis to form carbohydrates; (c) preparing a wort from the carbohydrates with (or if desired without) sufficient yeast nutritional requirements and flavoring from portions of the Cannabis plant; and (d) fermenting the wort to form the fermented beverage. (e) Optionally performing steps to finish the beer including but not limited to aging, alcohol removal, formulation and flavoring by addition of phytocannabinoids and/or terpenes, xylooligimers, and/or Cannabis extracts and/or Cannabis oils with or without accelerants (to accelerate the onset of the bioactive effect) and/or deccelerants (to shorten the duration of the bioactive effect) as desired. The optional removal of alcohol may be conducted by reverse osmosis or other process. Phytocannabinoids or flavorings may be introduced as desired.
• Preparative flash vacuum thermolysis. Homolytic cleavage of isomannide and isosorbide dinitrate to 1,4,3,6-dianhydrohexoses
  作者：Jan G. Batelaan、Anton J. M. Weber、Ulfert E. Wiersum

  DOI：10.1039/c39870001397

  日期：——

  1,4,3,6-dianhydromannopyranose (3) can be conveniently prepared by flash vacuum thermolysis of isomannide dinitrate (1), while its epimer isosorbide dinitrate (2) yields a mixture of (3) and 1,4,3,6-dianhydrofructose (5), reflecting the restricted number of rearrangements, in one case with inversion of configuration, possible in the intermediate cis-fused furofuran radicals.

  1,4,3,6-dianhydromannopyranose（3）可以通过快速真空热解硝酸异甘露酯（1）来制备，而其差向异构体异山梨醇二硝酸酯（2）则可以得到（3）和1,4,3,6的混合物。-双脱水果糖（5），反映了在顺式-融合的呋喃呋喃自由基中间基团中可能发生的重排数量受限，在一种情况下具有构型反转的情况。